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1.发明授权公开(公告)号：US08137700B2
公开(公告)日：2012-03-20
申请号：US12299506
申请日：2007-05-04
CPC分类号： A61K31/787 , A61K9/1641 , A61K47/34
摘要： Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.
摘要翻译： 描述了由能够将生物活性物质递送至用作疫苗或其它治疗剂的细胞的材料组成的新型主链酸可降解聚合物主链和药物递送系统。 使用含有酸可降解键的单体在温和的酸性条件下可裂解来合成聚合物。 所得聚合物的主链在低pH下容易降解成许多小分子，但在生理pH下保持相对稳定和完整。 新材料具有在细胞的内体或溶酶体区室内通常发现的条件下能够通过酸水解降解的共同特征，从而释放其在细胞内的有效载荷。 这些材料也可以用于将治疗剂递送到肿瘤和其它炎症部位的酸性区域。
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2.发明申请公开(公告)号：US20090220615A1
公开(公告)日：2009-09-03
申请号：US12299506
申请日：2007-05-04
CPC分类号： A61K31/787 , A61K9/1641 , A61K47/34
摘要： Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.
摘要翻译： 描述了由能够将生物活性物质递送至用作疫苗或其它治疗剂的细胞的材料组成的新型主链酸可降解聚合物主链和药物递送系统。 使用含有酸可降解键的单体在温和的酸性条件下可裂解来合成聚合物。 所得聚合物的主链在低pH下容易降解成许多小分子，但在生理pH下保持相对稳定和完整。 新材料具有在细胞的内体或溶酶体区室内通常发现的条件下能够通过酸水解降解的共同特征，从而释放其在细胞内的有效载荷。 这些材料也可以用于将治疗剂递送到肿瘤和其它炎症部位的酸性区域。
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