公开(公告)号：US20240358748A1

公开(公告)日：2024-10-31

申请号：US18578076

申请日：2022-07-13

申请人： Indena S.P.A.

发明人： Marilu' Tarantino ,  Daniele Ciceri ,  Maurizio Ricotti

IPC分类号： A61K33/26 ,  A61K9/16

CPC分类号： A61K33/26 ,  A61K9/1641 ,  A61K9/1694

摘要： The invention relates to an amorphous solid dispersion comprising ferric maltol and a polymer, and the preparation process thereof.

公开(公告)号：US20240299363A1

公开(公告)日：2024-09-12

申请号：US18665804

申请日：2024-05-16

申请人： Vasilios VOUDOURIS

发明人： Vasilios VOUDOURIS

IPC分类号： A61K31/4184 ,  A61K9/00 ,  A61K9/16

CPC分类号： A61K31/4184 ,  A61K9/0095 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1682 ,  A61K9/1694

摘要： Provided herein are pharmaceutical formulations of dry-powder bendamustine suitable for pharmaceutical use. Also provided are methods of producing dry-powder bendamustine. The pharmaceutical formulations can be used for any disease that is sensitive to treatment with bendamustine, such as neoplastic diseases.

公开(公告)号：US12037456B2

公开(公告)日：2024-07-16

申请号：US17293669

申请日：2019-11-14

申请人： Universiteit Gent

发明人： Richard Hoogenboom ,  Ondrej Sedlacek

IPC分类号： C08G73/02 ,  A61K9/16 ,  A61K47/34 ,  A61K47/59 ,  A61L29/08 ,  C08G85/00

CPC分类号： C08G73/0233 ,  A61K9/1641 ,  A61K47/34 ,  A61K47/59 ,  A61L29/085 ,  C08G85/002 ,  A61L2400/10 ,  A61L2400/18 ,  C08G2150/00

摘要： The present invention, in general, relates to the field of poly(2-oxazolines) (PAOx), more in particular poly(2-methoxymethyl-2-oxazoline) (PMeOMeOX) and poly(2-dimethylamino-2-oxazoline) (PDMAOx). The present invention also provides methods for preparing these PAOx, as well as compositions and uses comprising said PAOx.

公开(公告)号：US20240226010A9

公开(公告)日：2024-07-11

申请号：US18373749

申请日：2023-09-27

申请人： University of Mississippi Medical Center

发明人： Amol V. JANORKAR ,  Jared S. COBB ,  John J. CORREIA ,  Valeria ZAI-ROSE

IPC分类号： A61K9/16 ,  A61K45/06 ,  A61K47/69

CPC分类号： A61K9/1658 ,  A61K9/1641 ,  A61K9/1682 ,  A61K45/06 ,  A61K47/6927

摘要： This disclosure relates to macro- and micro-sized elastin-like polymers (ELP). The addition of a polyethyleneimine (PEI) block to the terminal end of ELP allows the particle radius as well as LCST to be controlled by changing any combination of polymer concentration, ion concentration, and pH. The addition of the PEI block also provides the ability to crosslink the copolymers and achieve a stable particle radius.

公开(公告)号：US20240207453A1

公开(公告)日：2024-06-27

申请号：US18288937

申请日：2022-04-24

申请人： BEIJING RICHEN-FORCE SCIENCE & TECHNOLOGY CO., LTD ,  JIANGSU RICHEN-BASES BIO & SCI CO., LTD.

发明人： Aihua Gong

IPC分类号： A61K49/00 ,  A61K9/16

CPC分类号： A61K49/0004 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1641

摘要： The present invention relates to the field of pharmaceutical preparations, in particular to a 13C-methacetin granule, and a preparation method therefor and the use thereof. Provided is the 13C-methacetin granule, comprising 13C-methacetin, mannitol, a co-solvent and a wetting agent. The 13C-methacetin granule has good stability, is beneficial for storage and the production of subsequent preparations, etc. The 13C-methacetin granule has good water solubility, can be rapidly dissolved in water during clinical use, and is convenient to take. Further provided is the use of the 13C-methacetin granule in the preparation of drugs, reagents or kits for disease diagnosis, evaluation of the liver reserve function and preoperative and postoperative evaluation of the liver. The provided preparation method of the 13C-methacetin granule has mild conditions, simple operation and convenient production control.

公开(公告)号：US20240115565A1

公开(公告)日：2024-04-11

申请号：US18488513

申请日：2023-10-17

申请人： INTRA-CELLULAR THERAPIES, INC.

发明人： Peng LI

IPC分类号： A61K31/4985 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K47/38 ,  A61P3/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28

CPC分类号： A61K31/4985 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0053 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/38 ,  A61P3/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  C07D471/16

摘要： The disclosure provides new, stable, pharmaceutically acceptable amorphous solid dispersions of 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-l-one, together with methods of making and using them, and pharmaceutical compositions comprising them.

公开(公告)号：US11951216B2

公开(公告)日：2024-04-09

申请号：US17677282

申请日：2022-02-22

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Hunter Chen ,  Scott Walsh

IPC分类号： A61K9/50 ,  A61K9/14 ,  A61K9/16 ,  A61K38/17 ,  A61P27/02

CPC分类号： A61K9/5089 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/5031 ,  A61K9/5047 ,  A61K38/179 ,  A61P27/02 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1652

摘要： Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time.

公开(公告)号：US20240099994A1

公开(公告)日：2024-03-28

申请号：US17754738

申请日：2020-12-18

申请人： ALAR PHARMACEUTICAL INC.

发明人： Tong-Ho Lin ,  Yung-Shun Wen ,  Chai-Hsien Chen ,  Ying-Ting Liu ,  Rui-Zhi Hou ,  Zhi-Rong Wu

IPC分类号： A61K31/135 ,  A61K9/00 ,  A61K9/16 ,  A61P25/24

CPC分类号： A61K31/135 ,  A61K9/0019 ,  A61K9/1641 ,  A61P25/24

摘要： Provided are sustained-release pharmaceutical compositions including a ketamine pamoate salt and a pharmaceutically acceptable carrier thereof. The compositions include aqueous suspension, solution and matrix delivery system, which can provide sustained release for anesthesia, analgesia or treatment of central nervous system and anti-inflammatory diseases.

公开(公告)号：US11896715B2

公开(公告)日：2024-02-13

申请号：US17621587

申请日：2020-06-11

申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

发明人： Kwang Dae Hong ,  Jihun Seo ,  Joon Bum Lee

IPC分类号： A61K47/36 ,  A61K47/42 ,  A61K9/16 ,  A61K9/00 ,  A61K9/50

CPC分类号： A61K9/1641 ,  A61K9/0019 ,  A61K9/5026 ,  A61K47/36 ,  A61K47/42

摘要： The present invention relates to an in-vivo bulking agent which can be used as a medicinal agent for prevention or treatment of at least one disease selected from the group consisting of urinary incontinence, fecal incontinence, and gastroesophageal reflux or as a filler for use in a plastic surgery procedure, and to a preparation method therefor. The in-vivo bulking agent can exhibit a bulking effect when injected into the body and particularly, is highly biocompatible because a first composition in which silicone particles are coated with a zwitterionic polymer having a surfactant property is introduced into a second composition, whereby the bulking agent can inhibit inflammatory reactions in vivo.

公开(公告)号：US20230405094A1

公开(公告)日：2023-12-21

申请号：US18037218

申请日：2021-11-17

申请人： Janssen Sciences Ireland Unlimited Company

发明人： René Holm ,  Steven M. Vesole ,  Guenter Karl Wilhelm Kraus

IPC分类号： A61K38/47 ,  A61K9/00 ,  A61K9/10 ,  A61K31/505 ,  A61K9/16 ,  A61P31/18

CPC分类号： A61K38/47 ,  A61K9/0019 ,  A61K9/10 ,  A61K31/505 ,  A61K9/1641 ,  A61K9/1623 ,  A61P31/18 ,  C12Y302/01035

摘要： The present invention relates to the treatment or prevention of a disease or disorder using a drug in the form of micro- or nanoparticles in suspension, in combination with a hyaluronidase.