公开(公告)号：US08580962B2

公开(公告)日：2013-11-12

申请号：US13180166

申请日：2011-07-11

申请人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Luciano Guarneri ,  Davide Graziani ,  Carlo De Toma ,  Katia Dimitrova Karamfilova

发明人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Luciano Guarneri ,  Davide Graziani ,  Carlo De Toma ,  Katia Dimitrova Karamfilova

IPC分类号： A61K31/44 ,  C07D213/00

CPC分类号： C07D498/10 ,  C07D491/10

摘要： The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed.

摘要翻译： 本发明涉及使用选择性代谢型mGlu5受体的拮抗剂治疗哺乳动物下泌尿道神经肌肉功能障碍的方法。 提供了通过施用选择性mGlu5拮抗剂治疗患有下尿路神经肌肉功能障碍的哺乳动物的方法。 选择性mGlu5拮抗剂可以单独施用或与一种或多种用于治疗这种病症的其它治疗剂组合施用。 还提供鉴定可用于治疗哺乳动物下泌尿道神经肌肉功能障碍的选择性mGlu5拮抗剂的方法。 还公开了使用选择性mGlu5拮抗剂治疗偏头痛和胃食管反流病（GERD）的方法。

公开(公告)号：US20120059015A1

公开(公告)日：2012-03-08

申请号：US13180166

申请日：2011-07-11

申请人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Luciano Guarneri ,  Davide Graziani ,  Carlo De Toma ,  Katia Dimitrova Karamfilova

发明人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Luciano Guarneri ,  Davide Graziani ,  Carlo De Toma ,  Katia Dimitrova Karamfilova

IPC分类号： A61K31/423 ,  A61K31/4439 ,  A61P1/04 ,  A61K31/427 ,  A61P13/10 ,  A61P13/00 ,  C07D498/10 ,  A61K31/497

CPC分类号： C07D498/10 ,  C07D491/10

摘要： The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed.

摘要翻译： 本发明涉及使用选择性代谢型mGlu5受体的拮抗剂治疗哺乳动物下泌尿道神经肌肉功能障碍的方法。 提供了通过施用选择性mGlu5拮抗剂治疗患有下尿路神经肌肉功能障碍的哺乳动物的方法。 选择性mGlu5拮抗剂可以单独施用或与一种或多种用于治疗这种病症的其它治疗剂组合施用。 还提供鉴定可用于治疗哺乳动物下泌尿道神经肌肉功能障碍的选择性mGlu5拮抗剂的方法。 还公开了使用选择性mGlu5拮抗剂治疗偏头痛和胃食管反流病（GERD）的方法。