公开(公告)号：US06440954B1

公开(公告)日：2002-08-27

申请号：US09061609

申请日：1998-04-16

申请人： Carol Haber ,  Wen-Sen Lee

发明人： Carol Haber ,  Wen-Sen Lee

IPC分类号： A61K3156

CPC分类号： G01N33/743 ,  A61K31/57 ,  C07J1/00

摘要： Methods of treating a mammal having a condition characterized by vascular smooth muscle cell proliferation, where the mammal is treated with progesterone or an agonist thereof. Also disclosed are methods of screening compounds useful for inhibiting vascular smooth muscle cell proliferation.

公开(公告)号：US20090012020A1

公开(公告)日：2009-01-08

申请号：US11810344

申请日：2007-06-04

申请人： Mu-En Lee ,  Mei Lee ,  Edgar Haber ,  Carol Haber ,  Mark A. Perrella ,  Gokhan S. Hotamisligil

发明人： Mu-En Lee ,  Mei Lee ,  Edgar Haber ,  Carol Haber ,  Mark A. Perrella ,  Gokhan S. Hotamisligil

IPC分类号： A61K31/711 ,  A61P9/10

CPC分类号： C12N15/113 ,  A61K31/711 ,  A61K38/00 ,  C12N2310/111

摘要： The invention features a method of inhibiting formation of atherosclerotic lesions by administering to a mammal, e.g., a human patient who has been identified as suffering from or at risk of developing atherosclerosis, a compound that reduces expression or activity of AFABP.

摘要翻译： 本发明的特征在于通过给已被鉴定为患有或有发展为动脉粥样硬化的风险的哺乳动物，例如降低AFABP的表达或活性的化合物施用来抑制动脉粥样硬化病变形成的方法。