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公开(公告)号：US5985852A
公开(公告)日：1999-11-16
申请号：US250999
申请日：1999-02-16
IPC分类号： A61K9/127 , A61K9/70 , A61K31/70 , A61K31/715 , A61K31/726 , A61K47/44 , A61K47/48 , A61P9/00 , A61P9/10 , A61P11/06 , A61P29/00 , A61P35/04 , A61P43/00 , C07H1/00
CPC分类号： A61K31/7024 , A61K9/1273
摘要： This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, these composition scan be used to palliate certain inflammatory and immunological conditions.
摘要翻译： 本发明提供用于抑制两个细胞之间的结合的组合物，一个在表面上表达P-或L-选择蛋白，另一个表达相应的配体。 制备在单独的脂质上具有糖和酸性基团的共价交联的脂质组合物。 然后将组合物置于细胞之间以抑制结合。 可以在低于游离糖的106倍的有效寡糖浓度下实现抑制。 由于选择素参与将细胞募集到损伤部位，所以这些组合物扫描可用于缓解某些炎症和免疫条件。
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公开(公告)号：US06299897B1
公开(公告)日：2001-10-09
申请号：US09440880
申请日：1999-11-15
IPC分类号： A61K970
CPC分类号： A61K31/7024 , A61K9/1273
摘要： This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 106 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, these composition scan be used to palliate certain inflammatory and immunological conditions.
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