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    Pharmaceutical compositions and therapeutic applications for the use of a synthetic vitamin B12 derivative, glutathionylcobalamin
    1.
    发明申请
    Pharmaceutical compositions and therapeutic applications for the use of a synthetic vitamin B12 derivative, glutathionylcobalamin 审中-公开
    用于合成维生素B12衍生物，谷胱甘肽钴胺素的药物组合物和治疗应用

    公开(公告)号：US20080113900A1

    公开(公告)日：2008-05-15

    申请号：US11901983

    申请日：2007-09-20

    申请人： Nicola Brasch ,  Catherine Birch ,  John Williams

    发明人： Nicola Brasch ,  Catherine Birch ,  John Williams

    IPC分类号： A61K38/06 ,  A61P25/00 ,  A61P25/28 ,  A61P27/06 ,  A61P9/00

    CPC分类号： A61K38/063 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, glutathionylcobalamin to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as glutathionylcobalamin, in lieu of current, commercially available forms of vitamin B12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.

    摘要翻译： 治疗应用，如预防，治疗和补充，用于使用新型和其他硫胺素类维生素来保护人类细胞免受氧化应激的影响。 特别地，本发明涉及一种新的合成硫胺素类巴马酸，谷胱甘肽钴胺素保护动物细胞免受氧化应激损伤的用途。 本发明还涉及硫胺素类维生素如谷胱甘肽钴胺素代替当前市售形式的维生素B 12，用于治疗和预防与氧化应激损伤和膳食补充相关的病症。

    Pharmaceutical compositions and therapeutic applications for the use of a novel vitamin B12 derivative, N-acetyl-L-cysteinylcobalamin
    2.
    发明申请
    Pharmaceutical compositions and therapeutic applications for the use of a novel vitamin B12 derivative, N-acetyl-L-cysteinylcobalamin 有权
    用于使用新型维生素B12衍生物，N-乙酰基-L-半胱氨酰钴胺素的药物组合物和治疗应用

    公开(公告)号：US20080076733A1

    公开(公告)日：2008-03-27

    申请号：US11903066

    申请日：2007-09-20

    申请人： Nicola Brasch ,  Catherine Birch ,  John Williams

    发明人： Nicola Brasch ,  Catherine Birch ,  John Williams

    IPC分类号： A61K31/7042 ,  A61P25/28 ,  A61P27/06 ,  A61P9/00

    CPC分类号： A61K31/7042

    摘要： Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, N-acetyl-L-cysteinylcobalamin (NACCbl) to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as NACCbl, in lieu of current, commercially available forms of vitamin B12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.

    摘要翻译： 治疗应用，如预防，治疗和补充，用于使用新型和其他硫胺素类维生素来保护人类细胞免受氧化应激的影响。 特别地，本发明涉及一种新的合成硫胺素一精胺N-乙酰基-L-半胱氨酰钴胺素（NACCbl）用于保护动物细胞免受氧化应激损伤的用途。 本发明还涉及硫胺素类维生素如NACCbl的用途，代替目前市售的维生素B 12的形式，用于治疗和预防与氧化应激损伤和膳食补充相关的病症。