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    Pharmaceutical compositions and therapeutic applications for the use of a synthetic vitamin B12 derivative, glutathionylcobalamin
    1.
    发明申请
    Pharmaceutical compositions and therapeutic applications for the use of a synthetic vitamin B12 derivative, glutathionylcobalamin 审中-公开
    用于合成维生素B12衍生物，谷胱甘肽钴胺素的药物组合物和治疗应用

    公开(公告)号：US20080113900A1

    公开(公告)日：2008-05-15

    申请号：US11901983

    申请日：2007-09-20

    申请人： Nicola Brasch ,  Catherine Birch ,  John Williams

    发明人： Nicola Brasch ,  Catherine Birch ,  John Williams

    IPC分类号： A61K38/06 ,  A61P25/00 ,  A61P25/28 ,  A61P27/06 ,  A61P9/00

    CPC分类号： A61K38/063 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, glutathionylcobalamin to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as glutathionylcobalamin, in lieu of current, commercially available forms of vitamin B12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.

    摘要翻译： 治疗应用，如预防，治疗和补充，用于使用新型和其他硫胺素类维生素来保护人类细胞免受氧化应激的影响。 特别地，本发明涉及一种新的合成硫胺素类巴马酸，谷胱甘肽钴胺素保护动物细胞免受氧化应激损伤的用途。 本发明还涉及硫胺素类维生素如谷胱甘肽钴胺素代替当前市售形式的维生素B 12，用于治疗和预防与氧化应激损伤和膳食补充相关的病症。

    Pharmaceutical compositions and therapeutic applications for the use of a novel vitamin B12 derivative, N-acetyl-L-cysteinylcobalamin
    2.
    发明申请
    Pharmaceutical compositions and therapeutic applications for the use of a novel vitamin B12 derivative, N-acetyl-L-cysteinylcobalamin 有权
    用于使用新型维生素B12衍生物，N-乙酰基-L-半胱氨酰钴胺素的药物组合物和治疗应用

    公开(公告)号：US20080076733A1

    公开(公告)日：2008-03-27

    申请号：US11903066

    申请日：2007-09-20

    申请人： Nicola Brasch ,  Catherine Birch ,  John Williams

    发明人： Nicola Brasch ,  Catherine Birch ,  John Williams

    IPC分类号： A61K31/7042 ,  A61P25/28 ,  A61P27/06 ,  A61P9/00

    CPC分类号： A61K31/7042

    摘要： Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, N-acetyl-L-cysteinylcobalamin (NACCbl) to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as NACCbl, in lieu of current, commercially available forms of vitamin B12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.

    摘要翻译： 治疗应用，如预防，治疗和补充，用于使用新型和其他硫胺素类维生素来保护人类细胞免受氧化应激的影响。 特别地，本发明涉及一种新的合成硫胺素一精胺N-乙酰基-L-半胱氨酰钴胺素（NACCbl）用于保护动物细胞免受氧化应激损伤的用途。 本发明还涉及硫胺素类维生素如NACCbl的用途，代替目前市售的维生素B 12的形式，用于治疗和预防与氧化应激损伤和膳食补充相关的病症。

    Distributed facultative bacteria water treatment system with membrane biological reactor package plant augmentation
    3.
    发明授权
    Distributed facultative bacteria water treatment system with membrane biological reactor package plant augmentation 有权
    分布式兼性细菌水处理系统与膜生物反应器包装植物增加

    公开(公告)号：US08828229B2

    公开(公告)日：2014-09-09

    申请号：US13252832

    申请日：2011-10-04

    申请人： John Williams ,  Daniel R. Williamson, Jr. ,  J. Rodney Dickerson ,  Guy Marchesseault ,  Robert C. Fischer

    发明人： John Williams ,  Daniel R. Williamson, Jr. ,  J. Rodney Dickerson ,  Guy Marchesseault ,  Robert C. Fischer

    IPC分类号： C02F11/12 ,  B01D61/12 ,  C02F3/34 ,  C02F3/30 ,  C02F1/32

    CPC分类号： C02F3/1268 ,  C02F1/32 ,  C02F3/302 ,  C02F3/348 ,  C02F2209/005 ,  C02F2305/06 ,  Y02W10/15

    摘要： The invention is directed to wastewater treatment and wastewater reuse. A distributed biological treatment system for modification of the sewer biofilm through the mechanism of competitive exclusion by strategic dosing with facultative bacteria is illustrated, in conjunction with a novel membrane biological reactor (MBR)/biological breeding reactor (BBR) package plant, a plurality of which are likewise designed for strategic placement throughout the sewer/collection system infrastructure. The inclusion of the MBR/BBR plants at specific locations within the distribution system provide upstream water reclamation, thereby facilitating more efficient operation of the downstream wastewater treatment plant and providing for water reuse at intermediate points within the distribution network, as well as a means for concentrating the facultative bacteria which has been dosed to various points in the system, which can then be re-inoculated to the system.

    摘要翻译： 本发明涉及废水处理和废水再利用。 结合新型膜生物反应器（MBR）/生物繁殖反应器（BBR）包装厂，结合新鲜的膜生物反应器（MBR）/生物繁殖反应器（BBR）包装厂，分析了通过与兼性细菌进行战略性给药的竞争性排除机制来改造下水道生物膜的分布式生物处理系统 它们同样设计用于整个污水/收集系统基础设施的战略布置。 在分配系统内的特定位置包括MBR / BBR设备提供上游回水，从而有助于下游污水处理厂的更有效运行，并为配送网络中的中间点提供水回用，以及 浓缩已经配制到系统中的各个点的兼性细菌，然后可以将其再次接种到系统中。

    System and Method of Electronic Tracking and Information Retrieval for the Integrity and Testing of Radiopharmaceutical Personal Protective Equipment
    4.
    发明申请
    System and Method of Electronic Tracking and Information Retrieval for the Integrity and Testing of Radiopharmaceutical Personal Protective Equipment 审中-公开
    电子跟踪和信息检索系统和方法，用于放射性药物个人防护装备的完整性和测试

    公开(公告)号：US20140149299A1

    公开(公告)日：2014-05-29

    申请号：US13684771

    申请日：2012-11-26

    申请人： John Williams ,  Chetan S. Karani

    发明人： John Williams ,  Chetan S. Karani

    IPC分类号： G06Q10/00 ,  G06Q50/22

    CPC分类号： G06Q50/22 ,  G06Q10/06 ,  G06Q10/0833 ,  G06Q10/087

    摘要： An equipment inspection tracking system and method for radiopharmaceutical personal protective equipment which has a read-only RFID tag and a database management system that allows a user to track, update, review and report a record of standard tracking and compliance history information. The system and method are customizable and can be used for large and varied quantities of radiopharmaceutical personal protective equipment. The system and method allow access by safety officers and compliance inspectors for required regulatory reporting. The system and method are accessible through a web browser or mobile application.

    摘要翻译： 一种用于放射性药物个人防护装备的设备检查跟踪系统和方法，其具有只读RFID标签和数据库管理系统，其允许用户跟踪，更新，审查和报告标准跟踪和合规历史信息的记录。 该系统和方法是可定制的，可用于大量和多种量的放射性药物个人防护装备。 该系统和方法允许安全官员和合规检查人员进行所需的监管报告。 系统和方法可通过网络浏览器或移动应用程序访问。

    Edge assemblies for slate and tile roofs
    5.
    发明授权
    Edge assemblies for slate and tile roofs 有权
    用于石板和瓦屋顶的边缘组件

    公开(公告)号：US08661761B2

    公开(公告)日：2014-03-04

    申请号：US13484380

    申请日：2012-05-31

    申请人： John Williams

    发明人： John Williams

    IPC分类号： E04D1/34

    CPC分类号： E04D1/34 ,  E04D13/0459 ,  E04D2001/3411 ,  E04D2001/3414 ,  E04D2001/3438 ,  E04D2001/3458 ,  E04D2001/3473 ,  E04D2013/0468

    摘要： An integral roof and gable edge assembly includes a metal or plastic sheet formed with positioning surfaces to facilitate slate tile installation by relatively unskilled roofers. The roof and gable assemblies include one or more hooks for holding one or more slate, ceramic or other similar roofing tiles in fixed position along the eaves and/or gables of a roof. A lift arm can be provided on the roof assemblies to replace cant strips and simplify tile installation. Tiles can be easily installed without nailing through the tiles.

    摘要翻译： 一体化的屋顶和山墙边缘组件包括形成有定位表面的金属或塑料片，以便于由相对不熟练的屋顶材料安装石板瓦。 屋顶和山墙组件包括一个或多个钩，用于沿屋顶的屋檐和/或山墙保持固定位置的一个或多个板岩，陶瓷或其它类似的屋顶瓦。 可以在屋顶组件上提供一个提升臂，以更换斜板，并简化瓦片的安装。 瓦片可以轻松安装，无需穿过瓷砖。

    Method for using modifiable tool control parameters to control the temperature of the tool during friction stir welding
    10.
    发明授权
    Method for using modifiable tool control parameters to control the temperature of the tool during friction stir welding 有权
    在摩擦搅拌焊接时使用可修改的刀具控制参数来控制刀具温度的方法

    公开(公告)号：US07909231B2

    公开(公告)日：2011-03-22

    申请号：US12539595

    申请日：2009-08-11

    申请人： Jonathan A. Babb ,  Russell Steel ,  Scott M. Packer ,  John Williams

    发明人： Jonathan A. Babb ,  Russell Steel ,  Scott M. Packer ,  John Williams

    IPC分类号： B23K31/02 ,  B23K20/12

    CPC分类号： B23K20/1235

    摘要： A new control variable is introduced, that when combined with previous dependent control criteria on other variables results in a control program that can create a superior weld while minimizing wear on the FSW tool, wherein the tool repeatedly experiences the same thermal and mechanical loading within specified control windows during every repeated weld sequence because flow stresses and tool loads are driven by temperature, and dependent control loops account for differences in material and heat that is transferred at different rates in varying locations throughout a friction stir weld.

    摘要翻译： 引入了一个新的控制变量，当与其他变量上的先前的依赖控制标准相结合时，可以创建一个控制程序，该控制程序可以在最小化FSW工具的磨损的同时创建优异的焊缝，其中工具反复经历相同的热和机械负荷 由于流动应力和工具负载由温度驱动，所以在每个重复的焊接顺序期间控制窗口，并且相关的控制回路考虑到在整个摩擦搅拌焊接处不同位置以不同速率传递的材料和热量的差异。