公开(公告)号：US20220208421A1

公开(公告)日：2022-06-30

申请号：US17206441

申请日：2021-03-19

申请人： Chapman University

发明人： Armen Gulian ,  Rajendra Dulal ,  Yasushi Kawashima ,  Serafim Teknowijoyo ,  Sara Chahid

IPC分类号： H01F1/00 ,  H01F10/28 ,  H01F10/30 ,  H01F10/14 ,  H01F41/22

摘要： Systems, methods, and apparatus for generating an ideal diamagnetic response are disclosed. A disclosed diamagnetic system includes a metal foil or a first substrate having at least one surface that is coated by a metallic layer (e.g., permalloy). The diamagnetic system also includes a second substrate having at least one surface that is coated by graphene. The first and second substrates are immersed in an alkane (e.g., n-heptane). The diamagnetic system produces a diamagnetic response at room temperature in an applied magnetic field when the alkane is added to surround the permalloy and graphene.

公开(公告)号：US11464748B2

公开(公告)日：2022-10-11

申请号：US16074643

申请日：2017-01-31

申请人： Emory University ,  Georgia Tech Research Corporation ,  Chapman University ,  Children's Healthcare of Atlanta, Inc.

发明人： Wilbur A. Lam ,  Caroline Hansen ,  Yumiko Sakurai ,  Andrew Lyon

IPC分类号： A61K9/50 ,  A61K38/37

摘要： This disclosure relates to microcapsule particles for targeted delivery of drugs. In certain embodiments, the particles comprise polyelectrolyte polymers, e.g., layers of anionic polymers and cationic polymers. In certain embodiments, the particles have a fibrinogen coating. In certain embodiments, the particles contain a polysaccharide core and/or a polysaccharide coating encapsulating drugs, proteins, clotting agents, coagulation factors, or anticoagulants. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of or duration of bleeding. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of blood clotting.

公开(公告)号：US20220265839A1

公开(公告)日：2022-08-25

申请号：US17673519

申请日：2022-02-16

申请人： Chapman University

发明人： Saghar Mozaffari ,  David Salehi ,  Parvin Mahdipoor ,  Rakesh Tiwari ,  Hamidreza Montazeri Aliabadi ,  Keykavous Parang ,  Khalid Zoghebi

IPC分类号： A61K47/64 ,  A61K31/704 ,  A61P35/00

摘要： Provided herein are drug delivery systems comprising a peptide targeting agent and a pharmaceutical agent for delivery of chemotherapeutic agents. Also provided are methods of treating cancer comprising administration of the drug delivery system disclosed herein.

公开(公告)号：US20210259954A1

公开(公告)日：2021-08-26

申请号：US17105949

申请日：2020-11-27

申请人： Chapman University

发明人： Rajasekharreddy Pala ,  Surya M. Nauli

IPC分类号： A61K9/00 ,  A61P9/12 ,  A61K9/50 ,  A61K9/51 ,  C07K16/28 ,  A61K39/395 ,  A61K31/55

摘要： Disclosed herein are cilia-targeting nanoparticles and methods of treating ciliopathies.

公开(公告)号：US20210259579A1

公开(公告)日：2021-08-26

申请号：US17181238

申请日：2021-02-22

申请人： Chapman University

发明人： Marybeth Grant-Beuttler ,  Rahul Soangra

IPC分类号： A61B5/103 ,  A61B5/11 ,  A61B5/00

摘要： A wearable system for treating a child patient with Idiopathic Toe Walking (“ITW”) is disclosed herein. A disclosed system includes a wearable shoe insole, a first pressure sensor located at a heel region of the shoe insole, a second pressure sensor located at a front region of the shoe insole, and a vibration actuator included within the shoe insole. The disclosed system may also include an inertial measurement unit. The disclosed system further includes a processor that receives data from the pressure sensors and/or the inertial measurement unit. The processor determines a gait pattern of the child patient based on the received data. Indicative of determining the gait pattern is a toe-to-toe gait pattern, the processor causes the vibration actuator to provide haptic feedback to the child patient for correcting their tow walking gait.

公开(公告)号：US20200306199A1

公开(公告)日：2020-10-01

申请号：US16074643

申请日：2017-01-31

申请人： Emory University ,  Georgia Tech Research Corporation ,  Chapman University ,  Children's Healthcare of Atlanta, Inc.

发明人： Wilbur A. Lam ,  Caroline Hansen ,  Yumiko Sakurai ,  Andrew Lyon

IPC分类号： A61K9/50 ,  A61K38/37

摘要： This disclosure relates to microcapsule particles for targeted delivery of drugs. In certain embodiments, the particles comprise polyelectrolyte polymers, e.g., layers of anionic polymers and cationic polymers. In certain embodiments, the particles have a fibrinogen coating. In certain embodiments, the particles contain a polysaccharide core and/or a polysaccharide coating encapsulating drugs, proteins, clotting agents, coagulation factors, or anticoagulants. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of or duration of bleeding. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of blood clotting.

公开(公告)号：US11597962B2

公开(公告)日：2023-03-07

申请号：US16763902

申请日：2018-11-14

申请人： Chapman University

发明人： Kamaljit Kaur ,  Hanieh Hossein-Nejad-Ariani

IPC分类号： C12Q1/06 ,  G01N33/569

摘要： A rapid assay for determining the presence of bacteria in a sample, such as a contaminated food sample, is disclosed. The assay comprises contacting the sample with a bacteria-specific ligand associated with a substrate, wherein bacteria present in the sample bind the ligand; contacting the bound bacteria with a detection agent; detecting the presence of bacteria in the sample by measuring the quantity of detection agent associated with the sample.

公开(公告)号：US20230017126A1

公开(公告)日：2023-01-19

申请号：US17942928

申请日：2022-09-12

申请人： Northwestern University ,  Chapman University

发明人： Richard B. Silverman ,  Sun Yang

IPC分类号： A61K31/47 ,  A61K31/381 ,  A61P35/00

摘要： Disclosed herein are methods and compositions for administering immunotherapy to a subject in need thereof and for treating a subject in need thereof, where in the methods the subject is administered an effective amount of an inhibitor of nNOS for inducing an immunotherapeutic response in the subject and for treating the subject. The disclosed methods and composition may be utilized for treating a subject having a cell proliferative disease or disorder such as melanoma.

公开(公告)号：US11439632B2

公开(公告)日：2022-09-13

申请号：US16703009

申请日：2019-12-04

申请人： Northwestern University ,  Chapman University

发明人： Richard B. Silverman ,  Sun Yang

IPC分类号： A61K31/47 ,  A61K31/381 ,  A61P35/00 ,  A61K31/495 ,  C07K16/28 ,  A61K31/4164 ,  A61K38/21

摘要： Disclosed herein are methods and compositions for administering immunotherapy to a subject in need thereof and for treating a subject in need thereof, where in the methods the subject is administered an effective amount of an inhibitor of nNOS for inducing an immunotherapeutic response in the subject and for treating the subject. The disclosed methods and composition may be utilized for treating a subject having a cell proliferative disease or disorder such as melanoma.

公开(公告)号：US20210246019A1

公开(公告)日：2021-08-12

申请号：US17170785

申请日：2021-02-08

申请人： Chapman University

发明人： Hamidreza Montazeri Aliabadi ,  Keykavous Parang ,  Ryley Hall ,  Abdulaziz Alasmari

IPC分类号： B82Y5/00 ,  A61K47/54 ,  A61K47/69 ,  A61K47/26 ,  A61K47/18

摘要： Disclosed are compositions and methods for delivering nucleic acids and other substances into living cells. The compositions constitute a delivery system comprising a peptide component with hydrophobic and positively-charged portions, and a lipid component. Any nucleic acid can be delivered including siRNA, mRNA, and DNA. The delivered nucleic acid can have therapeutic or prophylactic effect.