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公开(公告)号：US06656162B2
公开(公告)日：2003-12-02
申请号：US10314838
申请日：2002-12-09
IPC分类号： A61M500
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release.
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公开(公告)号：US07041130B2
公开(公告)日：2006-05-09
申请号：US10768315
申请日：2004-01-30
IPC分类号： A61F2/06
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Devices for the controlled release of one or more drugs into a patient are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system may have one or more drugs for release at a controlled rate. Reservoir caps optionally are provided to control the time at which release of the one or more drugs is initiated.
摘要翻译： 提供了将一种或多种药物控制释放到患者体内的装置。 所述装置包括可植入支架，所述支架中的至少两个储存器和包含在所述至少两个储存器中的每一个中的释放系统，其中所述释放系统可以具有一种或多种以受控速率释放的药物。 可选地提供储存器盖以控制开始一种或多种药物释放的时间。
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公开(公告)号：US06537256B2
公开(公告)日：2003-03-25
申请号：US10195338
申请日：2002-07-15
申请人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61M500
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Apparatus and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparatus include microchip devices which have reservoirs containing the molecules for release. The apparatus and methods provide for active or passive controlled release of the molecules. Embodiments include systems for release of fragrance molecules and beverage additives.
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公开(公告)号：US06394739B1
公开(公告)日：2002-05-28
申请号：US09802030
申请日：2001-03-08
IPC分类号： B66C130
摘要： An attachment for use with a skid loader for lifting and transporting stacks of strapped blocks which includes a frame having an upper and lower horizontal bar, a pair of arms pivotally mounted with the upper bar which are in sliding engagement with the lower bar. A drive member is carried by the frame between the arms for moving the arms between a disengaged and an engaged position. A foot assembly which includes first and second legs and a grabber foot is connected with each of the arms. Each grabber foot includes a planar inner face and is pivotally mounted with a second leg to extend substantially perpendicularly of the associated arm with its inner face canting slightly upwardly and outwardly.
摘要翻译： 一种与用于提升和运输捆绑块堆叠的滑移装载机的附件，其包括具有上下水平杆的框架，与所述上杆可枢转地安装的一对臂，其与所述下杆滑动接合。 驱动构件由框架支撑在臂之间，用于在分离和接合位置之间移动臂。 包括第一和第二腿部以及抓取脚的脚组件与每个臂连接。 每个抓取脚包括平坦的内表面，并且枢转地安装有第二腿，以大致垂直于相关联的臂延伸，其内表面稍微向上和向外倾斜。
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公开(公告)号：US20110245914A1
公开(公告)日：2011-10-06
申请号：US13112779
申请日：2011-05-20
IPC分类号： A61F2/82
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release.
摘要翻译： 提供用于控制释放一种或多种药物的装置。 所述装置包括可植入支架，所述支架中的至少两个储存器和包含在所述至少两个储存器中的每一个中的释放系统，其中所述释放系统包括一种或多种用于释放的药物。
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6.发明授权公开(公告)号：US06491666B1
公开(公告)日：2002-12-10
申请号：US09715493
申请日：2000-11-17
申请人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61M500
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Apparati and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparati include microchip devices which have reservoirs containing the molecules for release. The apparati and methods provide for active or passive controlled release of the molecules. Preferred embodiments include systems for intravenous administration of drugs, wherein drug molecules are released from the microchip devices into a carrier fluid ex vivo, such as a saline solution, forming a drug/saline solution mixture which is then delivered to a patient intravenously.
摘要翻译： 提供了通过载体流体将分子递送到部位的方法和方法。 该装置包括具有含有释放分子的储存器的微芯片装置。 该设备和方法提供分子的主动或被动控制释放。 优选的实施方案包括用于静脉内施用药物的系统，其中药物分子从微芯片装置释放到离体的载体液体中，例如盐水溶液，形成药物/盐溶液混合物，然后静脉内递送给患者。
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