公开(公告)号：US07678887B2

公开(公告)日：2010-03-16

申请号：US11705672

申请日：2007-02-13

申请人： Charles G. Todderud ,  Joshua N. Finger ,  Jill Rillema

发明人： Charles G. Todderud ,  Joshua N. Finger ,  Jill Rillema

IPC分类号： A61K51/00 ,  G01N33/566 ,  C07K1/00

CPC分类号： C07K14/47

摘要： The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

摘要翻译： 本发明描述了一种新发现的多核苷酸，其编码参与由TNF-α刺激的人微血管内皮细胞以及小鼠和大鼠RET16直系同源物克隆，分离和鉴定的细胞信号级联的称为RET16的蛋白质。 还描述了与本发明的多核苷酸和/或多肽相关的RET16多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 描述了用于筛选人RET16蛋白的调节剂，特别是抑制剂的方法，以及RET16多核苷酸和多肽用于治疗和诊断的用途。