公开(公告)号：US08906282B2

公开(公告)日：2014-12-09

申请号：US11176654

申请日：2005-07-06

Applicant: Bee Eng Mary Chan ,  Jinye Shen ,  Bin He ,  Aiping Zhu ,  Yehai Yan ,  Chee Yoon Yue

Inventor： Bee Eng Mary Chan ,  Jinye Shen ,  Bin He ,  Aiping Zhu ,  Yehai Yan ,  Chee Yoon Yue

IPC: B27N3/08 ,  B29C41/00 ,  B28B7/30 ,  A61F2/00 ,  A61K9/14 ,  B29C33/38 ,  B29C33/42

CPC classification number: B29C33/3857 ,  B29C33/424

Abstract: In embodiments of the present invention, a biodegradable/biodegradable polymer film may be used as a scaffold for tissue engineering scaffolds for engineering organized organs, such as vascular grafts, for example. In one embodiment, an ultraviolet (UV) resin made from a diacrylated biodegradable oligomer is molded into a flexible scaffold having cavities and/or channels. Channel/cavity size may be on the order of micrometers and/or nanometers, and thus the walls may have high aspect ratios. Smooth muscle cells may be deposited in the channels and because of the high aspect ratios, the cells may align along the channels/cavities as confluence is reached.

Abstract translation: 在本发明的实施方案中，可生物降解/可生物降解的聚合物膜可用作用于组织工程支架的支架，用于工程组织的器官，例如血管移植物。 在一个实施方案中，由二丙烯酸酯化的可生物降解的低聚物制成的紫外线（UV）树脂被模制成具有空腔和/或通道的柔性支架。 通道/腔尺寸可以在微米级和/或纳米级上，因此壁可具有高纵横比。 平滑肌细胞可以沉积在通道中，并且由于高纵横比，当达到汇合时，细胞可以沿着通道/腔排列。