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1.发明授权Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor 有权在转移性胰腺肿瘤中实现肿瘤质量和大小消退的方法公开(公告)号：US07795205B2
公开(公告)日：2010-09-14
申请号：US11099370
申请日：2005-04-04
申请人： Cheng-Der Tony Yu
发明人： Cheng-Der Tony Yu
IPC分类号： A01N37/18
CPC分类号： A61K38/58 , A61K2300/00
摘要： The present invention relates generally to methods of inhibiting angiogenesis in a patient by administering an effective angiogenesis-inhibiting amount of a thrombin inhibitor, and to the treatment of disease states that result from uncontrolled cell proliferation by administering a thrombin inhibitor alone or co-administering a thrombin inhibitor with an anticancer or cytotoxic agent. Specifically, the thrombin inhibitors used in the methods of the present invention are hirudins.
摘要翻译： 本发明一般涉及通过施用有效的血管生成抑制量的凝血酶抑制剂和通过单独施用凝血酶抑制剂或共同施用治疗由不受控制的细胞增殖而引起的疾病状态来抑制患者血管生成的方法 具有抗癌剂或细胞毒性剂的凝血酶抑制剂。 具体地，本发明的方法中使用的凝血酶抑制剂是水蛭素。
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公开(公告)号：US09259450B2
公开(公告)日：2016-02-16
申请号：US13186956
申请日：2011-07-20
CPC分类号： A61K36/48 , A61K31/43 , A61K2035/115 , A61K2300/00
摘要： The present invention relates to use of a fermented soy extract as a prebiotic composition to protect beneficial bacteria in the gastrointestinal tract of an animal. Particularly, the fermented soy extract of the invention exhibits the prebiotic activity even under an antibiotic treatment. Also disclosed is combined use of an antibiotic and the fermented soy extract of the invention, which has advantages over administration of the antibiotic alone, such as decreasing the effective dose of the antibiotic and/or reducing side effects resulting from the antibiotic treatment.
摘要翻译： 本发明涉及发酵大豆提取物作为益生元组合物来保护动物胃肠道中的有益细菌的用途。 特别地，本发明的发酵大豆提取物即使在抗生素治疗下也显示益生元活性。 还公开了本发明的抗生素和发酵大豆提取物的组合使用，其具有优于单独使用抗生素的优点，例如降低抗生素的有效剂量和/或减少由抗生素治疗引起的副作用。
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公开(公告)号：US20120058104A1
公开(公告)日：2012-03-08
申请号：US13186956
申请日：2011-07-20
CPC分类号： A61K36/48 , A61K31/43 , A61K2035/115 , A61K2300/00
摘要： The present invention relates to use of a fermented soy extract as a prebiotic composition to protect beneficial bacteria in the gastrointestinal tract of an animal. Particularly, the fermented soy extract of the invention exhibits the prebiotic activity even under an antibiotic treatment. Also disclosed is combined use of an antibiotic and the fermented soy extract of the invention, which has advantages over administration of the antibiotic alone, such as decreasing the effective dose of the antibiotic and/or reducing side effects resulting from the antibiotic treatment.
摘要翻译： 本发明涉及发酵大豆提取物作为益生元组合物来保护动物胃肠道中的有益细菌的用途。 特别地，本发明的发酵大豆提取物即使在抗生素治疗下也显示益生元活性。 还公开了本发明的抗生素和发酵大豆提取物的组合使用，其具有优于单独使用抗生素的优点，例如降低抗生素的有效剂量和/或减少由抗生素治疗引起的副作用。
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4.发明授权Methods for making pharmaceutical dosage forms containing active cushioning components 失效制备含有活性缓冲组分的药物剂型的方法公开(公告)号：US08110223B2
公开(公告)日：2012-02-07
申请号：US10749339
申请日：2003-12-31
申请人： Larry Augsburger , Ngoc Do , Min Michael He , Cheng Der Tony Yu
发明人： Larry Augsburger , Ngoc Do , Min Michael He , Cheng Der Tony Yu
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/0095 , A61K9/1652 , A61K9/2081 , A61K9/2095 , A61K31/573
摘要： Novel methods for making dosages form comprising a cushioning component. The methods of the present invention provides dosage forms which can be compressed to form compressed dosage forms that are substantially uniform in composition and robust and exhibit reduced friability. The invention also relates to methods for making fast-disintegrating dosage forms.
摘要翻译： 用于制备包含缓冲组分的剂型的新方法。 本发明的方法提供了可以被压缩形成压缩剂型的剂型，所述压制剂型在组成上基本上均匀且坚固并且表现出降低的脆性。 本发明还涉及制备快速崩解剂型的方法。
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公开(公告)号：US20090269422A1
公开(公告)日：2009-10-29
申请号：US12468700
申请日：2009-05-19
申请人： CHENG-DER TONY YU
发明人： CHENG-DER TONY YU
CPC分类号： A61K38/58 , A61K2300/00
摘要： The present invention relates generally to methods of inhibiting angiogenesis in a patient by administering an effective angiogenesis-inhibiting amount of a thrombin inhibitor, and to the treatment of disease states that result from uncontrolled cell proliferation by administering a thrombin inhibitor alone or co-administering a thrombin inhibitor with an anticancer or cytotoxic agent. Specifically, the thrombin inhibitors used in the methods of the present invention are hirudins.
摘要翻译： 本发明一般涉及通过施用有效的血管生成抑制量的凝血酶抑制剂和通过单独施用凝血酶抑制剂或共同施用治疗由不受控制的细胞增殖而引起的疾病状态来抑制患者血管生成的方法 具有抗癌剂或细胞毒性剂的凝血酶抑制剂。 具体地，本发明的方法中使用的凝血酶抑制剂是水蛭素。
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6.发明申请METHODS FOR EFFECTING REGRESSION OF TUMOR MASS AND SIZE IN A METASTASIZED TUMOR 审中-公开在肿瘤肿瘤中影响肿瘤大小和大小的回归方法公开(公告)号：US20110224150A1
公开(公告)日：2011-09-15
申请号：US12880981
申请日：2010-09-13
申请人： Cheng-Der Tony YU
发明人： Cheng-Der Tony YU
CPC分类号： A61K38/58 , A61K2300/00
摘要： The present invention relates generally to methods of effecting regression of tumor size and mass of a metastasized tumor in a subject by administering an effective amount of a desulphatohirudin variant.
摘要翻译： 本发明一般涉及通过施用有效量的脱硫水蛭素变体来实现受试者肿瘤大小和质量的消退的方法。
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7.发明授权Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage 失效当药物和/或渗透增强剂在长期储存期间组合不稳定时，使用渗透促进剂增强药物皮肤渗透的方法和组合物
公开(公告)号：US6019988A
公开(公告)日：2000-02-01
申请号：US751293
申请日：1996-11-18
申请人： Prakash Parab , Cheng Der Tony Yu , Bhiku Patel
发明人： Prakash Parab , Cheng Der Tony Yu , Bhiku Patel
CPC分类号： A61K9/06 , A61K9/7023
摘要： The invention provides methods and means for enhancing the epidermal, transdermal and dermal permeation of a topically applied pharmacologically active agent (e.g., a drug or medicament) which has a low rate of skin penetration in the absence of a permeation enhancer and which is unstable and degrades during long-term storage with particular permeation enhancers. Also provided by the invention are methods and means to increase the skin penetration of a pharmacologically active agent which has a normally low rate of skin permeation and causes the instability and degradation of a permeation enhancer with which it is combined over a long period of time. Provided by the invention are at least one first composition containing a drug, a pharmaceutically acceptable salt, chemical derivative or formulation thereof, in a dermatologically acceptable vehicle, and at least one second composition containing a permeation enhancer in an acceptable vehicle. The compositions are physically separated until application to a body or skin surface and are topically applied, either at the same time, or sequentially within a short time of each other, and mixed or blended to form a final active composition, preferably on the skin. In addition, a premixture of the compositions can be made and applied to the skin in accordance with the invention. The invention allows a therapeutically effective amount of drug to be delivered into the skin and systemic circulation and provides significant enhancement of a drug's otherwise low level of skin permeation by the action of permeation enhancer in the active composition at the point of use.
摘要翻译： 本发明提供用于增强局部施用的药理活性剂（例如药物或药物）的表皮，透皮和皮肤渗透的方法和手段，其在不存在渗透促进剂的情况下具有低的皮肤渗透率，并且其不稳定和 在长期储存期间，使用特定的渗透促进剂会降解。 本发明还提供增加药物活性剂的皮肤渗透性的方法和手段，所述药理活性剂通常具有通常低的皮肤渗透速率并导致长时间混合的渗透促进剂的不稳定性和降解性。 通过本发明提供了至少一种含有药物，药学上可接受的盐，化学衍生物或其制剂，在皮肤病学可接受的载体中的第一组合物和至少一种含有可接受载体中的渗透促进剂的第二组合物。 物理分离组合物，直到施用于身体或皮肤表面，并且在相互之间或相互之间相互短时间内局部施用，并混合或混合以形成最终活性组合物，优选在皮肤上。 此外，根据本发明，可以制备并施用组合物的预混物到皮肤。 本发明允许治疗有效量的药物被递送到皮肤和全身循环中，并且在使用时通过渗透促进剂在活性组合物中的作用提供药物的另外低水平的皮肤渗透的显着增强。
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