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1.发明授权公开(公告)号：US09545443B2
公开(公告)日：2017-01-17
申请号：US14335129
申请日：2014-07-18
发明人： Kuo-Jang Kao , Andrew T. Huang
IPC分类号： A61K39/395 , A61K51/10 , C07K16/28 , C07K16/30 , G01N33/574 , A61K45/06 , C12Q1/68
CPC分类号： C07K16/28 , A61K39/39558 , A61K45/06 , A61K51/1018 , A61K51/1027 , A61K51/1057 , C07K16/303 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2319/21 , C12Q1/6886 , G01N33/57438 , G01N33/577 , G01N2333/47
摘要： The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.
摘要翻译： 本发明涉及治疗患者肝细胞癌的诊断方法和方法。 本发明还涉及PLVAP蛋白质的拮抗剂，例如特异性结合PLVAP蛋白质的抗体，以及包含PLVAP蛋白质拮抗剂的组合物和试剂盒。 本发明还涉及特异性结合PLVAP蛋白的人源化抗体。
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公开(公告)号：US20170000898A1
公开(公告)日：2017-01-05
申请号：US15270430
申请日：2016-09-20
发明人： Kuo-Jang Kao , Yun-Hsin Wang
IPC分类号： A61K47/48 , C07K14/745 , C07K16/30 , C07K16/18
CPC分类号： C07K14/745 , A61K47/65 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/92 , C07K2319/035 , C07K2319/33
摘要： The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.
摘要翻译： 本发明尤其提供包含与抗体缀合的凝血剂的缀合物，其中该抗体特异性结合哺乳动物PLVAP蛋白的细胞外结构域表位。 这些药物特异性靶向HCC肿瘤并治疗HCC。 本发明还提供使用这些缀合物的方法，例如通过施用本发明提供的缀合物或本发明提供的组合物如药物组合物来治疗HCC的方法。
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3.发明申请公开(公告)号：US20150017171A1
公开(公告)日：2015-01-15
申请号：US14336441
申请日：2014-07-21
发明人： Kuo-Jang Kao , Andrew T. Huang
IPC分类号： C07K16/18 , A61K39/395 , A61K45/06 , A61K47/48
CPC分类号： C07K16/18 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6861 , A61K2039/505 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/76
摘要： The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to polypeptide antagonists of PLVAP proteins, including humanized and chimeric antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising such polypeptide antagonists.
摘要翻译： 本发明涉及受试者的肝细胞癌的诊断方法和治疗方法。 本发明还涉及PLVAP蛋白的多肽拮抗剂，包括特异性结合PLVAP蛋白的人源化和嵌合抗体，以及包含这种多肽拮抗剂的组合物和试剂盒。
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4.发明申请公开(公告)号：US20140322131A1
公开(公告)日：2014-10-30
申请号：US14335129
申请日：2014-07-18
发明人： Kuo-Jang Kao , Andrew T. Huang
IPC分类号： C07K16/30 , G01N33/574 , A61K45/06 , A61K39/395 , A61K51/10
CPC分类号： C07K16/28 , A61K39/39558 , A61K45/06 , A61K51/1018 , A61K51/1027 , A61K51/1057 , C07K16/303 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2319/21 , C12Q1/6886 , G01N33/57438 , G01N33/577 , G01N2333/47
摘要： The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.
摘要翻译： 本发明涉及治疗患者肝细胞癌的诊断方法和方法。 本发明还涉及PLVAP蛋白质的拮抗剂，例如特异性结合PLVAP蛋白质的抗体，以及包含PLVAP蛋白质拮抗剂的组合物和试剂盒。 本发明还涉及特异性结合PLVAP蛋白的人源化抗体。
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公开(公告)号：US20180362614A1
公开(公告)日：2018-12-20
申请号：US16116644
申请日：2018-08-29
发明人： Kuo-Jang Kao , Yun-Hsin Wang
IPC分类号： C07K14/745
摘要： The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.
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公开(公告)号：US20170145092A1
公开(公告)日：2017-05-25
申请号：US15370711
申请日：2016-12-06
发明人： Kuo-Jang Kao , Andrew T. Huang
IPC分类号： C07K16/28 , G01N33/577 , G01N33/574 , C07K16/30 , A61K51/10
CPC分类号： C07K16/28 , A61K39/39558 , A61K45/06 , A61K51/1018 , A61K51/1027 , A61K51/1057 , C07K16/303 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2319/21 , C12Q1/6886 , G01N33/57438 , G01N33/577 , G01N2333/47
摘要： The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.
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公开(公告)号：US09493552B2
公开(公告)日：2016-11-15
申请号：US14539577
申请日：2014-11-12
发明人： Kuo-Jang Kao , Yun-Hsin Wang
IPC分类号： C07K14/745 , C07K16/28 , C07K16/18 , A61K47/48 , C07K16/30
CPC分类号： A61K47/48538 , A61K47/65 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K14/745 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/92 , C07K2319/035 , C07K2319/33
摘要： The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.
摘要翻译： 本发明尤其提供包含与抗体缀合的凝血剂的缀合物，其中该抗体特异性结合哺乳动物PLVAP蛋白的细胞外结构域表位。 这些药物特异性靶向HCC肿瘤并治疗HCC。 本发明还提供使用这些缀合物的方法，例如通过施用本发明提供的缀合物或本发明提供的组合物如药物组合物来治疗HCC的方法。
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8.发明授权公开(公告)号：US09394359B2
公开(公告)日：2016-07-19
申请号：US14336441
申请日：2014-07-21
发明人： Kuo-Jang Kao , Andrew T. Huang
CPC分类号： C07K16/18 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6861 , A61K2039/505 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/76
摘要： The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to polypeptide antagonists of PLVAP proteins, including humanized and chimeric antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising such polypeptide antagonists.
摘要翻译： 本发明涉及受试者的肝细胞癌的诊断方法和治疗方法。 本发明还涉及PLVAP蛋白的多肽拮抗剂，包括特异性结合PLVAP蛋白的人源化和嵌合抗体，以及包含这种多肽拮抗剂的组合物和试剂盒。
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公开(公告)号：US20150140021A1
公开(公告)日：2015-05-21
申请号：US14539577
申请日：2014-11-12
发明人： Kuo-Jang Kao , Yun-Hsin Wang
IPC分类号： C07K16/18 , C07K14/745
CPC分类号： A61K47/48538 , A61K47/65 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K14/745 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/92 , C07K2319/035 , C07K2319/33
摘要： The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.
摘要翻译： 本发明尤其提供包含与抗体缀合的凝血剂的缀合物，其中该抗体特异性结合哺乳动物PLVAP蛋白的细胞外结构域表位。 这些药物特异性靶向HCC肿瘤并治疗HCC。 本发明还提供使用这些缀合物的方法，例如通过施用本发明提供的缀合物或本发明提供的组合物如药物组合物来治疗HCC的方法。
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