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    L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo�2.2.1!heptane compound and the preparation of 2-azabicyclo�2.2.1! heptane compounds
    1.
    发明授权
    L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo�2.2.1!heptane compound and the preparation of 2-azabicyclo�2.2.1! heptane compounds 失效
    2-氮杂双环[2.2.1]庚烷化合物的（1R）非对映异构体的L-酒石酸盐和2-氮杂双环[2.2.1]庚烷化合物的制备

    公开(公告)号：US5831096A

    公开(公告)日：1998-11-03

    申请号：US873284

    申请日：1997-06-10

    申请人： Patrick Leon ,  Michael O'Brien ,  Denis Largeau ,  Matthew Powers ,  Ching Tsuei

    发明人： Patrick Leon ,  Michael O'Brien ,  Denis Largeau ,  Matthew Powers ,  Ching Tsuei

    IPC分类号： C07D491/18 ,  C07D209/02 ,  C07D209/52 ,  C07D491/12

    CPC分类号： C07D209/52 ,  C07D209/02 ,  Y02P20/55

    摘要： A method for the preparation of a compound of formula ##STR1## wherein R is hydrogen or, respectively, a group of formula ##STR2## R.sub.1 is alkyl; Ar is optionally substituted aryl; and R.sub.3' and R.sub.3" are hydrogen, alkyl or phenyl, or R.sub.3' and R.sub.3" taken together with the carbon atom to which they are attached form cycloalkyl, or salt thereof, comprising acid facilitated acetalizing or ketalizing of a compound of formula ##STR3## wherein R.sub.3' and R.sub.3" are as defined above, and R.sub.4' and R.sub.4" are alkoxy, or taken together with the carbon atom to which they are attached form carbonyl, with a compound of formula ##STR4## wherein * represents an R chirality; R, R.sub.1 and Ar are as defined above, or salt thereof in isopropanol.

    摘要翻译： 其中R为氢或分别为式（II）或（II）的基团的式的化合物的方法R1为烷基; Ar是任选取代的芳基; 并且R 3'和R 3“是氢，烷基或苯基，或者R 3'和R 3”与它们所连接的碳原子一起形成环烷基，或其盐，其包含酸容易地使下式化合物进行缩醛化或缩酮化 其中R 3'和R 3“如上定义，并且R 4'和R 4”是烷氧基，或者与它们所连接的碳原子一起形成羰基的化合物与式 ）其中*表示R手性; R，R 1和Ar如上所定义，或其盐在异丙醇中。