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公开(公告)号:US08236948B2
公开(公告)日:2012-08-07
申请号:US13356063
申请日:2012-01-23
IPC分类号: C07D285/24
CPC分类号: C07D417/04 , A61K31/5415 , A61K31/549 , A61K45/06 , C07D417/14 , C07D491/18 , C07D513/04
摘要: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and compounds used to synthesize the compounds of Formula I.
摘要翻译: 本发明涉及式I的5,6-二氢-1H-吡啶-2-酮化合物,其中X是N,A是用于合成式I化合物的化合物。
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公开(公告)号:US08129368B2
公开(公告)日:2012-03-06
申请号:US12576739
申请日:2009-10-09
申请人: Frank Ruebsam , Chinh V Tran , Douglas E. Murphy , Peggy A. Thompson , Peter Dragovich , Stephen E. Webber
发明人: Frank Ruebsam , Chinh V Tran , Douglas E. Murphy , Peggy A. Thompson , Peter Dragovich , Stephen E. Webber
IPC分类号: A61K31/5415
CPC分类号: C07D417/04 , C07D409/14
摘要: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of formula: wherein R is C1-C6 alkyl or (Aryl)CH2-,and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及下式的5,6-二氢-1H-吡啶-2-酮化合物:其中R是C 1 -C 6烷基或(芳基)CH 2 - ,并且含有这样的化合物的药物组合物可用于治疗肝炎感染 C病毒。
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公开(公告)号:US07939524B2
公开(公告)日:2011-05-10
申请号:US12061499
申请日:2008-04-02
申请人: Chinh V. Tran , Frank Ruebsam , Douglas E. Murphy , Peter Dragovich , Yuefen Zhou , Lijian Chen , David Kucera
发明人: Chinh V. Tran , Frank Ruebsam , Douglas E. Murphy , Peter Dragovich , Yuefen Zhou , Lijian Chen , David Kucera
IPC分类号: C07D413/04 , C07D491/04 , A61K31/549
CPC分类号: C07D417/04 , A61K31/5415 , A61K31/549 , A61K45/06 , C07D417/14 , C07D491/18 , C07D513/04
摘要: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及式I的5,6-二氢-1H-吡啶-2-酮化合物,其中X为N,A为含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号:US07834009B2
公开(公告)日:2010-11-16
申请号:US11845515
申请日:2007-08-27
申请人: David Ellis , Liansheng Li , Chinh V. Tran , Frank Ruebsam , Yuefen Zhou
发明人: David Ellis , Liansheng Li , Chinh V. Tran , Frank Ruebsam , Yuefen Zhou
IPC分类号: C07D417/04 , A61K31/549
CPC分类号: C07D417/04
摘要: The invention is directed to 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus: wherein R6 is X is N, Ring A is a 5- or 6-membered aryl, optionally substituted by 1-3 R8 moieties, n is 2, and R1-R6 and R8 are defined herein.
摘要翻译: 本发明涉及式I的4-羟基-5,6-二氢-1H-吡啶-2-酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物:其中R6是X是N, 环A是5-或6-元芳基,任选被1-3个R8部分取代,n是2,R1-R6和R8如本文所定义。
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公开(公告)号:US20100119481A1
公开(公告)日:2010-05-13
申请号:US12576739
申请日:2009-10-09
申请人: Frank Ruebsam , Chinh V. Tran , Douglas E. Murphy , Peggy A. Thompson , Peter Dragovich , Stephen E. Webber
发明人: Frank Ruebsam , Chinh V. Tran , Douglas E. Murphy , Peggy A. Thompson , Peter Dragovich , Stephen E. Webber
IPC分类号: A61K38/21 , C07D285/22 , A61K31/5415 , A61K31/7056 , A61P31/12 , A61P31/14
CPC分类号: C07D417/04 , C07D409/14
摘要: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
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公开(公告)号:US20090306057A1
公开(公告)日:2009-12-10
申请号:US12481391
申请日:2009-06-09
IPC分类号: C07D513/04 , A61K31/542
CPC分类号: C07D513/04 , C07D417/04
摘要: The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及[1,2,4]噻二嗪1,1-二氧化物化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号:US20120321590A1
公开(公告)日:2012-12-20
申请号:US13439959
申请日:2012-04-05
IPC分类号: A61K31/549 , C07D513/04 , A61P31/14 , A61P31/04 , A61P31/10 , A61P29/00 , A61P25/24 , A61P35/00 , A61P37/02 , A61K38/21 , A61K31/7056 , A61K38/19 , A61K31/7068 , C12N7/06 , C07D417/04
CPC分类号: C07D417/04 , C07D513/04
摘要: The invention is directed to amides of bicyclic amine compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及双环胺化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物的酰胺。
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公开(公告)号:US07582626B2
公开(公告)日:2009-09-01
申请号:US11955144
申请日:2007-12-12
申请人: Chinh V. Tran , Frank Ruebsam , Yuefen Zhou , Peter Dragovich , Alan X. Xiang
发明人: Chinh V. Tran , Frank Ruebsam , Yuefen Zhou , Peter Dragovich , Alan X. Xiang
IPC分类号: C07D417/04 , A61K31/549
CPC分类号: C07D417/04 , C07D417/14
摘要: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating hepatitis C virus infections: wherein Z is X is N or CR9; Y is —(CR4R5)n—; n is 2, 3, 4, or 5; and R1 through R9 are defined herein.
摘要翻译: 本发明涉及式I的5,6-二氢-1H-吡啶-2-酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物:其中Z是X是N或CR 9; Y是 - (CR4R5)n-; n为2,3,4或5; 并且R1至R9在本文中定义。
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公开(公告)号:US20080275032A1
公开(公告)日:2008-11-06
申请号:US11898334
申请日:2007-09-11
申请人: Yuefen Zhou , Liansheng Li , Stephen E. Webber , Peter Dragovich , Douglas E. Murphy , Chinh V. Tran , Jingjing Zhao , Frank Ruebsam
发明人: Yuefen Zhou , Liansheng Li , Stephen E. Webber , Peter Dragovich , Douglas E. Murphy , Chinh V. Tran , Jingjing Zhao , Frank Ruebsam
IPC分类号: A61K31/549 , C07D401/04 , C07D285/26 , A61K31/497 , A61P31/14
CPC分类号: C07D417/04 , C07D417/14
摘要: The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及哒嗪酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号:US20100034773A1
公开(公告)日:2010-02-11
申请号:US12061499
申请日:2008-04-02
申请人: Chinh V. Tran , Frank Ruebsam , Douglas E. Murphy , Peter Dragovich , Yuefen Zhou , Lijian Chen , David Kucera , Fritz Blatter , Martin Viertelhaus
发明人: Chinh V. Tran , Frank Ruebsam , Douglas E. Murphy , Peter Dragovich , Yuefen Zhou , Lijian Chen , David Kucera , Fritz Blatter , Martin Viertelhaus
IPC分类号: A61K38/21 , C12N7/04 , A61P31/12 , A61K31/542 , A61K31/5415 , C07D285/26 , C07D279/16
CPC分类号: C07D417/04 , A61K31/5415 , A61K31/549 , A61K45/06 , C07D417/14 , C07D491/18 , C07D513/04
摘要: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译: 本发明涉及5,6-二氢-1H-吡啶-2-酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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