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公开(公告)号:US20070010560A1
公开(公告)日:2007-01-11
申请号:US10564185
申请日:2004-06-15
申请人: Hans-Peter Buchstaller , Dirk Finsinger , Matthias Wiesner , Lars Burgdorf , Chriatiane Amendt , Matthias Grell , Chirstian Sirrenberg , Frank Zenke
发明人: Hans-Peter Buchstaller , Dirk Finsinger , Matthias Wiesner , Lars Burgdorf , Chriatiane Amendt , Matthias Grell , Chirstian Sirrenberg , Frank Zenke
IPC分类号: A61K31/4439 , A61K31/4184 , C07D403/02 , C07D235/28
CPC分类号: C07D401/12
摘要: The present invention relates to benzimidazole derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. Accordingly, the compound of Formula I or a pharmaceutically acceptable salt thereof is administered for the treatment of diseases mediated by one or more kinase pathways, preferably by the raf kinase pathway, especially cancers, [FORMULA]
摘要翻译: 本发明涉及式I的苯并咪唑衍生物,式I化合物作为一种或多种激酶抑制剂的用途,式I化合物用于制备药物组合物和治疗方法的用途,其包括给药 所述药物组合物对患者而言。 因此,式I化合物或其药学上可接受的盐被用于治疗由一种或多种激酶途径介导的疾病,优选地通过raf激酶途径,特别是癌症。[公式]