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公开(公告)号:US09512061B2
公开(公告)日:2016-12-06
申请号:US13720027
申请日:2012-12-19
申请人: Roland Bou Chedid , Alfred Oftring , Wolfgang Staffel , Markus Christian Biel , Johann-Peter Melder , Christian Gruenanger
发明人: Roland Bou Chedid , Alfred Oftring , Wolfgang Staffel , Markus Christian Biel , Johann-Peter Melder , Christian Gruenanger
IPC分类号: C07C227/08 , C07C229/08
CPC分类号: C07C227/08 , C07C229/08
摘要: Process for the preparation of racemic α-amino acids or of glycine, wherein the corresponding α-hydroxycarboxylic acid, selected from hydroxyacetic acid, lactic acid, malic acid, α-hydroxyglutamic acid, isocitric acid, tartronic acid and tartaric acid, or at least one salt of the corresponding α-hydroxycarboxylic acid is reacted in the presence of at least one heterogeneous catalyst which comprises at least one transition metal, in the presence of hydrogen with at least one nitrogen compound (c), where the nitrogen compound (c) is selected from primary and secondary amines and ammonia.
摘要翻译: 制备外消旋α-氨基酸或甘氨酸的方法,其中相应的α-羟基羧酸,选自羟基乙酸,乳酸,苹果酸,α-羟基谷氨酸,异柠檬酸,丙醇二酸和酒石酸,或至少 在至少一种氮化合物(c)的存在下,在至少一种包含至少一种过渡金属的非均相催化剂的存在下使相应的α-羟基羧酸的一种盐反应,其中氮化合物(c) 选自伯胺和仲胺和氨。
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公开(公告)号:US20130158294A1
公开(公告)日:2013-06-20
申请号:US13720027
申请日:2012-12-19
申请人: Roland BOU CHEDID , Alfred Oftring , Wolfgang Staffel , Markus Christian Biel , Johann-Peter Melder , Christian Gruenanger
发明人: Roland BOU CHEDID , Alfred Oftring , Wolfgang Staffel , Markus Christian Biel , Johann-Peter Melder , Christian Gruenanger
IPC分类号: C07C227/08
CPC分类号: C07C227/08 , C07C229/08
摘要: Process for the preparation of racemic α-amino acids or of glycine, wherein the corresponding α-hydroxycarboxylic acid, selected from hydroxyacetic acid, lactic acid, malic acid, α-hydroxyglutamic acid, isocitric acid, tartronic acid and tartaric acid, or at least one salt of the corresponding α-hydroxycarboxylic acid is reacted in the presence of at least one heterogeneous catalyst which comprises at least one transition metal, in the presence of hydrogen with at least one nitrogen compound (c), where the nitrogen compound (c) is selected from primary and secondary amines and ammonia.
摘要翻译: 制备外消旋α-氨基酸或甘氨酸的方法,其中相应的α-羟基羧酸,选自羟基乙酸,乳酸,苹果酸,α-羟基谷氨酸,异柠檬酸,丙醇三酸和酒石酸,或至少 在至少一种氮化合物(c)的存在下,在至少一种包含至少一种过渡金属的非均相催化剂的存在下,使相应的α-羟基羧酸的一种盐反应,其中氮化合物(c) 选自伯胺和仲胺和氨。
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