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    METHOD FOR MAKING OMEGA BROMOALKANOIC ACIDS AND ESTERS
    1.
    发明公开
    METHOD FOR MAKING OMEGA BROMOALKANOIC ACIDS AND ESTERS 审中-公开

    公开(公告)号：US20240140898A1

    公开(公告)日：2024-05-02

    申请号：US18004359

    申请日：2021-07-09

    申请人： ARKEMA FRANCE

    发明人： Jean-François DEVAUX ,  Cyrille LE TOULLEC ,  Alain CAMBON

    IPC分类号： C07C51/363 ,  C07C51/42 ,  C07C227/08 ,  C08G69/08

    CPC分类号： C07C51/363 ,  C07C51/42 ,  C07C227/08 ,  C08G69/08

    摘要： The invention relates to a process for the continuous synthesis of a compound of formula (II) Br—(CH2)n+2—COOR, comprising a stage consisting of:



    (a) the hydrobromination of a compound of formula (I) CH2═CH—(CH2)n—COOR:

    where, in the formulae (I) and (II), n is an integer of between 7 and 9, and R is chosen from H or a linear or branched alkyl radical comprising from 1 to 10 carbon atoms, in particular methyl, ethyl, isopropyl or propyl,
    with HBr in the presence of a radical initiator and of at least one solvent;

    said process being characterized in that the reaction is carried out in the absence of benzene and of toluene and in that, in stage (a), the HBr is injected into the reaction mixture in the gaseous form and in stoichiometric excess.

    Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
    3.
    发明授权
    Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis 有权

    公开(公告)号：US10308588B2

    公开(公告)日：2019-06-04

    申请号：US15536295

    申请日：2015-12-15

    申请人： ORGANOFUEL SWEDEN AB

    发明人： Armando Córdova ,  Carlos Palo-Nieto ,  Samson Afewerki

    IPC分类号： C07D307/34 ,  C07C209/28 ,  C07D317/58 ,  C07C41/18 ,  C07C41/26 ,  C07C45/38 ,  C07C213/02 ,  C07C227/08 ,  C07C231/02 ,  C07D307/52 ,  B01J23/44 ,  B01J31/02 ,  B01J35/00 ,  B01J35/04

    摘要： A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

    Process for the production of carnitine from β-lactones
    10.
    发明授权
    Process for the production of carnitine from β-lactones 有权
    从β-内酯生产肉碱的方法

    公开(公告)号：US09394238B2

    公开(公告)日：2016-07-19

    申请号：US14521700

    申请日：2014-10-23

    申请人： Lonza Ltd.

    发明人： Paul Hanselmann ,  Ellen Klegraf

    IPC分类号： C07C229/12 ,  C07C229/22 ,  C07C227/08 ,  C07C227/40 ,  C07C227/42 ,  C07D305/12

    CPC分类号： C07C229/22 ,  C07C227/08 ,  C07C227/40 ,  C07C227/42 ,  C07D305/12

    摘要： The invention relates to a method for the production of L-carnitine, wherein a β-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the β-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.

    摘要翻译： 本发明涉及生产L-肉毒碱的方法，其中将4-（卤代甲基）氧杂环丁烷-2-酮的一种内酯与三甲胺（TMA）一起转化为肉碱，其中， 内酯在与三甲胺接触之前不经历碱性水解步骤。 本发明还涉及具有独特杂质分布的肉碱。