公开(公告)号：US20170065199A1

公开(公告)日：2017-03-09

申请号：US14843996

申请日：2015-09-03

Applicant: Christian Meisel

Inventor： Christian Meisel

IPC: A61B5/0476 ,  A61B5/00 ,  A61B5/16 ,  A61B5/04

CPC classification number: A61B5/0476 ,  A61B5/04012 ,  A61B5/165 ,  A61B5/4094 ,  A61B5/4815 ,  A61B5/4818 ,  A61B5/4848 ,  A61B5/6803

Abstract: The present invention is directed to a method of continuously monitoring neuronal synchronization in a subject comprising (a) determining a deviation in mean synchronization (R) from a predetermined value at rest, wherein the pre-determined value of R is 1, and the variability of synchronization H; and (b) repeating step (a) one or more times to continuously monitor synchronization R and its variability H in a subject. The invention also features methods of determining and monitoring the degree of brain excitability. The invention furthermore features methods of determining or monitoring the degree of sleep deprivation in a subject, methods of identifying subjects that are susceptible to a sleep disorder and methods of diagnosing a sleep disorder in a subject.

Abstract translation: 本发明涉及一种连续监测受试者中的神经元同步的方法，包括：（a）从休息的预定值确定平均同步（R）的偏差，其中R的预定值为1，并且变异性 的同步H; 和（b）重复步骤（a）一次或多次以连续监测对象中的同步R及其变异性H. 本发明还具有确定和监测脑兴奋性程度的方法。 本发明还具有确定或监测受试者睡眠剥夺程度的方法，识别对睡眠障碍敏感的受试者的方法和诊断受试者睡眠障碍的方法。

公开(公告)号：US08673934B2

公开(公告)日：2014-03-18

申请号：US10506598

申请日：2003-03-05

Applicant: Andreas Meisel ,  Konstantin Prass ,  Christian Meisel ,  Elke Halle ,  Ulrich Dirnagl ,  Hans Dieter Volk

Inventor： Andreas Meisel ,  Konstantin Prass ,  Christian Meisel ,  Elke Halle ,  Ulrich Dirnagl ,  Hans Dieter Volk

IPC: A61K31/4709 ,  A61K45/06

CPC classification number: A61K45/06 ,  A61K31/4709 ,  A61K38/217 ,  C12N2710/24232 ,  A61K2300/00

Abstract: The invention refers to agents for the preventive therapy after acute stroke, in particular having the aim to prevent infections after stroke. The agents inventively employed in pharmaceutical preparations are anti-infective agents and/or immunomodulating agents, e.g. cytokines and/or inhibitors of the SNS.

Abstract translation: 本发明涉及用于急性中风后预防性治疗的药剂，特别是旨在预防中风后的感染。 创造性地用于药物制剂的药剂是抗感染剂和/或免疫调节剂，例如， SNS的细胞因子和/或抑制剂。

公开(公告)号：US20050234089A1

公开(公告)日：2005-10-20

申请号：US10506598

申请日：2003-03-05

Applicant: Andreas Meisel ,  Konstantin Prass ,  Christian Meisel ,  Elke Halle ,  Ulrich Dirnagl ,  Hans Volk

Inventor： Andreas Meisel ,  Konstantin Prass ,  Christian Meisel ,  Elke Halle ,  Ulrich Dirnagl ,  Hans Volk

IPC: A61K31/00 ,  A61K31/198 ,  A61K31/407 ,  A61K31/43 ,  A61K31/431 ,  A61K31/437 ,  A61K31/4709 ,  A61K38/19 ,  A61K38/21 ,  A61K45/00 ,  A61K45/06 ,  A61P9/10 ,  A61P31/00 ,  A61K38/14 ,  A61K31/4745 ,  A61K31/7048 ,  A61K31/704 ,  A61K31/397

CPC classification number: A61K45/06 ,  A61K31/4709 ,  A61K38/217 ,  C12N2710/24232 ,  A61K2300/00

Abstract: The invention refers to agents for the preventive therapy after acute stroke, in particular having the aim to prevent infections after stroke. The agents inventively employed in pharmaceutical preparations are anti-infective agents and/or immunomodulating agents, e.g. cytokines and/or inhibitors of the SNS.

Abstract translation: 本发明涉及用于急性中风后预防性治疗的药剂，特别是旨在预防中风后的感染。 创造性地用于药物制剂的药剂是抗感染剂和/或免疫调节剂，例如， SNS的细胞因子和/或抑制剂。