公开(公告)号：US20130195884A1

公开(公告)日：2013-08-01

申请号：US13519955

申请日：2010-12-30

申请人： Michael Boutros ,  Henning Walczak ,  Sandra Steinbrink ,  Christina Falschlehner

发明人： Michael Boutros ,  Henning Walczak ,  Sandra Steinbrink ,  Christina Falschlehner

IPC分类号： A61K38/17 ,  A61K38/48 ,  A61K38/53 ,  G01N33/68 ,  A61K45/06 ,  A61K39/395 ,  C12Q1/68 ,  A61K38/46 ,  A61K38/50

CPC分类号： A61K38/1709 ,  A61K38/177 ,  A61K38/465 ,  A61K38/4813 ,  A61K38/50 ,  A61K38/53 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/4747 ,  C07K14/70575 ,  C12Q1/6876 ,  G01N33/6863

摘要： The present invention relates to an agent for use as a modulator of apoptosis-factor-associated cell death, apoptosis, cell survival, migration and/or proliferation, a method of diagnosing or monitoring apoptosis-factor-associated conditions or disorders as well as a method of identifying a modulator of apoptosis-factor-associated cell death, apoptosis, cell survival, migration and/or proliferation. Preferably, the invention relates to TRAIL-induced cell death and/or TRAIL-induced apoptosis. Preferably the agents are used to stimulate and/or enable TRAIL-induced cell death or to inhibit TRAIL-induced cell death. The preferable use of the diagnostic tools is to diagnose sensitivity or resistance to TRAIL-induced cell death or induction of sensitivity or resistance to TRAIL-induced cell death by an agent.

摘要翻译： 本发明涉及用作凋亡因子相关细胞死亡，凋亡，细胞存活，迁移和/或增殖的调节剂的试剂，诊断或监测凋亡因子相关病症或病症的方法以及 识别凋亡因子相关细胞死亡，凋亡，细胞存活，迁移和/或增殖的调节剂的方法。 优选地，本发明涉及TRAIL诱导的细胞死亡和/或TRAIL诱导的凋亡。 优选地，所述试剂用于刺激和/或使TRAIL诱导的细胞死亡或抑制TRAIL诱导的细胞死亡。 诊断工具的优选使用是诊断TRAIL诱导的细胞死亡的敏感性或抗性或诱导TRAIL诱导的细胞死亡的敏感性或抗性。