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公开(公告)号：US08420642B2
公开(公告)日：2013-04-16
申请号：US12682055
申请日：2008-08-13
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/444 , A61K31/4545 , C07D417/12 , C07D401/12 , C07D417/14 , A61P3/10 , A61P13/12
CPC分类号： C07D417/12 , C07D213/74 , C07D401/12 , C07D401/14 , C07D417/14
摘要： Novel heterocyclic compounds of the formula I in which R1, R2, R3, R4 and D have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
摘要翻译： 其中R1，R2，R3，R4和D具有权利要求1所述含义的式I的新型杂环化合物是葡糖激酶的活化剂，可用于预防和/或治疗糖尿病1型和2型，肥胖症， 神经病和/或肾病。
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2.发明申请PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权吡咯烷酮衍生物胰岛素分泌刺激物，用于获得它们的方法及其用于治疗糖尿病的方法公开(公告)号：US20130023537A1
公开(公告)日：2013-01-24
申请号：US13614702
申请日：2012-09-13
IPC分类号： A61K31/4985 , A61P9/12 , A61P3/10 , A61P3/04 , C07D471/04 , A61P9/10
CPC分类号： C07D471/04
摘要： The present invention relates to pyridopyrazinone derivatives of formula (I), wherein X, Y, Z1 W, A and R1 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyridopyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的吡啶并吡唑酮衍生物，其中X，Y，Z 1 W，A和R 1如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些吡哆吡嗪酮衍生物用于预防和/或治疗相关的糖尿病和病症的制备和用途。
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3.发明授权Use of AMPK-activating imidazole derivatives, preparation process therefor and pharmaceutical compositions comprising them 有权使用AMPK活化的咪唑衍生物，其制备方法和包含它们的药物组合物公开(公告)号：US08329738B2
公开(公告)日：2012-12-11
申请号：US12373310
申请日：2007-06-12
CPC分类号： C07D233/90
摘要： The invention relates to the use of imidazole derivatives of the formula (1): in which A, R′1, R′2 and R′3 are as defined in the description, as AMPK activators. The invention also relates to processes for the preparation of the said compounds, to their uses for the preparation of medicaments for the treatment of insulin resistance, diabetes and related pathologies, and also obesity, and to the pharmaceutical compositions comprising them.Certain compounds of the formula (1) are novel and, in this respect, also form part of the invention.
摘要翻译： 本发明涉及式（1）的咪唑衍生物的用途：其中A，R'1，R'2和R'3如说明书中所定义，作为AMPK活化剂。 本发明还涉及制备所述化合物的方法，其制备用于治疗胰岛素抵抗的药物，糖尿病和相关病症以及肥胖症的用途，以及包含它们的药物组合物。 某些式（1）化合物是新颖的，在这方面也是本发明的一部分。
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4.发明申请Arylpyrazinone derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes 有权芳基吡嗪酮衍生物胰岛素分泌刺激剂，获得它们的方法及其用于治疗糖尿病的用途公开(公告)号：US20110046159A1
公开(公告)日：2011-02-24
申请号：US12990098
申请日：2009-03-31
IPC分类号： A61K31/497 , C07D241/18 , C07D401/10 , A61K31/4965 , A61P3/10
CPC分类号： C07D241/08 , C07D241/18 , C07D241/38 , C07D401/04 , C07D403/04 , C07D405/04
摘要： The present invention relates to arylpyrazinone derivatives of formula (I), wherein R1, R2, R3 and A are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 本发明涉及式（I）的芳基吡嗪酮衍生物，其中R1，R2，R3和A如权利要求1中所定义，作为胰岛素分泌刺激剂。 本发明还涉及这些吡嗪酮衍生物用于预防和/或治疗相关的糖尿病和病理学的制备和用途。
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5.发明申请THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS 有权作为AMP活化蛋白激酶（AMPK）激活剂的三烯酰基衍生物公开(公告)号：US20110034505A1
公开(公告)日：2011-02-10
申请号：US12937147
申请日：2009-03-17
IPC分类号： A61K31/4365 , C07D495/04 , A61P3/04 , A61P3/10 , A61P29/00 , A61P35/00 , A61P9/00
CPC分类号： C07D495/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2和R 3如权利要求1中所定义，包括其药物组合物及其用于治疗和/或预防由AMP激动剂调节的疾病和障碍。 本发明还涉及中间体和式（I）化合物的制备方法。
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公开(公告)号：US20100331346A1
公开(公告)日：2010-12-30
申请号：US12864348
申请日：2008-12-23
申请人： Stefan Bender , Lars Thore Burgdorf , Ulrich Emde , Norbert Beier , Johannes Gleitz , Christine Charon
发明人： Stefan Bender , Lars Thore Burgdorf , Ulrich Emde , Norbert Beier , Johannes Gleitz , Christine Charon
IPC分类号： A61K31/497 , C07D401/12 , C07D409/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D401/14 , C07D403/12 , C07D413/12 , A61K31/4439 , A61K31/427 , A61K31/444 , A61K31/506 , A61K31/4155 , A61K31/4184 , A61K31/422 , A61P13/12 , A61P25/00 , A61P3/10 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Novel heterocyclic compounds of the formula I in which R1, R2, R2′, R2″, R3, R4, R5, R6, R7 and R8 have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
摘要翻译： 其中R1，R2，R2'，R2“，R3，R4，R5，R6，R7和R8具有权利要求1所述含义的式I的新型杂环化合物是葡糖激酶的活化剂，可用于预防和 /或治疗1型和2型糖尿病，肥胖，神经病和/或肾病。
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7.发明授权Substituted pyrazin-2-ones and substituted 5,6,7,8-tetrahydroquinoxalin-2-ones and methods of use thereof 有权取代的吡嗪-2-酮和取代的5,6,7,8-四氢喹喔啉-2-酮及其使用方法公开(公告)号：US08815859B2
公开(公告)日：2014-08-26
申请号：US12990098
申请日：2009-03-31
IPC分类号： A61K31/4965 , A61K31/498 , C07D241/18 , C07D241/44
CPC分类号： C07D241/08 , C07D241/18 , C07D241/38 , C07D401/04 , C07D403/04 , C07D405/04
摘要： Arylpyrazinone derivatives of formula (I), as insulin secretion stimulators, the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
摘要翻译： 式（I）的吡咯烷酮衍生物作为胰岛素分泌刺激剂，这些吡嗪酮衍生物用于预防和/或治疗糖尿病和病理相关的制备和用途。
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公开(公告)号：US20100216794A1
公开(公告)日：2010-08-26
申请号：US12682055
申请日：2008-08-13
IPC分类号： A61K31/5377 , C07D417/12 , A61K31/4439 , A61P3/10 , A61P3/04 , A61P13/12 , C07D401/12 , C07D417/14 , A61K31/444 , A61K31/4545
CPC分类号： C07D417/12 , C07D213/74 , C07D401/12 , C07D401/14 , C07D417/14
摘要： Novel heterocyclic compounds of the formula I in which R1, R2, R3, R4 and D have the meanings indicated in claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
摘要翻译： 其中R1，R2，R3，R4和D具有权利要求1所述含义的式I的新型杂环化合物是葡糖激酶的活化剂，可用于预防和/或治疗糖尿病1型和2型，肥胖症， 神经病和/或肾病。
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9.发明申请N-(PYRAZOLE-3-YL)-BENZAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS 有权N-（吡咯-3-基） - 苯甲酰胺衍生物作为GLUCOKINASE激活剂公开(公告)号：US20100210690A1
公开(公告)日：2010-08-19
申请号：US12682049
申请日：2008-09-09
申请人： Lars Thore Burgdorf , Norbert Beier , Johannes Gleitz , Ulrich Emde , Christine Charon , Denis Carniato
发明人： Lars Thore Burgdorf , Norbert Beier , Johannes Gleitz , Ulrich Emde , Christine Charon , Denis Carniato
IPC分类号： A61K31/4439 , C07D401/06 , C07D231/40 , A61K31/415 , A61P3/04 , A61P3/10 , A61P13/12 , A61P25/00
CPC分类号： C07D401/06 , C07D231/40 , C07D409/12 , C07D409/14
摘要： Novel heterocyclic compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, Alk and D have the meanings indicated in claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
摘要翻译： 其中R1，R2，R3，R4，R5，R6，R7，Alk和D具有权利要求1所述含义的式I的新型杂环化合物是葡糖激酶的活化剂，可用于预防和/或治疗 1型和2型糖尿病，肥胖，神经病和/或肾病。
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10.发明申请USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权AMPK活化咪唑衍生物的使用，其制备方法及包含它们的药物组合物公开(公告)号：US20090253764A1
公开(公告)日：2009-10-08
申请号：US12373310
申请日：2007-06-12
IPC分类号： A61K31/4178 , A61K31/4164 , C07D233/22 , A61P3/04 , A61P3/10 , A61P9/00
CPC分类号： C07D233/90
摘要： The invention relates to the use of imidazole derivatives of the formula (1): in which A, R′1, R′2 and R′3 are as defined in the description, as AMPK activators.The invention also relates to processes for the preparation of the said compounds, to their uses for the preparation of medicaments for the treatment of insulin resistance, diabetes and related pathologies, and also obesity, and to the pharmaceutical compositions comprising them.Certain compounds of the formula (1) are novel and, in this respect, also form part of the invention.
摘要翻译： 本发明涉及式（1）的咪唑衍生物的用途：其中A，R'1，R'2和R'3如说明书中所定义，作为AMPK活化剂。 本发明还涉及制备所述化合物的方法，其制备用于治疗胰岛素抵抗的药物，糖尿病和相关病症以及肥胖症的用途，以及包含它们的药物组合物。 某些式（1）化合物是新颖的，在这方面也是本发明的一部分。
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