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公开(公告)号：US08679488B2
公开(公告)日：2014-03-25
申请号：US13386451
申请日：2010-08-02
Applicant: Manuela Kaspar , Christoph Schliemann , Dario Neri
Inventor： Manuela Kaspar , Christoph Schliemann , Dario Neri
IPC: A61K39/395 , A61K39/00
CPC classification number: A61K39/39558 , C07K16/18 , C07K16/3061 , C07K2317/21 , C07K2317/528 , C07K2317/622 , C07K2317/64 , G01N33/57426
Abstract: Antibodies which bind an antigen of the bone marrow neovasculature in leukaemia patients, for use in treatment and diagnosis of leukaemia, in particular the treatment and diagnosis of acute myeloid leukaemia (AML).
Abstract translation: 在白血病患者中结合骨髓新血管系统抗原的抗体，用于治疗和诊断白血病，特别是急性骨髓性白血病（AML）的治疗和诊断。
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Patent Agency Ranking
2.发明授权Combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart 有权抗EDb纤连蛋白抗体-IL-2融合蛋白与结合B细胞，B细胞祖细胞和/或其癌性对应物的分子的组合公开(公告)号：US08796426B2
公开(公告)日：2014-08-05
申请号：US12270174
申请日：2008-11-13
Applicant: Dario Neri , Hans Dietrich Menssen , Andreas Menrad , Christoph Schliemann
Inventor： Dario Neri , Hans Dietrich Menssen , Andreas Menrad , Christoph Schliemann
CPC classification number: A61K38/2013 , A61K39/3955 , A61K39/39558 , A61K39/44 , A61K45/06 , A61K47/6813 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K2039/505 , C07K14/55 , C07K16/18 , C07K16/2887 , C07K16/3061 , C07K16/46 , A61K2300/00
Abstract: The present invention relates to a combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart and uses thereof.
Abstract translation: 本发明涉及抗EDb纤连蛋白抗体-IL-2融合蛋白和结合B细胞，B细胞祖细胞和/或其癌性对应物的分子及其用途的组合。
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公开(公告)号：US20120121506A1
公开(公告)日：2012-05-17
申请号：US13386451
申请日：2010-08-02
Applicant: Manuela Kaspar , Christoph Schliemann , Dario Neri
Inventor： Manuela Kaspar , Christoph Schliemann , Dario Neri
IPC: A61K39/395 , A61P35/02 , A61K51/10 , G01N33/574
CPC classification number: A61K39/39558 , C07K16/18 , C07K16/3061 , C07K2317/21 , C07K2317/528 , C07K2317/622 , C07K2317/64 , G01N33/57426
Abstract: Antibodies which bind an antigen of the bone marrow neovasculature in leukaemia patients, for use in treatment and diagnosis of leukaemia, in particular the treatment and diagnosis of acute myeloid leukaemia (AML).
Abstract translation: 在白血病患者中结合骨髓新血管系统抗原的抗体，用于治疗和诊断白血病，特别是急性骨髓性白血病（AML）的治疗和诊断。
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公开(公告)号：US20110318302A1
公开(公告)日：2011-12-29
申请号：US13140150
申请日：2009-12-23
Applicant: Kathrin Schwager , Katharina Frey , Christoph Schliemann , Neri Dario
Inventor： Kathrin Schwager , Katharina Frey , Christoph Schliemann , Neri Dario
IPC: A61K39/395 , A61P35/00
CPC classification number: A61K47/6843 , A61K47/6813
Abstract: The invention relates to the treatment of cancer, e.g. kidney cancer, using chemotherapeutic agents and immunocytokines, in particular immunocytokines which bind to the Extra Domain-A (ED-A) isoform of fibronectin.
Abstract translation: 本发明涉及癌症的治疗，例如， 肾癌，使用化学治疗剂和免疫细胞因子，特别是结合纤连蛋白的Extra-A（ED-A）同种型的免疫细胞因子。
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5.发明申请COMBINATION OF AN ANTI-EDB FIBRONECTIN ANTIBODY-IL-2 FUSION PROTEIN, AND A MOLECULE BINDING TO B CELLS, B CELL PROGENITORS AND /OR THEIR CANCEROUS COUNTERPART 审中-公开抗EDB FIBRONECTIN抗体-IL-2融合蛋白的组合，以及与B细胞的分子结合，B细胞前体和/或其CANCEROUS COUNTERPART公开(公告)号：US20100310454A1
公开(公告)日：2010-12-09
申请号：US12863417
申请日：2008-11-08
Applicant: Dario Neri , Hans Dietrich Menssen , Andreas Menrad , Christoph Schliemann
Inventor： Dario Neri , Hans Dietrich Menssen , Andreas Menrad , Christoph Schliemann
IPC: A61K51/10 , A61K38/20 , A61K39/395 , A61P35/00 , A61P37/00
CPC classification number: A61K38/2013 , A61K39/3955 , A61K39/39558 , A61K39/44 , A61K45/06 , A61K47/6813 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K2039/505 , C07K14/55 , C07K16/18 , C07K16/2887 , C07K16/3061 , C07K16/46 , A61K2300/00
Abstract: The present invention relates to a combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart and uses thereof.
Abstract translation: 本发明涉及抗EDb纤连蛋白抗体-IL-2融合蛋白和与B细胞，B细胞祖细胞和/或其癌性对应物结合的分子及其用途的组合。
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6.发明申请COMBINATION OF AN ANTI-EDB FIBRONECTIN ANTIBODY-IL-2 FUSION PROTEIN, AND A MOLECULE BINDING TO B CELLS, B CELL PROGENITORS AND/OR THEIR CANCEROUS COUNTERPART 有权抗EDB FIBRONECTIN抗体-IL-2融合蛋白的组合，以及与B细胞的分子结合，B细胞前体和/或其CANCEROUS COUNTERPART公开(公告)号：US20090202473A1
公开(公告)日：2009-08-13
申请号：US12270174
申请日：2008-11-13
Applicant: Dario NERI , Hans Dietrich Menssen , Andreas Menrad , Christoph Schliemann
Inventor： Dario NERI , Hans Dietrich Menssen , Andreas Menrad , Christoph Schliemann
CPC classification number: A61K38/2013 , A61K39/3955 , A61K39/39558 , A61K39/44 , A61K45/06 , A61K47/6813 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K2039/505 , C07K14/55 , C07K16/18 , C07K16/2887 , C07K16/3061 , C07K16/46 , A61K2300/00
Abstract: The present invention relates to a combination of an anti-EDb fibronectin antibody-IL-2 fusion protein, and a molecule binding to B cells, B cell progenitors and/or their cancerous counterpart and uses thereof.
Abstract translation: 本发明涉及抗EDb纤连蛋白抗体-IL-2融合蛋白和与B细胞，B细胞祖细胞和/或其癌性对应物结合的分子及其用途的组合。
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