Water soluble acrylic membrane-polymer protein amphiphilic complex and application to diagnosis methods
    2.
    发明授权
    Water soluble acrylic membrane-polymer protein amphiphilic complex and application to diagnosis methods 有权
    水溶性丙烯酸聚合物蛋白质两亲性复合物及应用于诊断方法

    公开(公告)号:US06492501B1

    公开(公告)日:2002-12-10

    申请号:US09331036

    申请日:1999-11-05

    IPC分类号: C07K1708

    摘要: The invention concerns a water soluble vinyl membrane-polymer protein amphiphilic complex, characterised in that said vinyl polymer corresponds to formula (I) in which: R1 is a group: COO⊖ M+ M+ being an alkaline cation, COOR7, R7 being a sugar radical; polyoxyalkylene, polyoxyethylene; N-pyrrolidonyl; phenyl sulphonate; CONR8R9, R8 and R9 identical or different being hydrogen atom, a sugar radical, polyoxyalkylene, in particular polyoxyethylene, a zwitterion radical; R4, R5, R6 identical or different are hydrogen atom, or methyl radical; R2 is a COOR12 or CONR13R14 radical, R12 being a linear or branched alkyl or alkylene radical; R13, R14 identical or different have one of the meanings of R12, and moreover one of the two can correspond to hydrogen atom; R3 is a COOR15 or CONR16R17 radical; R15 being a (C1-C5) alkyl radical; R16, R17 having one if the meanings of R15 and moreover one of the two can correspond to hydrogen atom; x, y, z correspond to the respective percentages of units. The complex is applicable for producing reagent and diagnosis kits.

    摘要翻译: 本发明涉及一种水溶性乙烯基膜 - 聚合物蛋白质两亲性复合物,其特征在于所述乙烯基聚合物对应于式(I),其中:R 1为基团:COO m M + M +为碱性阳离子,COOR 7,R 7为糖基 ; 聚氧化烯,聚氧乙烯; N-吡咯烷酮; 苯基磺酸盐; CONR8R9,R8和R9相同或不同,为氢原子,糖基,聚氧化烯,特别是聚氧乙烯,两性离子基; R4,R5,R6相同或不同,是氢原子或甲基; R2是COOR12或CONR13R14基团,R12是直链或支链烷基或亚烷基; R13,R14相同或不同,具有R12的含义之一,而且两者之一可以对应于氢原子; R3是COOR15或CONR16R17基团; R15为(C1-C5)烷基; R16,R17如果R15的含义和二者之一可以对应于氢原子; x,y,z对应于单位的相应百分比。 该复合物适用于生产试剂和诊断试剂盒。