公开(公告)号：US20090291432A1

公开(公告)日：2009-11-26

申请号：US11628397

申请日：2005-06-01

申请人： Charles Phillip Morris ,  Angela Van Daal ,  Christopher Dean Swagell ,  Bruce Robert Lawford ,  Ross McDonald Young

发明人： Charles Phillip Morris ,  Angela Van Daal ,  Christopher Dean Swagell ,  Bruce Robert Lawford ,  Ross McDonald Young

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N2800/28 ,  G01N2800/30

摘要： The present invention relates to a method for profiling an individual or group of individuals with respect to a neurological, psychiatric or psychological condition, phenotype or state, including a sub-threshold neurological, psychiatric or psychological condition, phenotype or state. More particularly, the present invention identifies a genetic profile associated with the 957C>T polymorphysm within the dopamine receptor D2 (DRD2), indicating a predisposition to schizophrenia and other neurological diseases.

摘要翻译： 本发明涉及一种关于神经，精神或心理状况，表型或状态（包括亚阈值神经，精神或心理状况，表型或状态）的个体或个体个体的分析方法。 更具体地，本发明鉴定与多巴胺受体D2（DRD2）内的957C> T多态性相关的遗传谱，表明精神分裂症和其他神经疾病的倾向。

公开(公告)号：US20090075827A1

公开(公告)日：2009-03-19

申请号：US12016438

申请日：2008-01-18

申请人： Ross Young ,  Bruce Lawford ,  C. Phillip Morris ,  Joanne Voisey ,  Ian Hughes ,  Christopher Dean Swagell

发明人： Ross Young ,  Bruce Lawford ,  C. Phillip Morris ,  Joanne Voisey ,  Ian Hughes ,  Christopher Dean Swagell

IPC分类号： C40B30/00 ,  C40B40/06 ,  C12Q1/68 ,  C12Q1/02 ,  G01N33/566

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention relates generally to a method and agents for profiling or stratifying an individual or group of individuals with respect to a neurological, psychiatric or psychological condition, phenotype or state, including a sub-threshold neurological, psychiatric or psychological condition, phenotype or state. More particularly, the present invention utilizes genetic means to profile or stratify individuals with respect to a neurological, psychiatric or psychological condition, phenotype or state. The present invention enables the identification of individuals at risk of these disorders thus affording the opportunity for early intervention. In addition, the subject invention allows the prediction of drug or other treatment response and adverse reactions.

摘要翻译： 本发明一般涉及关于神经，精神或心理状况，表型或状态，包括亚阈值神经，精神或心理状况，表型或状态的个体或个体个体的分类或分层的方法和试剂 。 更具体地说，本发明利用遗传方法对个体进行轮廓或分层，这些个体对于神经，精神或心理状况，表型或状态。 本发明能够识别处于这些疾病风险中的个体，从而提供早期干预的机会。 此外，本发明允许预测药物或其他治疗反应和不良反应。