公开(公告)号：US20090075827A1

公开(公告)日：2009-03-19

申请号：US12016438

申请日：2008-01-18

申请人： Ross Young ,  Bruce Lawford ,  C. Phillip Morris ,  Joanne Voisey ,  Ian Hughes ,  Christopher Dean Swagell

发明人： Ross Young ,  Bruce Lawford ,  C. Phillip Morris ,  Joanne Voisey ,  Ian Hughes ,  Christopher Dean Swagell

IPC分类号： C40B30/00 ,  C40B40/06 ,  C12Q1/68 ,  C12Q1/02 ,  G01N33/566

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention relates generally to a method and agents for profiling or stratifying an individual or group of individuals with respect to a neurological, psychiatric or psychological condition, phenotype or state, including a sub-threshold neurological, psychiatric or psychological condition, phenotype or state. More particularly, the present invention utilizes genetic means to profile or stratify individuals with respect to a neurological, psychiatric or psychological condition, phenotype or state. The present invention enables the identification of individuals at risk of these disorders thus affording the opportunity for early intervention. In addition, the subject invention allows the prediction of drug or other treatment response and adverse reactions.

摘要翻译： 本发明一般涉及关于神经，精神或心理状况，表型或状态，包括亚阈值神经，精神或心理状况，表型或状态的个体或个体个体的分类或分层的方法和试剂 。 更具体地说，本发明利用遗传方法对个体进行轮廓或分层，这些个体对于神经，精神或心理状况，表型或状态。 本发明能够识别处于这些疾病风险中的个体，从而提供早期干预的机会。 此外，本发明允许预测药物或其他治疗反应和不良反应。

公开(公告)号：US07519592B2

公开(公告)日：2009-04-14

申请号：US10940304

申请日：2004-09-14

申请人： Ian Hughes ,  Nicholas James Midgley

发明人： Ian Hughes ,  Nicholas James Midgley

IPC分类号： G06F7/10 ,  G06F17/00

CPC分类号： G06F17/30864 ,  Y10S707/99933 ,  Y10S707/99936

摘要： System, method and computer program for initiating a search at a server computer. A data base including a URL of the server computer is stored at a client computer. Information entered by a user into the client computer is received. From the information, a search term and the URL of the server computer are identified. Then, an HTTP search request which includes the URL of the server computer and the search term is generated. Then, the HTTP search request is sent to the server computer. The identifying of the URL of the server computer comprises searching the data base for a character string contained in the information that matches the URL of the server computer. The identifying of the search term comprises identifying a portion of the information appended to the URL of the server. The identifying of the search term also comprises omitting from the portion one or more symbols adjacent to the search term which are inconsistent with a search request using HTTP. The generating of the HTTP search request which combines the URL of the server computer and the search term comprises inserting adjacent to the search term one or more symbols consistent with a search request using HTTP.

摘要翻译： 用于在服务器计算机上发起搜索的系统，方法和计算机程序。 包含服务器计算机的URL的数据库存储在客户端计算机中。 接收用户进入客户端计算机的信息。 从信息中，识别搜索项和服务器计算机的URL。 然后，生成包括服务器计算机的URL和搜索项的HTTP搜索请求。 然后，将HTTP搜索请求发送到服务器计算机。 服务器计算机的URL的识别包括在数据库中搜索包含在与服务器计算机的URL匹配的信息中的字符串。 搜索项的识别包括识别附加到服务器的URL的信息的一部分。 搜索项的识别还包括从使用HTTP的搜索请求不一致的与搜索词相邻的部分的一部分或多个符号中省略。 组合服务器计算机的URL和搜索项的HTTP搜索请求的生成包括使用HTTP与搜索请求相邻地插入与搜索请求一致的一个或多个符号。

公开(公告)号：US20050086212A1

公开(公告)日：2005-04-21

申请号：US10940304

申请日：2004-09-14

申请人： Ian Hughes ,  Nicholas Midgley

发明人： Ian Hughes ,  Nicholas Midgley

IPC分类号： G06F17/30

CPC分类号： G06F17/30864 ,  Y10S707/99933 ,  Y10S707/99936

摘要： System, method and computer program for initiating a search at a server computer. A data base including a URL of the server computer is stored at a client computer. Information entered by a user into the client computer is received. From the information, a search term and the URL of the server computer are identified. Then, an HTTP search request which includes the URL of the server computer and the search term is generated. Then, the HTTP search request is sent to the server computer. The identifying of the URL of the server computer comprises searching the data base for a character string contained in the information that matches the URL of the server computer. The identifying of the search term comprises identifying a portion of the information appended to the URL of the server. The identifying of the search term also comprises omitting from the portion one or more symbols adjacent to the search term which are inconsistent with a search request using HTTP. The generating of the HTTP search request which combines the URL of the server computer and the search term comprises inserting adjacent to the search term one or more symbols consistent with a search request using HTTP.

摘要翻译： 用于在服务器计算机上发起搜索的系统，方法和计算机程序。 包含服务器计算机的URL的数据库存储在客户端计算机中。 接收用户进入客户端计算机的信息。 从信息中，识别搜索项和服务器计算机的URL。 然后，生成包括服务器计算机的URL和搜索项的HTTP搜索请求。 然后，将HTTP搜索请求发送到服务器计算机。 服务器计算机的URL的识别包括在数据库中搜索包含在与服务器计算机的URL匹配的信息中的字符串。 搜索项的识别包括识别附加到服务器的URL的信息的一部分。 搜索项的识别还包括从使用HTTP的搜索请求不一致的与搜索词相邻的部分的一部分或多个符号中省略。 组合服务器计算机的URL和搜索项的HTTP搜索请求的生成包括使用HTTP与搜索请求相邻地插入与搜索请求一致的一个或多个符号。

公开(公告)号：US20050003834A1

公开(公告)日：2005-01-06

申请号：US10871915

申请日：2004-06-18

申请人： Ian Hughes

发明人： Ian Hughes

IPC分类号： H04L29/08 ,  H04W4/02 ,  H04Q7/20

CPC分类号： H04W4/02 ,  H04L67/18

摘要： The invention relates to a method, system and service for processing at a remote device a request from a first device, the method has the steps of receiving a request message to obtain information on location based services available at the physical location of the remote device from the first device, determining a user defined query in the request message, routing the query to an appropriate response service, formulating the response from the response service into a response message, and routing the response message to the first device.

摘要翻译： 本发明涉及一种用于在远程设备处处理来自第一设备的请求的方法，系统和服务，该方法具有以下步骤：接收请求消息以获得关于在远程设备的物理位置处可用的基于位置的服务的信息， 所述第一设备，确定所述请求消息中的用户定义的查询，将所述查询路由到适当的响应服务，将所述响应从所述响应服务制定为响应消息，以及将所述响应消息路由到所述第一设备。

公开(公告)号：US5190937A

公开(公告)日：1993-03-02

申请号：US640069

申请日：1991-01-11

申请人： Roger E. Markwell ,  Ian Hughes

发明人： Roger E. Markwell ,  Ian Hughes

IPC分类号： A61K31/395 ,  A61P29/00 ,  A61P43/00 ,  C07D223/12 ,  C07D225/02 ,  C12N9/99

CPC分类号： C07D223/12 ,  C07D225/02

摘要： Novel compounds of formula (I), and pharmaceutically acceptable salts thereof; their preparation; compositions containing them; and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of the body occurs: ##STR1## in which, R.sub.1 is --OH; alkoxy; aryloxy or aralkyloxy in each of which the aryl group is optionally substituted; --NR.sub.6 R.sub.7, where each of R.sub.6 and R.sub.7 is independently hydrogen or alkyl, or R.sub.6 and R.sub.7 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-membered ring with an optional oxygen or sulphur atom or an optionally substituted second nitrogen atom in the ring; or a group:--NH--CH(R.sub.8)--C(O)--R.sub.9where R.sub.8 is hydrogen; alkyl optionally substituted by --OH, alkoxy, --NR.sub.6 R.sub.7 as defined for R.sub.1, guanidine, --CO.sub.2 H, --CONH.sub.2, --SH, or --S--alkyl; or --CH.sub.2 --Ar where Ar is optionally substituted aryl or heteroaryl; and R.sub.9 is alkoxy; --OH; or --NR.sub.6 R.sub.7 as defined for R.sub.1 ; R.sub.2 is hydrogen; C.sub.2-8 alkanoyl; or optionally substituted aroyl; R.sub.3 is C.sub.3-6 alkyl; and R.sub.4 is --(CH.sub.2).sub.m -- where m is an integer from 4 to 12.

公开(公告)号：US4621089A

公开(公告)日：1986-11-04

申请号：US704621

申请日：1985-02-22

申请人： Robert W. Ward ,  Ian Hughes

发明人： Robert W. Ward ,  Ian Hughes

IPC分类号： A61K31/435 ,  A61P29/00 ,  A61P37/08 ,  C07D231/38 ,  C07D471/04 ,  A61K31/44

CPC分类号： C07D231/38 ,  C07D471/04

摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: X is NR wherein R is hydrogen or C.sub.1-6 alkyl, oxygen, sulphur, SO or SO.sub.2 ;R.sub.1 is COR.sub.5 wherein R.sub.5 is hydroxy, or COR.sub.5 is a pharmaceutically acceptable ester or amide group; or CF.sub.3 ; and R.sub.2 is hydrogen, C.sub.1-6 alkyl or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl; or R.sub.2 is COR.sub.5 as defined or CF.sub.3 and R.sub.1 is hydrogen;R.sub.3 is C.sub.1-10 alkyl, optionally substituted by hydroxy, C.sub.1-4 alkoxy, thiol, C.sub.1-4 alkylthio or NR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 are independently hydrogen or C.sub.1-6 alkyl or together are C.sub.3-6 polymethylene; C.sub.2-10 alkenyl or phenyl optionally substituted by one or two of halogen, CF.sub.3, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, hydroxy, nitro, cyano, C.sub.2-10 acyloxy, NR.sub.8 R.sub.9 wherein R.sub.8 and R.sub.9 are independently selected from hydrogen, C.sub.1-6 alkyl, C.sub.2-7 alkanoyl or C.sub.1-6 alkylsulphonyl or COR.sub.10 wherein R.sub.10 is hydroxy, C.sub.1-6 alkoxy or NR.sub.11 R.sub.12 wherein R.sub.11 and R.sub.12 are independently selected from hydrogen or C.sub.1-6 alkyl; andR.sub.4 is hydrogen; or C.sub.1-4 alkyl or benzyl attached at nitrogen atom 1 or 2 having anti-inflammatory and/or anti-allergy activity, a process for their preparation and their use as pharmaceuticals.

摘要翻译： 式（I）化合物及其药学上可接受的盐：其中：X为NR，其中R为氢或C1-6烷基，氧，硫，SO或SO2; R1是COR5，其中R5是羟基，或COR5是药学上可接受的酯或酰胺基; 或CF3; 且R 2为氢，C 1-6烷基或任选被卤素，CF 3，C 1-4烷氧基或C 1-4烷基取代的苯基; 或R2是如所定义的COR5或CF 3，R 1是氢; R 3是任选被羟基，C 1-4烷氧基，硫醇，C 1-4烷硫基或NR 6 R 7取代的C 1-10烷基，其中R 6和R 7独立地是氢或C 1-6烷基或一起是C 3-6 - 多亚甲基; 任选被一个或两个卤素，CF 3，C 1-4烷氧基，C 1-4烷基，羟基，硝基，氰基，C 2-10酰氧基，NR 8 R 9取代的C 2-10烯基或苯基，其中R 8和R 9独立地选自氢，C 1 C6烷基，C2-7烷酰基或C1-6烷基磺酰基或COR10，其中R10是羟基，C1-6烷氧基或NR11R12，其中R11和R12独立地选自氢或C1-6烷基; R4为氢; 或在具有抗炎和/或抗过敏活性的氮原子1或2上连接的C 1-4烷基或苄基，其制备方法及其作为药物的用途。

公开(公告)号：US08874654B2

公开(公告)日：2014-10-28

申请号：US11393635

申请日：2006-03-30

申请人： Martin J Gale ,  Ian Hughes

发明人： Martin J Gale ,  Ian Hughes

IPC分类号： G06F15/16 ,  G06F9/46 ,  H04L29/08

CPC分类号： H04L67/02 ,  H04L67/2838

摘要： Portlet processing for portal applications aggregating content from sources is provided. This processing may include client intervention and publish/subscribe system use. Topic information used for rendering may be obtained by using a subscription/publisher methodology targeting clients for receipt of the topic information. The topic information from a publish/subscribe system may be inserted into placeholders on a portal page, the placeholders previously created at the client for receipt of the topic information by the client.

摘要翻译： 提供了从源头汇总内容的门户应用程序的Portlet处理。 此处理可能包括客户端干预和发布/订阅系统使用。 用于呈现的主题信息可以通过使用针对客户端的订阅/发布者方法获得主题信息。 来自发布/订阅系统的主题信息可以插入门户页面上的占位符，客户端以前创建的占位符，以便客户端收到主题信息。

公开(公告)号：US08832809B2

公开(公告)日：2014-09-09

申请号：US13485252

申请日：2012-05-31

申请人： Kobus Paulsen ,  Christopher D. Thom ,  Ian Hughes ,  Mark Holland

发明人： Kobus Paulsen ,  Christopher D. Thom ,  Ian Hughes ,  Mark Holland

IPC分类号： G06F7/04 ,  G06F15/16 ,  G06F17/30 ,  H04L29/06 ,  H04M15/00 ,  G06Q20/40 ,  G06F21/44 ,  H04L29/08

CPC分类号： H04L63/0815 ,  G06F21/44 ,  G06Q20/4014 ,  G06Q20/4018 ,  H04L63/107 ,  H04L63/1425 ,  H04L63/168 ,  H04L67/02 ,  H04M15/58

摘要： Various embodiments provide systems for registering a user with one or more websites. Such systems comprise at least one processor configured to: receive an IP address for a computing device being used by the user; and after receiving the IP address: (1) obtain a location associated with the IP address; and (2) identify whether the user is in a jurisdiction that permits the user to register with a website. The systems may then receive one or more parameters obtained from the user, upon which the systems verify an age of the user; determine which of the one or more types of transaction activities the user is permitted to conduct; query one or more registration attempts over a predetermined previous time period to identify duplicate or similar parameters; and verify the user's identity based at least on one of the one or more parameters. Associated methods are also provided.

摘要翻译： 各种实施例提供用于向一个或多个网站注册用户的系统。 这样的系统包括至少一个处理器，其被配置为：接收用户使用的计算设备的IP地址; 并在收到IP地址后：（1）获取与该IP地址相关的位置; 和（2）识别用户是否在允许用户在网站上注册的管辖区。 系统然后可以接收从用户获得的一个或多个参数，系统验证用户的年龄; 确定用户被允许进行的一种或多种类型的交易活动中的哪一种; 在预定的上一时间段内查询一个或多个注册尝试以识别重复的或相似的参数; 并且至少基于一个或多个参数之一来验证用户的身份。 还提供了相关的方法。

公开(公告)号：US20120311151A1

公开(公告)日：2012-12-06

申请号：US13485220

申请日：2012-05-31

申请人： Kobus Paulsen ,  Christopher D. Thom ,  Ian Hughes ,  Mark Holland

发明人： Kobus Paulsen ,  Christopher D. Thom ,  Ian Hughes ,  Mark Holland

IPC分类号： G06F15/173

CPC分类号： H04L63/0815 ,  G06F21/44 ,  G06Q20/4014 ,  G06Q20/4018 ,  H04L63/102 ,  H04L63/107 ,  H04L63/1425 ,  H04L63/168 ,  H04L67/02 ,  H04M15/58

摘要： Various embodiments provide systems and methods for monitoring a user over at least two websites. The systems and methods are configured to: (a) receive self-exclusion information from the user; (b) after receiving the self-exclusion information: (1) associate a unique user identifier that identifies the user with the self-exclusion information; and (2) store the unique user identifier and the self-exclusion information; (c) receive a first request from a first website to validate whether the user can engage in one or more first types of transaction activities; (d) after receiving the first request: (1) query the memory based on the unique user identifier; and (2) in response, send the first website a first indication that the user is excluded from engaging in the at least one of the first types of transaction activities. Second requests for a second website are then handled analogously. Associated methods are likewise provided.

摘要翻译： 各种实施例提供了通过至少两个网站监视用户的系统和方法。 系统和方法被配置为：（a）从用户接收自排除信息; （b）在收到自我排除信息之后：（1）将识别用户的唯一用户标识符与自排除信息相关联; 和（2）存储唯一的用户标识符和自排除信息; （c）从第一网站接收第一请求以验证用户是否可以从事一种或多种第一类交易活动; （d）收到第一个请求后：（1）基于唯一用户标识查询内存; 和（2）作为响应，向第一网站发送用户被排除在参与至少一种第一类交易活动中的第一指示。 然后对第二个网站的第二个请求类似地进行处理。 同样提供了相关方法。

公开(公告)号：US07885667B2

公开(公告)日：2011-02-08

申请号：US12146547

申请日：2008-06-26

申请人： Ian Hughes

发明人： Ian Hughes

IPC分类号： G06F15/16

CPC分类号： H04W4/02 ,  H04L67/18

摘要： The invention relates to a method, system and service for processing at a remote device a request from a first device, the method has the steps of receiving a request message to obtain information on location based services available at the physical location of the remote device from the first device, determining a user defined query in the request message, routing the query to an appropriate response service, formulating the response from the response service into a response message, and routing the response message to the first device.

摘要翻译： 本发明涉及一种用于在远程设备处处理来自第一设备的请求的方法，系统和服务，该方法具有以下步骤：接收请求消息以获得关于在远程设备的物理位置处可用的基于位置的服务的信息， 所述第一设备，确定所述请求消息中的用户定义的查询，将所述查询路由到适当的响应服务，将所述响应从所述响应服务制定为响应消息，以及将所述响应消息路由到所述第一设备。