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公开(公告)号：US09867838B2
公开(公告)日：2018-01-16
申请号：US13393248
申请日：2010-09-01
申请人： Kenneth W. Lyles , Cathleen S. Colon-Emeric , Christopher M. O'Connor , Richard S. Stack , Colleen Stack
发明人： Kenneth W. Lyles , Cathleen S. Colon-Emeric , Christopher M. O'Connor , Richard S. Stack , Colleen Stack
IPC分类号： A61K47/00 , A61K31/663 , A61K31/66
CPC分类号： A61K31/663 , A61K31/66
摘要： The present invention provides for methods for treating and/or reducing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.
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公开(公告)号：US20120208786A1
公开(公告)日：2012-08-16
申请号：US13393248
申请日：2010-09-01
申请人： Kenneth W. Lyles , Cathleen S. Colon-Emeric , Christopher M. O'Connor , Richard S. Stack , Colleen Stack
发明人： Kenneth W. Lyles , Cathleen S. Colon-Emeric , Christopher M. O'Connor , Richard S. Stack , Colleen Stack
IPC分类号： A61K31/675 , A61P9/00 , C07F9/40
CPC分类号： A61K31/663 , A61K31/66
摘要： The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.
摘要翻译： 本发明提供了治疗和/或预防心脏功能障碍的方法和组合物，其通过施用治疗有效量的双膦酸盐，其功能类似物或药学上有效的盐。
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3.发明授权Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors 失效用选择性5-羟色胺再摄取抑制剂抑制血小板活化的方法公开(公告)号：US06245782B1
公开(公告)日：2001-06-12
申请号：US09312987
申请日：1999-05-17
IPC分类号： A61K31445
CPC分类号： A61K31/4525 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/15 , A61K31/343
摘要： The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet activation state is reduced upon administering a SSRI, as measured by one or more platelet activation markers. The invention also relates to methods for treating or preventing an individual at risk for a vascular event, disease or disorder by administering a SSRI.
摘要翻译： 本发明涉及降低个体血小板活化状态的方法，包括施用选择性5-羟色胺再摄取抑制剂（SSRI）。 如通过一种或多种血小板活化标记测量的，施用SSRI时血小板活化状态降低。 本发明还涉及通过施用SSRI来治疗或预防患有血管事件，疾病或病症风险的个体的方法。
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公开(公告)号：US06552014B2
公开(公告)日：2003-04-22
申请号：US09804689
申请日：2001-03-12
IPC分类号： A61K3155
CPC分类号： A61K31/4525 , A61K31/00 , A61K31/135 , A61K31/138 , A61K31/15 , A61K31/343
摘要： The present invention pertains to methods for reducing the platelet activation state in an individual comprising administering a selective serotonin reuptake inhibitor (SSRI). The platelet activation state is reduced upon administering a SSRI, as measured by one or more platelet activation markers. The invention also relates to methods for treating or preventing an individual at risk for a vascular event, disease or disorder by administering a SSRI.
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