公开(公告)号：US20090023710A1

公开(公告)日：2009-01-22

申请号：US11968436

申请日：2008-01-02

申请人： Nigel Vicker ,  Joanna Mary Day ,  Helen Victoria Bailey ,  Wesley Heaton ,  Ana Maria Ramos Gonzalez ,  Christopher Mark Sharland ,  Michael John Reed ,  Atul Purohit ,  Barry Victor Lloyd Potter

发明人： Nigel Vicker ,  Joanna Mary Day ,  Helen Victoria Bailey ,  Wesley Heaton ,  Ana Maria Ramos Gonzalez ,  Christopher Mark Sharland ,  Michael John Reed ,  Atul Purohit ,  Barry Victor Lloyd Potter

IPC分类号： A61K31/55 ,  C07D211/58 ,  C07C233/22 ,  A61P35/00 ,  C07D223/12 ,  A61K31/167

CPC分类号： C07C237/22 ,  C07C233/36 ,  C07D209/20 ,  C07D211/56 ,  C07D211/58 ,  C07D211/62 ,  C07D211/96 ,  C07D215/38 ,  C07D215/44 ,  C07D223/12 ,  C07D223/16 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D451/04

摘要： There is provided a compound having Formula (I) wherein each of R1, R2, R3, R4, R5, R6 and R7 are independently selected from (a) H, (b) R17, —OC(R17)3, —OCH(R17)2, —OCH2R17, —C(R17)3, —CH(R17)2, or —CH2R17 wherein R17 is a halogen; (c) —CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) —SO2-alkyl; and (n) —N(R11)C(O)R13; wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; each of rings A and B are selected from five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring; X is an optional group selected from O, S, S═O, S(═O)2, C═O, S(═O)2NR8, C═ONR9, NR10, wherein R8, R9 and R10 are independently selected from H and hydrocarbyl, wherein n and p are independently selected from 0 and 1; Y is (R11)1-3 wherein each R11 is independently selected from NR12, CR13R14, S(═O)2 and C═O, wherein R12, R13 and R14 are independently selected from Hand hydrocarbyl; Z is selected from (i) six or seven membered ring containing carbon and at least one nitrogen, which may be optionally substituted wherein the substituents may together form further ring fused thereto; and (ii) a —R15—NR16— group wherein R15 is an optionally substituted C1-6 alkyl chain and R16 is selected from H and hydrocarbyl; and R3 is selected from Formula (A).

公开(公告)号：US08119627B2

公开(公告)日：2012-02-21

申请号：US11968436

申请日：2008-01-02

申请人： Nigel Vicker ,  Joanna Mary Day ,  Helen Victoria Bailey ,  Wesley Heaton ,  Ana Maria Ramos Gonzalez ,  Christopher Mark Sharland ,  Michael John Reed ,  Atul Purohit ,  Barry Victor Lloyd Potter

发明人： Nigel Vicker ,  Joanna Mary Day ,  Helen Victoria Bailey ,  Wesley Heaton ,  Ana Maria Ramos Gonzalez ,  Christopher Mark Sharland ,  Michael John Reed ,  Atul Purohit ,  Barry Victor Lloyd Potter

IPC分类号： A61K31/55

CPC分类号： C07C237/22 ,  C07C233/36 ,  C07D209/20 ,  C07D211/56 ,  C07D211/58 ,  C07D211/62 ,  C07D211/96 ,  C07D215/38 ,  C07D215/44 ,  C07D223/12 ,  C07D223/16 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D451/04

摘要： There is provided a compound having Formula (I) wherein each of rings A and B is selected from five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring; X is an optional group selected from O, S, —S═O, —S(═O)2, —C═O, —S(═O)2NR8, —C═ONR9, and —NR10, wherein n and p are independently selected from 0 and 1; Y is (R11)1-3 wherein each R11 is independently selected from —NR12, —CR13R14, —S(═O)2 and —C═O; Z is selected from (i) six or seven membered ring containing carbon and at least one nitrogen, which may be optionally substituted wherein the substituents may together form further ring fused thereto; and (ii) a —R15—NR16— group.

摘要翻译： 提供了具有式（I）的化合物，其中环A和B各自选自5或6元碳环，任选地含有一个或多个选自N，S和O的杂原子，并且任选地与另一个环稠合; X是选自O，S，-S = O，-S（= O）2，-C = O，-S（= O）2 NR 8，-CONONR 9和-NR 10的任选基团，其中n和p 独立地选自0和1; Y是（R 11）1-3，其中每个R 11独立地选自-NR 12，-CR 13 R 14，-S（= O）2和-C≡O; Z选自（i）含有六元或七元环的碳和至少一个氮，其可以是任选取代的，其中取代基可以一起形成稠合的另外的环; 和（ii）-R 15 -NR 16 - 基团。