公开(公告)号：US20040220141A1

公开(公告)日：2004-11-04

申请号：US10858163

申请日：2004-06-01

Applicant: Chromaceutical Advanced Technologies, Inc.

Inventor： Robert A. Beck ,  Robert A. Mateer JR.

IPC: A61K031/715 ,  C08B037/00

CPC classification number: A61K45/06 ,  A61K31/295 ,  A61K31/7016 ,  A61K33/26 ,  Y10T436/10 ,  Y10T436/143333 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255 ,  A61K2300/00

Abstract: A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization. The ability to separate the iron-saccharidic complex responsible for hematinic function, including its lyophilized form, also provides a means for preparing analytical material to verify and validate its pharmacological integrity, patient safety and clinical performance, as well as analytical monitoring, standardization and quality control inspection over hematinic manufacturing processes and establishment of standards for use therewith.

公开(公告)号：US09585908B1

公开(公告)日：2017-03-07

申请号：US14628734

申请日：2015-02-23

Applicant: Chromaceutical Advanced Technologies, Inc.

Inventor： Robert A. Beck ,  Robert A. Mateer, Jr.

IPC: A61K31/714 ,  A61K9/00

CPC classification number: A61K31/714 ,  A61K9/0048 ,  A61K47/36 ,  A61K47/38

Abstract: Combustion reactions release pollutant gases that associate with ocular fluids and tissues which can have an acute ocular impact. The chronic irritation and chemical effects of these gases also promote ocular aging over the lifespan. Instantaneous pollutant effects can be reduced at the time of eye exposure by using an eyewash (collyrium) composition comprising hydroxocobalamin and/or hydroxo(aquo)cobalamin. Such compositions minimize pollutant gas reactions with ocular tissues by (1) deactivating the gases; and (2) expediting their removal from the eye by, for example, aqueous rinsing and dilution.

Abstract translation: 燃烧反应释放与可能引起急性眼睛撞击的眼液和组织相关的污染气体。 这些气体的慢性刺激和化学作用也会延长寿命期间的眼部老化。 通过使用包含羟钴胺素和/或羟基（水）钴胺素的洗眼剂（胶囊）组合物，可以在眼睛接触时减少瞬间污染物的影响。 这种组合物通过（1）使气体失活来最小化与眼组织的污染物气体反应; 和（2）通过例如水性漂洗和稀释来加速其从眼睛的移除。