公开(公告)号：US11981627B1

公开(公告)日：2024-05-14

申请号：US18244933

申请日：2023-09-12

申请人： KING FAISAL UNIVERSITY

发明人： Hany Mohamed Abd El-Lateef Ahmed ,  Saadeldin Elsayed Ibrahim Shabaan ,  Mai Mustafa Khalaf Ali ,  Mohamed Gouda ,  Wael I. Mortada

IPC分类号： G01N1/40 ,  C07C391/02 ,  G01N33/18

CPC分类号： C07C391/02 ,  G01N1/4044 ,  G01N33/1813 ,  Y10T436/107497 ,  Y10T436/255

摘要： Novel organoselenium selective ligands are presented and designed to determine metal ions in a sample. These ligands are used as complexing agents in a dispersive liquid-liquid microextraction procedure of copper and zinc ions. The procedure has a shortened extraction time, minimal organic solvent types, and lower amounts of solvents, as well as easy operation and high enrichment efficiency.

公开(公告)号：US11885722B2

公开(公告)日：2024-01-30

申请号：US18093942

申请日：2023-01-06

申请人： HERO SCIENTIFIC LTD.

发明人： Zvi Feldman ,  Robert Eric Levitz ,  Rinat Adi

IPC分类号： G01N1/22 ,  G01N1/10 ,  G01N1/40

CPC分类号： G01N1/2205 ,  G01N1/4077 ,  G01N2001/1006 ,  G01N2001/1012 ,  G01N2001/4088 ,  Y10T436/255

摘要： A sampling device is provided for concentrating a liquid specimen sample, including a filtration assembly, which includes a tubular container and a plunger. The plunger includes a plunger head and a plunger rod that is shaped so as to define an internal plunger space having a plunger-space proximal opening through a proximal end of the plunger rod. The sampling device is configured such that a filter is removable from the tubular container via the plunger-space proximal opening while the plunger head is within the tubular container. Other embodiments are also described.

公开(公告)号：US11828708B2

公开(公告)日：2023-11-28

申请号：US17383625

申请日：2021-07-23

申请人： University of North Carolina Wilmington

发明人： Mary M. Turbe ,  Lawrence B. Cahoon

IPC分类号： G01N21/64 ,  G01N1/34 ,  G01N1/40 ,  G01N33/18

CPC分类号： G01N21/643 ,  G01N1/34 ,  G01N1/405 ,  G01N1/4055 ,  G01N21/64 ,  G01N33/18 ,  G01N2001/4061 ,  G01N2021/6439 ,  Y10T436/255

摘要： The present subject matter provides processes and kits for identifying the presence of waste water or human-derived pathogens, particularly those associated with the presence of human fecal matter, in surface or subsurface water sources.

公开(公告)号：US11718826B2

公开(公告)日：2023-08-08

申请号：US17406967

申请日：2021-08-19

申请人： Inguran, LLC

发明人： Gary Durack ,  Jeffrey D. Wallace ,  Gary P. Vandre ,  Lon A. Westfall ,  Jeremy T. Hatcher ,  Niraj V. Nayak

IPC分类号： G01N33/48 ,  C12N5/076 ,  C12Q1/02 ,  G01N15/14 ,  C12N5/071 ,  A01N1/02 ,  C12Q3/00 ,  G01N33/50 ,  G01N21/64 ,  C12N5/07 ,  G01N21/63 ,  G01N15/00 ,  G01N15/10

CPC分类号： C12N5/0612 ,  A01N1/0284 ,  C12N5/06 ,  C12N5/061 ,  C12Q1/02 ,  C12Q3/00 ,  G01N15/1404 ,  G01N15/147 ,  G01N15/1459 ,  G01N15/1468 ,  G01N21/6428 ,  G01N33/48 ,  G01N33/5005 ,  G01N21/63 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1406 ,  G01N2015/149 ,  G01N2015/1415 ,  G01N2021/6439 ,  Y10T436/10 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/255 ,  Y10T436/2525 ,  Y10T436/2575 ,  Y10T436/25375

摘要： A multi-channel system for classifying particles in a mixture of particles according to one or more characteristics including a common source of electromagnetic radiation for producing a beam of electromagnetic radiation and a beam splitter for producing multiple beams of electromagnetic radiation for directing multiple beams of electromagnetic radiation to each interrogation location associated with each flow channel of the multi-channel system.

公开(公告)号：US20230230827A1

公开(公告)日：2023-07-20

申请号：US17979972

申请日：2022-11-03

申请人： Purdue Research Foundation

发明人： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

IPC分类号： H01J49/16 ,  C12Q1/6806

CPC分类号： H01J49/167 ,  C12Q1/6806 ,  Y10T436/24 ,  Y10T436/255

摘要： The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

公开(公告)号：US20190221418A1

公开(公告)日：2019-07-18

申请号：US16293017

申请日：2019-03-05

申请人： Purdue Research Foundation

发明人： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

IPC分类号： H01J49/16 ,  C12Q1/6806

CPC分类号： H01J49/167 ,  C12Q1/6806 ,  Y10T436/24 ,  Y10T436/255

摘要： The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

公开(公告)号：US20180318838A1

公开(公告)日：2018-11-08

申请号：US16032183

申请日：2018-07-11

申请人： LUMINEX CORPORATION

发明人： Dylan Hilmer BIRD ,  Jesus CHING ,  Bruce A. JOHNSON ,  Keith E. MORAVICK ,  Bruce RICHARDSON

IPC分类号： B01L7/00 ,  C12Q1/6806 ,  C12Q1/686 ,  B01F5/12 ,  B01F11/00 ,  B01L3/00 ,  B01F15/02 ,  G01N1/38 ,  G01N35/04 ,  G01N35/10

CPC分类号： B01L7/52 ,  B01F5/12 ,  B01F11/0071 ,  B01F15/0203 ,  B01F15/0237 ,  B01F2015/0221 ,  B01F2215/0037 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50851 ,  B01L3/523 ,  B01L3/527 ,  B01L7/00 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/0633 ,  B01L2400/0644 ,  B01L2400/0683 ,  C12Q1/6806 ,  C12Q1/686 ,  G01N1/38 ,  G01N35/1079 ,  G01N2035/0436 ,  Y10T436/118339 ,  Y10T436/25375 ,  Y10T436/255

摘要： Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided, as are methods for using such cartridges. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.

公开(公告)号：US09909969B2

公开(公告)日：2018-03-06

申请号：US15271747

申请日：2016-09-21

申请人： 3M INNOVATIVE PROPERTIES COMPANY

发明人： Kurt J. Halverson ,  Raj Rajagopal ,  Ramasubramani Kuduva Raman Thanumoorthy

IPC分类号： G01N15/04 ,  G01N1/40 ,  B01L3/00 ,  C12Q1/02 ,  G01N21/07 ,  G01N15/00

CPC分类号： G01N15/042 ,  B01L3/5021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2400/0409 ,  C12Q1/02 ,  G01N1/4077 ,  G01N15/04 ,  G01N21/07 ,  G01N2001/4083 ,  G01N2015/0065 ,  G01N2015/045 ,  G01N2333/245 ,  Y10T436/25375 ,  Y10T436/255

摘要： Method for detecting an analyte of interest in a sample. The method can include providing a container including a microstructured surface, and centrifuging the container toward the microstructured surface to form a sediment and a supernatant of the sample. Following centrifugation, the container can be inverted to decant at least a portion of the supernatant of the sample from the second portion, such that a concentrate (e.g., including the sediment) of the sample is retained in the microstructured surface. The concentrate can then be interrogated in the microstructured surface for the analyte of interest. In some embodiments, at least a portion of the second portion can be substantially transparent, such that the concentrate can be interrogated from the outside of the container, without requiring that the container be opened prior to interrogation.

公开(公告)号：US09827552B2

公开(公告)日：2017-11-28

申请号：US14333561

申请日：2014-07-17

申请人： Clemson University

发明人： R. Kenneth Marcus ,  Kenneth A. Christensen

IPC分类号： B01J20/00 ,  B01J20/281 ,  G01N30/50 ,  G01N33/543 ,  B01J20/28 ,  B01J20/285 ,  B01J20/32 ,  B01D15/20 ,  B01D15/38 ,  C07K1/20 ,  G01N30/88

CPC分类号： B01J20/281 ,  B01D15/206 ,  B01D15/3823 ,  B01J20/28023 ,  B01J20/28052 ,  B01J20/285 ,  B01J20/321 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3293 ,  B01J2220/56 ,  C07K1/20 ,  G01N30/50 ,  G01N33/54353 ,  G01N33/54393 ,  G01N2030/8813 ,  Y10T436/255

摘要： A solid phase for use in separation has been modified using an aqueous phase adsorption of a headgroup-modified lipid to generate analyte specific surfaces for use as a stationary phase in separations such as high performance liquid chromatography (HPLC) or solid phase extraction (SPE). The aliphatic moiety of the lipid adsorbs strongly to a hydrophobic solid surface, with the hydrophilic and active headgroups orienting themselves toward the more polar mobile phase, thus allowing for interactions with the desired solutes. The surface modification approach is generally applicable to a diversity of selective immobilization applications such as protein immobilization clinical diagnostics and preparative scale HPLC as demonstrated on capillary-channeled fibers, though the general methodology could be implemented on any hydrophobic solid support material.

公开(公告)号：US09802183B2

公开(公告)日：2017-10-31

申请号：US13352629

申请日：2012-01-18

申请人： John David Hanby

发明人： John David Hanby

IPC分类号： B01J31/06 ,  B01J31/02 ,  G01N33/18 ,  G01N33/24 ,  G01N1/40

CPC分类号： B01J31/06 ,  B01J31/0231 ,  B01J2231/4205 ,  G01N33/1833 ,  G01N33/241 ,  G01N2001/4061 ,  Y10T436/255

摘要： An analytical device configured for the introduction of the liquid or solid sample into a sample chamber where it is extracted by a chlorinated hydrocarbon solvent, wherein the extract then passes into a chamber where it undergoes a Friedel-Crafts (FC) reaction.