公开(公告)号：US20240024346A1

公开(公告)日：2024-01-25

申请号：US18021709

申请日：2021-11-25

申请人： RISEN (SUZHOU) PHARMA TECH CO., LTD. ,  Jiasheng LU ,  Gang CHEN ,  Qiguo ZHANG ,  Xianqi KONG ,  Dawei CHEN ,  Chuanhao HUANG ,  Xingwu ZHU ,  Yuhua ZHANG

发明人： Jiasheng LU ,  Gang CHEN ,  Qiguo ZHANG ,  Xianqi KONG ,  Dawei CHEN ,  Chuanhao HUANG ,  Xingwu ZHU ,  Yuhua ZHANG

IPC分类号： A61K31/7076 ,  C07H19/20 ,  A61K45/06

CPC分类号： A61K31/7076 ,  A61K45/06 ,  C07H19/20

摘要： CD73 (also known as ecto-5′-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I′ and pharmaceutically acceptable esters or salts thereof.