公开(公告)号：US08097259B2

公开(公告)日：2012-01-17

申请号：US12723966

申请日：2010-03-15

Applicant: Tzu-Ming Pan ,  Chun-Lin Lee

Inventor： Tzu-Ming Pan ,  Chun-Lin Lee

IPC: A61K36/06

CPC classification number: A61K36/062 ,  A61K36/899 ,  A61K2300/00

Abstract: This invention provides method for the treatment and prevention of Alzheimer's disease without noticeable side effects caused to patients, comprising administering an effective amount of Monascus-fermented product including Monascus powder and Monascus beverage. The Monascus powder and beverage are prepared through specific fermentation procedures disclosed and comprise monacolins, anti-inflammation agents and anti-oxidant compounds. The Monascus compositions are extracted from fermented red mold rice (RMR).

Abstract translation: 本发明提供治疗和预防阿尔茨海默氏病的方法，对患者无明显副作用，包括施用有效量的红曲霉发酵产物，包括红曲霉和红曲霉饮料。 通过所公开的特定发酵方法制备红曲霉粉末和饮料，并且包含单环素，抗炎剂和抗氧化剂。 从发酵红霉米（RMR）中提取红曲霉成分。

公开(公告)号：US20100273241A1

公开(公告)日：2010-10-28

申请号：US12690379

申请日：2010-01-20

Applicant: Tzu-Ming Pan ,  Chun-Lin Lee

Inventor： Tzu-Ming Pan ,  Chun-Lin Lee

IPC: C12N1/16

CPC classification number: C12N1/16 ,  A23L31/00 ,  A23L31/10

Abstract: The present invention discloses a method for manufacturing red mold dioscorea, and the method comprises the following steps: adding some water with an appropriate ratio to fresh dioscorea or dried dioscorea; sterilizing the dioscorea; after the dioscorea being cooled down, inoculating the dioscorea with Monascus species; cultivating the dioscorea with an appropriate temperature, an appropriate humidity and an appropriate shacking frequency for an appropriate time period; and drying the cultivated red mold dioscorea with an appropriate water content.

Abstract translation: 本发明公开了一种制造红薯薯a的方法，其特征在于包括以下步骤：向新鲜的薯a或干燥的薯：加适量的水; 对薯进行消毒; 在薯a汁冷却后，用红曲霉种接种薯;蓉; 在适当的温度，适当的湿度和适当的分拣频率下培养薯for汁适量的时间; 并用合适的含水量干燥栽培的红霉薯。

公开(公告)号：US08697424B2

公开(公告)日：2014-04-15

申请号：US13465029

申请日：2012-05-07

Applicant: Tzu-Ming Pan ,  Chun-Lin Lee

Inventor： Tzu-Ming Pan ,  Chun-Lin Lee

IPC: C12N1/14 ,  C12N1/00

CPC classification number: C12P17/181 ,  A23L5/00 ,  A23L31/00 ,  A23L31/10 ,  C12N1/16 ,  C12P13/005 ,  C12P17/06

Abstract: The present invention discloses a method for manufacturing red mold dioscorea, and the method comprises the following steps: washing and cutting a fresh dioscorea into pieces with a specific dimension; drying the pieces of the fresh dioscorea for making the dried dioscorea contain a specific water content and a specific sulfur content; adding some water with an appropriate ratio to fresh dioscorea or dried dioscorea; sterilizing the dioscorea; after the dioscorea being cooled down, inoculating the dioscorea with Monascus species; cultivating the dioscorea with an appropriate temperature, an appropriate humidity and an appropriate shacking frequency for an appropriate time period; and drying the cultivated red mold dioscorea with an appropriate water content.

公开(公告)号：US20130012576A1

公开(公告)日：2013-01-10

申请号：US13215414

申请日：2011-08-23

Applicant: Tzu-Ming PAN ,  Chun-Lin LEE ,  Chen-Lun WU

Inventor： Tzu-Ming PAN ,  Chun-Lin LEE ,  Chen-Lun WU

IPC: A61K31/352 ,  A61P9/10 ,  C07D493/04

CPC classification number: A61K31/365 ,  A61K31/353 ,  C07D493/04

Abstract: The present invention discloses a composition for lowering blood lipid and elevating high-density lipoprotein and a method for manufacturing the same; the composition comprises monascin or ankaflavin, or a combination thereof; the manufacturing method comprises the steps of: treating a Monascus fermented product with acetone for three times; elevating the concentration of the Monascus fermented product by a process of decompress concentration; and extracting the monascin and the ankaflavin from the Monascus fermented product with a silica gel column chromatography, a Sephadex LH-20 column chromatography, the silica gel column chromatography, and a preparative high performance liquid chromatography sequentially.

公开(公告)号：US20120220017A1

公开(公告)日：2012-08-30

申请号：US13465029

申请日：2012-05-07

Applicant: Tzu-Ming PAN ,  Chun-Lin LEE

Inventor： Tzu-Ming PAN ,  Chun-Lin LEE

IPC: C12N1/14

CPC classification number: C12P17/181 ,  A23L5/00 ,  A23L31/00 ,  A23L31/10 ,  C12N1/16 ,  C12P13/005 ,  C12P17/06

Abstract: The present invention discloses a method for manufacturing red mold dioscorea, and the method comprises the following steps: washing and cutting a fresh dioscorea into pieces with a specific dimension; drying the pieces of the fresh dioscorea for making the dried dioscorea contain a specific water content and a specific sulfur content; adding some water with an appropriate ratio to fresh dioscorea or dried dioscorea; sterilizing the dioscorea; after the dioscorea being cooled down, inoculating the dioscorea with Monascus species; cultivating the dioscorea with an appropriate temperature, an appropriate humidity and an appropriate shacking frequency for an appropriate time period; and drying the cultivated red mold dioscorea with an appropriate water content.

Abstract translation: 本发明公开了一种制造红薯薯a的方法，所述方法包括以下步骤：将新鲜薯：洗涤并切割成具有特定尺寸的片; 干燥新鲜薯条，使干燥的薯a汁含有特定的含水量和特定的硫含量; 加入一些适量的新鲜水果或干薯条水; 对薯进行消毒; 在薯a汁冷却后，用红曲霉种接种薯;蓉; 在适当的温度，适当的湿度和适当的分拣频率下培养薯for汁适量的时间; 并用合适的含水量干燥栽培的红霉薯。

公开(公告)号：US20090162456A1

公开(公告)日：2009-06-25

申请号：US11963533

申请日：2007-12-21

Applicant: Tzu-Ming PAN ,  Chun-Lin Lee

Inventor： Tzu-Ming PAN ,  Chun-Lin Lee

IPC: A61K36/899 ,  A61P25/28

CPC classification number: A61K36/899

Abstract: This invention presented is a composition and method for prevention and treatment of Alzheimer's disease, the composition comprising monacolins, anti-inflammation agents and anti-oxidant compounds is made by the method of the invention. The composition of the invention has effect on prevention and treatment of Alzheimer's disease without noticeable side effects caused to patients.

Abstract translation: 本发明提供了一种预防和治疗阿尔茨海默病的组合物和方法，通过本发明的方法制备了包含单环素，抗炎剂和抗氧化剂的组合物。 本发明的组合物对预防和治疗阿尔茨海默病具有影响，对患者没有明显的副作用。