公开(公告)号：US20180327795A1

公开(公告)日：2018-11-15

申请号：US16046012

申请日：2018-07-26

申请人： Pyo-Jam Park ,  Tuk-Rai Jeong ,  Hyun-Pil Yang ,  Jin Woo Hwang

发明人： Pyo-Jam Park ,  Tuk-Rai Jeong ,  Hyun-Pil Yang ,  Jin Woo Hwang

IPC分类号： C12P17/16 ,  C12N1/16

CPC分类号： C12P17/162 ,  C12N1/16 ,  C12N9/24 ,  C12P17/06 ,  C12P19/60 ,  C12R1/685

摘要： The present invention relates to a method of preparing an anthocyanin oligomer using a coenzyme derived from an Aspergillus sp. strain, and more particularly to a method of preparing an anthocyanin oligomer by fermenting an anthocyanin monomer with a coenzyme of Aspergillus niger, which is a kind of Aspergillus sp. strain. According to the present invention, in order to overcome contamination problems during the culturing process using Aspergillus niger, a coenzyme of Aspergillus niger is extracted and the fermentation process is performed using the same, whereby an anthocyanin oligomer characterized by reduced concern of contamination and superior radical-scavenging effects, compared to existing anthocyanin monomers, can be produced. Also, an anthocyanin oligomer, obtained through fermentation using glucosidase as an enzyme contained in the coenzyme, can exhibit excellent fermentation efficiency and radical-scavenging ability, and polymerization of the anthocyanin oligomer can be confirmed even upon the fermentation of the enzyme including glucosidase.

公开(公告)号：US20180305709A1

公开(公告)日：2018-10-25

申请号：US15735023

申请日：2016-06-10

申请人： DANMARKS TEKNISKE UNIVERSITET ,  KØBENHAVNS UNIVERSITET

发明人： Rasmus John Normand FRANDSEN ,  Uffe Hasbro MORTENSEN ,  Hilde Cornelijne COUMOU ,  Rubini Maya KANNANGARA ,  Bjørn MADSEN ,  Majse NAFISI ,  Johan ANDERSEN-RANBERG ,  Kenneth Thermann KONGSTAD ,  Finn Thyge OKKELS ,  Paiman KHORSAND-JAMAL ,  Dan STÆRK ,  Birger Lindberg MØLLER

IPC分类号： C12N15/82 ,  C12N9/00 ,  C12P5/00

CPC分类号： C12N15/8257 ,  C12N9/93 ,  C12P5/005 ,  C12P7/26 ,  C12P7/40 ,  C12P17/06 ,  C12P19/60 ,  C12Y203/01 ,  C12Y604/00 ,  C40B50/06

摘要： A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.

公开(公告)号：US20180303792A1

公开(公告)日：2018-10-25

申请号：US15749274

申请日：2016-07-21

申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)

发明人： Fulgencio Saura Calixto ,  Jara Perez Jimenez

IPC分类号： A61K31/352 ,  A23L33/105 ,  C12P17/06 ,  A61P3/00 ,  A61P1/00 ,  A61P35/00 ,  A61K8/49

CPC分类号： A61K31/352 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/42 ,  A61K8/498 ,  A61P1/00 ,  A61P3/00 ,  A61P35/00 ,  C07D311/62 ,  C11B1/04 ,  C12P17/06

摘要： The invention relates to a method for producing a concentrate of polymer proanthocyanidins with a concentration of more than 40%, characterised by the use of enzymatic treatments and by the absence of organic solvents and/or the extraction of organic solvents. This concentrate can be used as a functional ingredient, a food supplement, a cosmetic product and a pharmaceutical product.

公开(公告)号：US10017489B2

公开(公告)日：2018-07-10

申请号：US14904695

申请日：2014-04-21

申请人： SHANGHAI JIAO TONG UNIVERSITY

发明人： Minjuan Xu ,  Jun Xu ,  Zhigang Zhang ,  Yahui Wang

IPC分类号： C07D311/00 ,  C07D311/58 ,  C12P17/06 ,  C12R1/465

CPC分类号： C07D311/58 ,  C12P17/06 ,  C12R1/465

摘要： The present invention opens to the public a method to prepare a benzopyran compound and its use for treating pulmonary fibrosis. A benzopyran compound has a structure (I): in which: R1 represents hydrogen, C1-C4 alkyl, or various remaining amino acid moieties after removal of an amino group; R2 represents hydrogen, C1-C4 alkyl, or various remaining amino acid moieties after removal of an amino group; R3 represents hydrogen, or C1-C4 alkyl; and n is any integer of 1-4, wherein the benzopyran compound is derived from a broth of Streptomyces xiamenensis CGMCC No. 5675 by extraction, separation and purification. The derivatives of xiamenmycin made from the present invention have a higher bioactivity to suppress the proliferation of normal human lung fibroblast, and medicinal products containing the same are useful in the treatment of pulmonary fibrosis.

公开(公告)号：US20180179565A1

公开(公告)日：2018-06-28

申请号：US15887646

申请日：2018-02-02

申请人： Codexis Inc.

发明人： Steven J. Collier ,  Ee Ling Teo ,  Joly Sukumaran ,  Robert J. Wilson ,  Junye Xu

IPC分类号： C12P17/06 ,  C12P7/62 ,  C12N15/52 ,  C12N9/10 ,  C07K14/00

CPC分类号： C12P17/06 ,  C07K14/00 ,  C12N9/1025 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/62 ,  C12Y203/01 ,  Y02P20/52

摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.

公开(公告)号：US20180179564A1

公开(公告)日：2018-06-28

申请号：US15881197

申请日：2018-01-26

申请人： Teewinot Technologies Limited

发明人： Robert Winnicki ,  Marc Donsky ,  Mingyang Sun ,  Richard Peet

IPC分类号： C12P17/06 ,  C12M1/34 ,  C12M1/36 ,  C12P7/22 ,  C12P7/42 ,  C12N9/02 ,  C07C37/74 ,  C07C37/01 ,  C07C29/80 ,  C12M1/00 ,  C12M1/40

CPC分类号： C12P17/06 ,  C07C29/80 ,  C07C37/01 ,  C07C37/74 ,  C12M21/18 ,  C12M29/00 ,  C12M29/04 ,  C12M41/12 ,  C12M41/26 ,  C12M41/30 ,  C12M41/32 ,  C12M41/40 ,  C12M41/48 ,  C12M47/10 ,  C12N9/0004 ,  C12P7/22 ,  C12P7/42 ,  C12Y121/03 ,  C12Y121/03007 ,  C12Y121/03008

摘要： The present invention provides an apparatus and methods for producing tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) and cannabichromenic acid (CBCA) in different ratios. The apparatus comprises: (i) a bioreactor comprising (a) an automated supply system configured to deliver a first automated supply of cannabigerolic acid (CBGA), a cannabinoid acid synthase, and a reaction mixture; and (b) a second automated system to cease the reaction; (ii) a controller configured to modify a property of the reaction mixture to produce the desired products; and (iii) an extractor configured to recover the tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) or cannabidiolic acid (CBDA) and cannabichromenic acid.

公开(公告)号：US20180168979A1

公开(公告)日：2018-06-21

申请号：US15580018

申请日：2016-06-08

申请人： Croda International PLC

发明人： Russell Greig Kerr ,  David Patrick Overy ,  Fabrice Berrué

IPC分类号： A61K8/49 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  C12P17/18 ,  C12P17/06

CPC分类号： A61K8/498 ,  A61K8/35 ,  A61K31/194 ,  A61K31/352 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/60 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/12 ,  C12P17/06 ,  C12P17/181 ,  A61K2300/00

摘要： Use of pycnidione, epolone A, and epolone B as anti-dandruff actives either alone or in combination in anti-dandruff compositions, particularly shampoos and conditioners. The actives are particularly effective against Malassezia yeasts and Malassezia furfur. A method of obtaining pycnidione, epolone A, and epolone B from culturing of Neosetophoma samarorum is also described.

公开(公告)号：US20180168166A1

公开(公告)日：2018-06-21

申请号：US15883532

申请日：2018-01-30

申请人： Marrone Bio Innovations, Inc.

发明人： Ratnakar Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana-Lucia Cordova Kreylos ,  Huazhang Huang

IPC分类号： A01N63/00 ,  A01N63/02 ,  C07D309/14 ,  A01N43/90 ,  A01N43/16 ,  A01N43/76 ,  C12P17/04 ,  A01N43/86 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D263/32 ,  C12R1/01 ,  C12P17/16 ,  C12P17/14 ,  C12P17/06 ,  C12N1/20 ,  C07D513/04 ,  C07D498/14 ,  C07D493/10 ,  C07D263/34 ,  A01N43/74

CPC分类号： A01N43/76 ,  A01N43/00 ,  A01N43/16 ,  A01N43/86 ,  A01N43/90 ,  A01N63/00 ,  A01N63/02 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12N1/20 ,  C12P17/04 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12R1/00 ,  C12R1/01 ,  A01N43/74

摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.

公开(公告)号：US20180135029A1

公开(公告)日：2018-05-17

申请号：US15514120

申请日：2015-09-27

申请人： Symrise AG

发明人： Ludger Wessjohann ,  Anne-Kathrin Bauer ,  Jakob Ley ,  Torsten Geissier ,  Katrin Geissler

IPC分类号： C12N9/10 ,  C12N9/02 ,  C12N15/64 ,  C12P17/06

CPC分类号： C12N9/1007 ,  C12N9/0071 ,  C12N15/64 ,  C12P17/06 ,  C12Y114/14001 ,  C12Y201/01

摘要： A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section (A), comprising or consisting of a gene coding for a CYP450 oxidase, (ii) a second nucleic acid section (B), comprising or consisting of a gene coding for a plant O-methyltransferase, and (b) adding of one or more flavanones to the transgenic microorganism, (c) the conversion of the substrate flavanones by the transgenic microorganism to the corresponding flavonoids, and optionally (d) isolating and purifying of the final products.

公开(公告)号：US09909156B2

公开(公告)日：2018-03-06

申请号：US15199095

申请日：2016-06-30

申请人： Codexis Inc.

发明人： Steven J. Collier ,  Ee Ling Teo ,  Joly Sukumaran ,  Robert J. Wilson ,  Junye Xu

IPC分类号： C12P17/06 ,  C12P7/62 ,  C12N9/10 ,  C07K14/00 ,  C12N15/52

CPC分类号： C12P17/06 ,  C07K14/00 ,  C12N9/1025 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/62 ,  C12Y203/01 ,  Y02P20/52

摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.