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    N-acyl-N′-benzyl-alkylendiamino derivatives
    2.
    发明授权
    N-acyl-N′-benzyl-alkylendiamino derivatives 失效

    公开(公告)号：US07411091B2

    公开(公告)日：2008-08-12

    申请号：US10580367

    申请日：2004-11-12

    申请人： Florian Thaler ,  Cibele Maria Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    发明人： Florian Thaler ,  Cibele Maria Sabido David ,  Laura Faravelli ,  Stefania Gagliardi ,  Elena Colombo ,  Patricia Salvati

    IPC分类号： C07C233/05 ,  C61K31/16 ,  C07D207/00

    CPC分类号： C07D207/27 ,  C07C233/36

    摘要： This invention is related to compounds and use of N-Acyl-N′-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C2-C8 alkyl chain; X is a methylene, oxygen, sulphur or a NR7 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5 are independently hydrogen or C1-C6 alkyl; R6 is a hydrogen or a straight or branched C1-C8 alkyl or linked to R5 can form a five to seven membered lactam; R7 is hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role

    3-aminopyrrolidone derivatives
    3.
    发明授权
    3-aminopyrrolidone derivatives 有权
    3-氨基吡咯烷酮衍生物

    公开(公告)号：US08063039B2

    公开(公告)日：2011-11-22

    申请号：US12610660

    申请日：2009-11-02

    申请人： Florian Thaler ,  Cibele Maria Sabido David ,  Sara Maestroni ,  Luca Francesco Raveglia ,  Patricia Salvati

    发明人： Florian Thaler ,  Cibele Maria Sabido David ,  Sara Maestroni ,  Luca Francesco Raveglia ,  Patricia Salvati

    IPC分类号： A61K31/55 ,  A61K31/4412 ,  A61K31/4015

    CPC分类号： C07D207/273 ,  A61K31/4015 ,  A61K31/4412 ,  A61K31/55 ,  C07D211/76

    摘要： A method for treating pain, migraine, inflammation, gastrointestinal tract disorders, disorders of the genito-urinary tract, ophthalmic diseases or obesity in a subject, the method including administering to the subject an effective amount of a compound of a general formula, specific examples of which include 3-(4-Butyloxy-benzylamino)-pyrrolidin-2-one, 3-[4-(4-trifluorobutyloxy)-benzylamino]-pyrrolidin-2-one, 3-(4-Pentyloxy-benzylamino)-pyrrolidin-2-one, 3-[4-(5-trifluoropentyloxy)-benzylamino]-pyrrolidin-2-one, and 3-(4-Phenylethyl-benzylamino)-pyrrolidin-2-one.

    摘要翻译： 一种用于治疗受试者的疼痛，偏头痛，炎症，胃肠道疾病，泌尿系泌尿系疾病，眼科疾病或肥胖的方法，所述方法包括向受试者施用有效量的通式化合物，具体实例 其中包括3-（4-丁氧基 - 苄基氨基） - 吡咯烷-2-酮，3- [4-（4-三氟丁氧基） - 苄基氨基] - 吡咯烷-2-酮，3-（4-戊氧基 - 苄基氨基） - 吡咯烷 -2-酮，3- [4-（5-三氟戊基氧基） - 苄基氨基] - 吡咯烷-2-酮和3-（4-苯乙基 - 苄基氨基） - 吡咯烷-2-酮。

    Cyclopentyl derivatives
    5.
    发明授权
    Cyclopentyl derivatives 有权
    环戊基衍生物

    公开(公告)号：US07265244B2

    公开(公告)日：2007-09-04

    申请号：US10580366

    申请日：2004-11-12

    申请人： Piero Melloni ,  Cibele Maria Sabido David ,  Alessandra Restivo ,  Roberto Forlani ,  Patricia Salvati

    发明人： Piero Melloni ,  Cibele Maria Sabido David ,  Alessandra Restivo ,  Roberto Forlani ,  Patricia Salvati

    IPC分类号： C07C233/58 ,  C07C237/20

    CPC分类号： C07C237/24 ,  C07C2601/08

    摘要： This invention is related to novel cyclopentyl derivatives of the following general Formula (I), wherein X is methylene, oxygen, sulphur or a NR7 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5,R6, R7 are independently hydrogen or C1-C6alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefor useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

    摘要翻译： 本发明涉及以下通式（I）的新环戊基衍生物，其中X是亚甲基，氧，硫或NR 7基团; R 1是直链或支链C 1 -C 8烷基或C 3 -C 8烷基 亚烷基或C 3 -C 8亚炔基链，任选被CF 3，苯基，苯氧基或萘基取代，芳环 任选地被一个或多个C 1 -C 4烷基，卤素，三氟甲基，羟基或C 1 -C 4烷基取代， 烷氧基; R 2，R 3，R 3独立地是氢，C 1 -C 3 - 烷基链，卤素，三氟甲基， 羟基或C 1 -C 4烷氧基; R 4，R 5，R 6，R 7，R 7独立地是氢或C 1〜 C 1 -C 6烷基; 其作为钠和/或钙通道调节剂具有活性的药学上可接受的盐，并且可用于预防，减轻和治愈广泛范围的病症，包括但不限于神经性，精神病学，心血管疾病，炎症性，眼科，泌尿系统 ，代谢和胃肠道疾病，其中上述机制被描述为发挥病理作用。