公开(公告)号：US08617827B2

公开(公告)日：2013-12-31

申请号：US13395323

申请日：2009-09-10

申请人： Stefan W. Hell ,  Vladimir N. Belov ,  Vadim P. Boyarskiy ,  Christian A. Wurm ,  Stefan Jakobs ,  Claudia Geisler

发明人： Stefan W. Hell ,  Vladimir N. Belov ,  Vadim P. Boyarskiy ,  Christian A. Wurm ,  Stefan Jakobs ,  Claudia Geisler

IPC分类号： G01N33/53 ,  C07D285/06 ,  C12Q1/02 ,  C09B46/00

CPC分类号： C09B11/24

摘要： The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1=O, A2=N, A3=C; G2: A1=S, A2=N, A3=C; G3: A1=O, A2=O, A3=N; G4: A1=S, A2=O, A3=N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420 nm) generate fluorescent rhodamine or carbopyronine derivatives and small non-toxic fragments such as N2 or N2O. The invention also relates to methods for preparing such compounds and to the use of these compounds for optical microscopy and imaging techniques.

摘要翻译： 本发明涉及以下通式G1-G4（I），G1：A1 = O，A2 = N，A3 = C的新型可光致发生罗丹明或卡吡龙衍生物。 G2：A1 = S，A2 = N，A3 = C; G3：A1 = O，A2 = O，A3 = N; G4：A1 = S，A2 = O，A3 = N; 包括紫外光吸收发色团，其在254-490nm（优选在375-420nm）下照射光解后产生荧光罗丹明或卡吡喃衍生物和小的无毒片段如N 2或N 2 O。 本发明还涉及制备这些化合物的方法以及这些化合物用于光学显微镜和成像技术的用途。

公开(公告)号：US20120202216A1

公开(公告)日：2012-08-09

申请号：US13395323

申请日：2009-09-10

申请人： Stefan W. Hell ,  Vladimir N. Belov ,  Vadim P. Boyarskiy ,  Christian A. Wurm ,  Stefan Jakobs ,  Claudia Geisler

发明人： Stefan W. Hell ,  Vladimir N. Belov ,  Vadim P. Boyarskiy ,  Christian A. Wurm ,  Stefan Jakobs ,  Claudia Geisler

IPC分类号： G01N33/53 ,  C07D285/06 ,  C12Q1/02 ,  C09B46/00

CPC分类号： C09B11/24

摘要： The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1=O, A2=N, A3=C; G2: A1=S, A2=N, A3=C; G3: A1=O, A2=O, A3=N; G4: A1=S, A2=O, A3=N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420 nm) generate fluorescent rhodamine or carbopyronine derivatives and small non-toxic fragments such as N2 or N2O. The invention also relates to methods for preparing such compounds and to the use of these compounds for optical microscopy and imaging techniques.

摘要翻译： 本发明涉及以下通式G1-G4（I），G1：A1 = O，A2 = N，A3 = C的新型可光致发生罗丹明或卡吡龙衍生物。 G2：A1 = S，A2 = N，A3 = C; G3：A1 = O，A2 = O，A3 = N; G4：A1 = S，A2 = O，A3 = N; 包括紫外光吸收发色团，其在254-490nm（优选在375-420nm）下照射光解后产生荧光罗丹明或卡吡喃衍生物和小的无毒片段如N 2或N 2 O。 本发明还涉及制备这些化合物的方法以及这些化合物用于光学显微镜和成像技术的用途。