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    NOVEL PHOTOACTIVABLE FLUORESCENT DYES FOR OPTICAL MICROSCOPY AND IMAGING TECHNIQUES
    1.
    发明申请
    NOVEL PHOTOACTIVABLE FLUORESCENT DYES FOR OPTICAL MICROSCOPY AND IMAGING TECHNIQUES 有权
    用于光学显微镜和成像技术的新型可光化荧光染料

    公开(公告)号：US20120202216A1

    公开(公告)日：2012-08-09

    申请号：US13395323

    申请日：2009-09-10

    申请人： Stefan W. Hell ,  Vladimir N. Belov ,  Vadim P. Boyarskiy ,  Christian A. Wurm ,  Stefan Jakobs ,  Claudia Geisler

    发明人： Stefan W. Hell ,  Vladimir N. Belov ,  Vadim P. Boyarskiy ,  Christian A. Wurm ,  Stefan Jakobs ,  Claudia Geisler

    IPC分类号： G01N33/53 ,  C07D285/06 ,  C12Q1/02 ,  C09B46/00

    CPC分类号： C09B11/24

    摘要： The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1=O, A2=N, A3=C; G2: A1=S, A2=N, A3=C; G3: A1=O, A2=O, A3=N; G4: A1=S, A2=O, A3=N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420 nm) generate fluorescent rhodamine or carbopyronine derivatives and small non-toxic fragments such as N2 or N2O. The invention also relates to methods for preparing such compounds and to the use of these compounds for optical microscopy and imaging techniques.

    摘要翻译： 本发明涉及以下通式G1-G4（I），G1：A1 = O，A2 = N，A3 = C的新型可光致发生罗丹明或卡吡龙衍生物。 G2：A1 = S，A2 = N，A3 = C; G3：A1 = O，A2 = O，A3 = N; G4：A1 = S，A2 = O，A3 = N; 包括紫外光吸收发色团，其在254-490nm（优选在375-420nm）下照射光解后产生荧光罗丹明或卡吡喃衍生物和小的无毒片段如N 2或N 2 O。 本发明还涉及制备这些化合物的方法以及这些化合物用于光学显微镜和成像技术的用途。

    Photoactivable fluorescent dyes for optical microscopy and imaging techniques
    2.
    发明授权
    Photoactivable fluorescent dyes for optical microscopy and imaging techniques 有权
    用于光学显微镜和成像技术的可光化荧光染料

    公开(公告)号：US08617827B2

    公开(公告)日：2013-12-31

    申请号：US13395323

    申请日：2009-09-10

    申请人： Stefan W. Hell ,  Vladimir N. Belov ,  Vadim P. Boyarskiy ,  Christian A. Wurm ,  Stefan Jakobs ,  Claudia Geisler

    发明人： Stefan W. Hell ,  Vladimir N. Belov ,  Vadim P. Boyarskiy ,  Christian A. Wurm ,  Stefan Jakobs ,  Claudia Geisler

    IPC分类号： G01N33/53 ,  C07D285/06 ,  C12Q1/02 ,  C09B46/00

    CPC分类号： C09B11/24

    摘要： The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1=O, A2=N, A3=C; G2: A1=S, A2=N, A3=C; G3: A1=O, A2=O, A3=N; G4: A1=S, A2=O, A3=N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420 nm) generate fluorescent rhodamine or carbopyronine derivatives and small non-toxic fragments such as N2 or N2O. The invention also relates to methods for preparing such compounds and to the use of these compounds for optical microscopy and imaging techniques.

    摘要翻译： 本发明涉及以下通式G1-G4（I），G1：A1 = O，A2 = N，A3 = C的新型可光致发生罗丹明或卡吡龙衍生物。 G2：A1 = S，A2 = N，A3 = C; G3：A1 = O，A2 = O，A3 = N; G4：A1 = S，A2 = O，A3 = N; 包括紫外光吸收发色团，其在254-490nm（优选在375-420nm）下照射光解后产生荧光罗丹明或卡吡喃衍生物和小的无毒片段如N 2或N 2 O。 本发明还涉及制备这些化合物的方法以及这些化合物用于光学显微镜和成像技术的用途。

    NOVEL HYDROPHILIC AND LIPOPHILIC RHODAMINES FOR LABELLING AND IMAGING
    5.
    发明申请
    NOVEL HYDROPHILIC AND LIPOPHILIC RHODAMINES FOR LABELLING AND IMAGING 有权
    用于标签和成像的新型水解和液体罗丹明

    公开(公告)号：US20120100559A1

    公开(公告)日：2012-04-26

    申请号：US13266775

    申请日：2010-04-26

    申请人： Stefan Hell ,  Vladimir N. Belov ,  Kirill Kolmakov ,  Volker Westphal ,  Marcel Lauterbach ,  Stefan Jakobs ,  Christian Wurm ,  Christian Eggeling ,  Christian Ringemann

    发明人： Stefan Hell ,  Vladimir N. Belov ,  Kirill Kolmakov ,  Volker Westphal ,  Marcel Lauterbach ,  Stefan Jakobs ,  Christian Wurm ,  Christian Eggeling ,  Christian Ringemann

    IPC分类号： G01N33/567 ,  C07D491/22 ,  C07H21/00 ,  C12Q1/02 ,  C07H1/00

    CPC分类号： C07D491/22 ,  C09B11/24 ,  G01N33/582

    摘要： The invention relates to novel and improved photostable rhodamine dyes of the general structural formulae I or II and their uses as fluorescent markers, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional and stimulated emission depletion (STED) microscopy and fluorescence correlation spectroscopy. The partially deuterated analogues are useful as molecular mass distribution tags in mass spectroscopic applications. wherein R1=an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group; R2═H, an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group, or an unsubstituted or substituted aryl group or heteroaryl group, or any combination of such groups; X═CH2, C═O, C═NORa, C═NNRaNRb, CH(ORa), O, S, SO, SO2, or any other derivatives of these groups, with Ra and Rb independently being H or an organic residue, in particular an unsubstituted or substituted (cyclo) alkyl group or heterocycloalkyl group, an unsubstituted or substituted aryl group or heteroaryl group; Z=a negatively charged group with 1, 2, 3, 4 or 5 charges per anion.

    摘要翻译： 本发明涉及通用结构式I或II的新型和改进的光稳定罗丹明染料及其作为荧光标记物的用途。 用于免疫染色和光谱和微观应用，特别是在常规和受激发射耗尽（STED）显微镜和荧光相关光谱学中。 部分氘代类似物可用作质谱分析应用中的分子量分布标签。 其中R1 =未取代或取代的烷基，包括环烷基或杂环烷基; R 2 = H，未取代或取代的烷基，包括环烷基或杂环烷基，或未取代或取代的芳基或杂芳基，或这些基团的任何组合; X = CH 2，C = O，C = NOR a，C = NR N R a R b，CH（OR a），O，S，SO，SO 2或这些基团的任何其它衍生物，其中Ra和Rb独立地为H或有机残基 特别是未取代或取代的（环）烷基或杂环烷基，未取代或取代的芳基或杂芳基; Z =带负电荷的基团，每个阴离子具有1,2,3,4或5个电荷。

    Hydrophilic and lipophilic rhodamines for labelling and imaging
    6.
    发明授权
    Hydrophilic and lipophilic rhodamines for labelling and imaging 有权
    亲水和亲脂罗丹明用于标记和成像

    公开(公告)号：US08580579B2

    公开(公告)日：2013-11-12

    申请号：US13266775

    申请日：2010-04-26

    申请人： Stefan Hell ,  Vladimir N. Belov ,  Kirill Kolmakov ,  Volker Westphal ,  Marcel Lauterbach ,  Stefan Jakobs ,  Christian Wurm ,  Christian Eggeling ,  Christian Ringemann

    发明人： Stefan Hell ,  Vladimir N. Belov ,  Kirill Kolmakov ,  Volker Westphal ,  Marcel Lauterbach ,  Stefan Jakobs ,  Christian Wurm ,  Christian Eggeling ,  Christian Ringemann

    IPC分类号： G01N33/533 ,  G01N33/532 ,  G01N21/76

    CPC分类号： C07D491/22 ,  C09B11/24 ,  G01N33/582

    摘要： The invention relates to novel and improved photostable rhodamine dyes of the general structural formulae I or II and their uses as fluorescent markers, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional and stimulated emission depletion (STED) microscopy and fluorescence correlation spectroscopy. The partially deuterated analogues are useful as molecular mass distribution tags in mass spectroscopic applications, wherein R1=an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group; R2=H, an unsubstituted or substituted alkyl group, including a cycloalkyl group, or heterocycloalkyl group, or an unsubstituted or substituted aryl group or heteroaryl group, or any combination of such groups; X=CH2, C═O, C═NORa, C═NNRaNRb, CH(ORa), O, S, SO, SO2, or any other derivatives of these groups, with Ra and Rb independently being H or an organic residue, in particular an unsubstituted or substituted (cyclo)alkyl group or heterocycloalkyl group, an unsubstituted or substituted aryl group or heteroaryl group; Z=a negatively charged group with 1, 2, 3, 4 or 5 charges per anion.

    摘要翻译： 本发明涉及通用结构式I或II的新型和改进的光稳定罗丹明染料及其作为荧光标记物的用途。 用于免疫染色和光谱和微观应用，特别是在常规和受激发射耗尽（STED）显微镜和荧光相关光谱学中。 部分氘代类似物可用作质谱应用中的分子量分布标签，其中R1 =未取代或取代的烷基，包括环烷基或杂环烷基; R 2 = H，未取代或取代的烷基，包括环烷基或杂环烷基，或未取代或取代的芳基或杂芳基，或这些基团的任何组合; X = CH2，C = O，C = NORa，C = NNRaNRb，CH（ORa），O，S，SO，SO2或这些基团的任何其他衍生物，其中Ra和Rb独立地为H或有机残基， 特别是未取代或取代的（环）烷基或杂环烷基，未取代或取代的芳基或杂芳基; Z =带负电荷的基团，每个阴离子具有1,2,3,4或5个电荷。