公开(公告)号：US20110166147A1

公开(公告)日：2011-07-07

申请号：US12674525

申请日：2008-08-20

申请人： Angus Macleod ,  Dale Robert Mitchell ,  Nicholas John Palmer ,  Michael Daniel Goldsmith ,  Clifford John Harris ,  Christophe Claude Parsy

发明人： Angus Macleod ,  Dale Robert Mitchell ,  Nicholas John Palmer ,  Michael Daniel Goldsmith ,  Clifford John Harris ,  Christophe Claude Parsy

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  A61P31/12

CPC分类号： C07D487/04

摘要： Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

摘要翻译： 公开了具有由下式表示的式的新型咪唑并吡嗪化合物：式（I）。 化合物可以制备成药物组合物，并且可用于预防和治疗有需要的患者中的病毒感染，特别是HCV，HRV，Sb和/或CVB。

公开(公告)号：US07893058B2

公开(公告)日：2011-02-22

申请号：US11803015

申请日：2007-05-11

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。

公开(公告)号：US07667036B2

公开(公告)日：2010-02-23

申请号：US11202035

申请日：2005-08-12

申请人： Tomomi Kosugi ,  Minoru Imai ,  Hiroaki Makino ,  Mika Takakuwa ,  Gen Unoki ,  Kenichiro Kataoka ,  Dale Robert Mitchell ,  Donald James Simpson ,  Clifford John Harris ,  Joelle Le ,  Yuko Yamakoshi

发明人： Tomomi Kosugi ,  Minoru Imai ,  Hiroaki Makino ,  Mika Takakuwa ,  Gen Unoki ,  Kenichiro Kataoka ,  Dale Robert Mitchell ,  Donald James Simpson ,  Clifford John Harris ,  Joelle Le ,  Yuko Yamakoshi

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/04 ,  A61P25/28

CPC分类号： C07D487/04

摘要： The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent MAPKAP-K2 inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for MAPKAP-K2 mediated disorder, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.

摘要翻译： 由式I表示的吡唑并[1,5-a]嘧啶衍生物及其药学上可接受的盐表现出优异的MAPKAP-K2抑制活性。 因此，包含化合物作为有效成分的药物预期可用作MAPKAP-K2介导的病症如炎性疾病，自身免疫性疾病，破坏性骨病，癌症和/或肿瘤生长的治疗或预防剂。

公开(公告)号：US08362018B2

公开(公告)日：2013-01-29

申请号：US12674525

申请日：2008-08-20

申请人： Angus MacLeod ,  Dale Robert Mitchell ,  Nicholas John Palmer ,  Michael Daniel Goldsmith ,  Clifford John Harris ,  Christophe Claude Parsy

发明人： Angus MacLeod ,  Dale Robert Mitchell ,  Nicholas John Palmer ,  Michael Daniel Goldsmith ,  Clifford John Harris ,  Christophe Claude Parsy

IPC分类号： A61K31/495

CPC分类号： C07D487/04

摘要： Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

摘要翻译： 公开了具有下列表示的式的新型咪唑并吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗病毒感染，特别是HCV，HRV，Sb和/或CVB中的HCV 有需要的患者。

公开(公告)号：US08178530B2

公开(公告)日：2012-05-15

申请号：US12970632

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：US08173656B2

公开(公告)日：2012-05-08

申请号：US12970659

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。

公开(公告)号：US20110092497A1

公开(公告)日：2011-04-21

申请号：US12970632

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/4985 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：US20110218178A1

公开(公告)日：2011-09-08

申请号：US12970659

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： A61K31/635 ,  C07D487/04 ,  A61K31/4985 ,  C07D413/14 ,  A61K31/5377 ,  A61P19/02 ,  A61P29/00

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。