公开(公告)号：US08148369B2

公开(公告)日：2012-04-03

申请号：US12151585

申请日：2008-05-07

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/50 ,  A61K31/535 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

公开(公告)号：US20100298300A1

公开(公告)日：2010-11-25

申请号：US12399979

申请日：2009-03-08

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

IPC分类号： A61K31/551 ,  A61K31/5377 ,  A61K31/519 ,  C07D487/04 ,  C07D243/08 ,  A61P29/00 ,  A61P19/02 ,  A61P9/10 ,  A61P9/00

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。

公开(公告)号：US09006237B2

公开(公告)日：2015-04-14

申请号：US13411450

申请日：2012-03-02

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/503 ,  A61K31/4985 ,  C07D403/12 ,  C07D407/04 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

公开(公告)号：US20110218178A1

公开(公告)日：2011-09-08

申请号：US12970659

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： A61K31/635 ,  C07D487/04 ,  A61K31/4985 ,  C07D413/14 ,  A61K31/5377 ,  A61P19/02 ,  A61P29/00

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。

公开(公告)号：US07951818B2

公开(公告)日：2011-05-31

申请号：US11998818

申请日：2007-11-30

申请人： Paul John Edwards ,  Sébastien Laurent Xavier Martina ,  Martin James Inglis Andrews ,  Grégory Louis Joseph Bar ,  Brigitte Allart ,  Andrew Burritt ,  Xueliang Tao ,  Friedrich Erich Karl Kroll

发明人： Paul John Edwards ,  Sébastien Laurent Xavier Martina ,  Martin James Inglis Andrews ,  Grégory Louis Joseph Bar ,  Brigitte Allart ,  Andrew Burritt ,  Xueliang Tao ,  Friedrich Erich Karl Kroll

IPC分类号： A61K31/44

CPC分类号： C07D471/04

摘要： Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型咪唑并吡啶化合物：该化合物可以制备成药物组合物，并可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例 ，ECM降解，关节降解和/或炎症等。

公开(公告)号：US07977352B2

公开(公告)日：2011-07-12

申请号：US11998817

申请日：2007-11-30

申请人： Paul John Edwards ,  Wolfgang Schmidt ,  Veronique Birault ,  Friedrich Erich Karl Kroll ,  Andrew Burritt ,  Xueliang Tao ,  Martin James Inglis Andrews ,  Sébastien Laurent Xavier Martina

发明人： Paul John Edwards ,  Wolfgang Schmidt ,  Veronique Birault ,  Friedrich Erich Karl Kroll ,  Andrew Burritt ,  Xueliang Tao ,  Martin James Inglis Andrews ,  Sébastien Laurent Xavier Martina

IPC分类号： A61K31/44

CPC分类号： C07D471/04

摘要： Novel triazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型三唑并吡啶化合物：该化合物可以制备成药物组合物，并可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例 ，ECM降解，关节降解和/或炎症等。

公开(公告)号：US20110118269A1

公开(公告)日：2011-05-19

申请号：US12940710

申请日：2010-11-05

申请人： Piet Tom Bert Paul WIGERINCK ,  Martin James Inglis ANDREWS ,  Marc Maurice Germain De WEER ,  Nicholas Luc SABOURAULT ,  Stefan Christian KLUGE

发明人： Piet Tom Bert Paul WIGERINCK ,  Martin James Inglis ANDREWS ,  Marc Maurice Germain De WEER ,  Nicholas Luc SABOURAULT ,  Stefan Christian KLUGE

IPC分类号： A61K31/4985 ,  C07D487/08 ,  A61P29/00 ,  A61P9/10 ,  A61P17/06 ,  A61P37/06 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel salts of a [1.2.4]triazolo[1,5-a]pyrazine compound according to Formula I: The salts may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, and others.

摘要翻译： 式I的[1.2.4]三唑并[1,5-a]吡嗪化合物的新盐可以制备成药物组合物，可用于预防和治疗哺乳动物中的各种病症，包括 人，包括非限制性的例子，炎症等。

公开(公告)号：US07893058B2

公开(公告)日：2011-02-22

申请号：US11803015

申请日：2007-05-11

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。

公开(公告)号：US20090286798A1

公开(公告)日：2009-11-19

申请号：US12436219

申请日：2009-05-06

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Hervé Van De Poël ,  Grégory Louis Joseph Bar

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Hervé Van De Poël ,  Grégory Louis Joseph Bar

IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61P29/00

CPC分类号： C07D519/00

摘要： Novel[1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪和咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可以使用 用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症等。

公开(公告)号：US20090131446A1

公开(公告)日：2009-05-21

申请号：US12151586

申请日：2008-05-07

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Gregory Louis Joseph Bar

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Gregory Louis Joseph Bar

IPC分类号： A61K31/4985 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

摘要翻译： 公开了具有下列表示的式的新型稠合吡嗪化合物：该化合物可以制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括以非限制性方式 例如炎症，类风湿关节炎等。