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公开(公告)号:US06916488B1
公开(公告)日:2005-07-12
申请号:US09615305
申请日:2000-07-13
申请人: Wolfgang Meier , Thomas Hirt , Corinne Nardin
发明人: Wolfgang Meier , Thomas Hirt , Corinne Nardin
CPC分类号: A61K9/5146 , A61K9/5192
摘要: Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also be used. The copolymers may be crosslinked to form nanocapsules. Crosslinking can be accomplished using a variety of methods, including end to end polymerization of copolymers having terminal unsaturated groups. Molecules, such as membrane proteins, can be incorporated into the wall of the vesicles or nanocapsules.
摘要翻译: 公开了由两亲共聚物制成的囊泡。 两亲共聚物可以是ABA共聚物,其中A和B之一是亲水的,另一个是疏水的。 AB共聚物也可以使用。 共聚物可以交联以形成纳米胶囊。 可以使用多种方法实现交联,包括具有末端不饱和基团的共聚物的端对端聚合。 可以将诸如膜蛋白的分子掺入囊泡或纳米胶囊的壁中。
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公开(公告)号:US06723814B2
公开(公告)日:2004-04-20
申请号:US09859177
申请日:2001-05-16
IPC分类号: C08F246
CPC分类号: A61K9/009 , B01D69/02 , B01D69/122 , B01D69/141 , B01D71/44 , B01D71/80 , C08J5/2256 , C08J2383/02 , G01N27/40
摘要: Membranes made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. The copolymers may be crosslinked to form more stable structures. Crosslinking can be accomplished using a variety of methods, including end to end polymerization of copolymers having terminal unsaturated groups. Molecules such as membrane proteins can be incorporated into the membrane to allow the transport there through of selected components.
摘要翻译: 公开了由两亲共聚物制成的膜。 两亲共聚物可以是ABA共聚物,其中A和B之一是亲水的,另一个是疏水的。 共聚物可以交联以形成更稳定的结构。 可以使用多种方法实现交联,包括具有末端不饱和基团的共聚物的端对端聚合。 诸如膜蛋白的分子可以并入膜中,以允许通过选定的组分输送。
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