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公开(公告)号：US06916488B1
公开(公告)日：2005-07-12
申请号：US09615305
申请日：2000-07-13
申请人： Wolfgang Meier , Thomas Hirt , Corinne Nardin
发明人： Wolfgang Meier , Thomas Hirt , Corinne Nardin
CPC分类号： A61K9/5146 , A61K9/5192
摘要： Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also be used. The copolymers may be crosslinked to form nanocapsules. Crosslinking can be accomplished using a variety of methods, including end to end polymerization of copolymers having terminal unsaturated groups. Molecules, such as membrane proteins, can be incorporated into the wall of the vesicles or nanocapsules.
摘要翻译： 公开了由两亲共聚物制成的囊泡。 两亲共聚物可以是ABA共聚物，其中A和B之一是亲水的，另一个是疏水的。 AB共聚物也可以使用。 共聚物可以交联以形成纳米胶囊。 可以使用多种方法实现交联，包括具有末端不饱和基团的共聚物的端对端聚合。 可以将诸如膜蛋白的分子掺入囊泡或纳米胶囊的壁中。
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公开(公告)号：US20080260833A1
公开(公告)日：2008-10-23
申请号：US12148407
申请日：2008-04-18
申请人： Thomas Hirt , Wolfgang Meier , Zhihua Lu , Xianbo Hu
发明人： Thomas Hirt , Wolfgang Meier , Zhihua Lu , Xianbo Hu
IPC分类号： A61K9/10
CPC分类号： A61K47/34 , A61K9/06 , A61K9/1273
摘要： A drug delivery vehicle having active agent loaded vesicles in a hydrogel matrix; desirably either or both of the vesicles and matrix are made of at least one stimulus responsive polymer so that active agent is released in response to contact with a stimulus.
摘要翻译： 一种在水凝胶基体中具有负载囊泡的活性剂的药物递送载体; 理想地，小泡和基质中的任一个或两个由至少一种刺激响应性聚合物制成，使得响应于与刺激的接触而释放活性剂。
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公开(公告)号：US20080305149A1
公开(公告)日：2008-12-11
申请号：US12157114
申请日：2008-06-06
申请人： Thomas Hirt , Zhihue Lu , Wolfgang Meier , Mansoor Amiji
发明人： Thomas Hirt , Zhihue Lu , Wolfgang Meier , Mansoor Amiji
CPC分类号： A61K9/107 , A61K9/0053 , A61K47/34 , C08G77/452
摘要： Vesicles for delivery of active macromolecules which are formed from amphiphilic segmented copolymers having one or more mucoadhesive groups or regions and which can be used for delivery of an active agent to an area of the body having a mucous membrane, such as but not limited to the gastrointestinal tract.
摘要翻译： 用于递送活性大分子的囊泡，其由具有一个或多个粘膜粘附基团或区域的两亲性分段共聚物形成，并且可用于将活性剂递送至具有粘膜的身体区域，例如但不限于 胃肠道。
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公开(公告)号：US07956135B2
公开(公告)日：2011-06-07
申请号：US12321442
申请日：2009-01-21
IPC分类号： C08G77/38
CPC分类号： C08G77/42
摘要： The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical moldings, for example ophthalmic moldings such as in particular contact lenses.
摘要翻译： 本发明涉及新的可交联共聚物，其中变量如权利要求中所定义。 本发明的共聚物特别可用于制造生物医学模制品，例如眼用模制品，例如隐形眼镜。
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5.发明申请Self-contained, self-snubbed, HID dimming module that exhibits non-zero crossing detection switching 有权独立的自缓冲HID调光模块，显示非零交叉检测切换公开(公告)号：US20060273664A1
公开(公告)日：2006-12-07
申请号：US11505910
申请日：2006-08-18
申请人： Christopher Hudson , Thomas Hirt
发明人： Christopher Hudson , Thomas Hirt
IPC分类号： H01H61/06
CPC分类号： H05B41/42 , Y10T307/878 , Y10T307/891
摘要： A protection circuit for an HID dimming circuit is provided. A resistive component limits the initial current after a relay closes and current flows from a charged capacitor to a second capacitor. An inductive component limits the rate of change of current through the circuit. A voltage limited device limits voltage across the contacts of a solid state relay. The circuit is preferably formed in a small module that is adapted to be plugged into an HID lighting device.
摘要翻译： 提供了一种用于HID调光电路的保护电路。 继电器闭合后，电阻元件限制初始电流，电流从充电电容流向第二电容。 电感元件限制通过电路的电流变化率。 电压限制器件限制固态继电器触点两端的电压。 该电路优选地形成在适于插入HID照明装置的小型模块中。
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公开(公告)号：US6039913A
公开(公告)日：2000-03-21
申请号：US141252
申请日：1998-08-27
CPC分类号： A61L27/14 , A61L27/16 , A61L27/18 , B01D67/0006 , B01D71/76 , C08J5/00 , G02B1/043 , A61F2/142 , A61F2/16 , B01D2323/24 , B01D2323/30 , B01D2323/34 , B01D71/40 , B01D71/52 , B01D71/70
摘要： The present invention relates to a process for the manufacture of a molding, which comprises the following steps:a) providing at least one prepolymer comprising one or more crosslinkable groups, wherein the prepolymer is an amphiphilic segmented copolymer comprising at least one hydrophobic segment A and one hydrophilic segment B;b) preparing a mesophase of the prepolymer which is at least partly bicontinuous;c) introducing the mesophase obtained into an ophthalmic mold;d) triggering of the crosslinking; ande) opening the mold such that the molding can be removed. The process of the invention is particularly suited for the manufacture of membranes and ophthalmic moldings such as contact lenses.
摘要翻译： 本发明涉及一种用于制造模制品的方法，其包括以下步骤：a）提供至少一种包含一个或多个可交联基团的预聚物，其中所述预聚物是两亲链段共聚物，其包含至少一个疏水链段A和 一个亲水段B; b）制备至少部分双连续的预聚物的中间相; c）将获得的中间相引入眼科模具; d）触发交联; 以及e）打开模具使得可以去除模制品。 本发明的方法特别适用于制造膜和眼用模制品如隐形眼镜。
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公开(公告)号：US09320686B2
公开(公告)日：2016-04-26
申请号：US14343300
申请日：2012-09-10
申请人： Norbert Moszner , Thomas Hirt , Kai Rist , Ulrich Salz , Christoph Weder , Gina Fiore , Christian Heinzmann , Volker Rheinberger
发明人： Norbert Moszner , Thomas Hirt , Kai Rist , Ulrich Salz , Christoph Weder , Gina Fiore , Christian Heinzmann , Volker Rheinberger
IPC分类号： A61K6/083 , A61C7/00 , A61K6/00 , C07D239/47 , C07F3/06 , C08F122/22
CPC分类号： A61K6/0835 , A61K6/0002 , A61K6/0023 , A61K6/083 , C07D239/47 , C07F3/06 , C08F122/22 , C08L33/00
摘要： The invention relates to a dental restorative material which comprises a thermolabile compound of Formula I: [(Z1)m-Q1-X)]k-T-[Y-Q2-(Z2)n]l Formula I, in which T represents a thermolabile unit which contains at least one thermolabile group based on non-covalent interactions, Z1 and Z2 in each case independently represent a polymerizable group selected from vinyl groups, CH2═CR1—CO—O— and CH2═CR1—CO—NR2— or an adhesive group selected from —Si(OR)3, —COOH, —O—PO(OH)2, —PO(OH)2, —SO2OH and —SH, Q1 in each case independently is missing or represents an (m+1)-valent linear or branched aliphatic C1-C20 radical which can be interrupted by —O—, —S—, —CO—O—, —O—CO—, —CO—NR3—, —NR3—CO—, —O—CO—NR3—, —NR3—CO—O— or —NR3—CO—NR3—, Q2 in each case independently is missing or represents an (n+1)-valent linear or branched aliphatic C1-C20 radical which can be interrupted by —O—, —S—, —CO—O—, —O—CO—, —CO—NR3—, —NR3—CO—, —O—CO—NR3—, —NR3—CO—O— or —NR3—CO—NR3—, X and Y in each case independently are missing or represent —O—, —S—, CO—O—, —O—CO—, —CO—NR3— or —NR3—CO—, R, R1, R2 and R3 in each case independently represent H or a C1-C7 alkyl radical, k and l in each case independently are 0, 1, 2 or 3 and m and n in each case independently are 1, 2 or 3.
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公开(公告)号：US20120121518A1
公开(公告)日：2012-05-17
申请号：US13373499
申请日：2011-11-16
申请人： Zhihua Lu , Thomas Hirt
发明人： Zhihua Lu , Thomas Hirt
CPC分类号： B82Y5/00 , A61K9/5146 , A61K49/1818 , B82Y15/00 , C08G63/664 , C08L71/02 , H01F1/0054 , Y10T428/2982
摘要： Multifunctional nanoparticles for imaging and therapeutic drug delivery made from amphiphilic block copolymers having a hydrophobic block and one or more hydrophilic blocks, and at least one internal and one terminal chelating agent units having a paramagnetic metal ion associated therewith.
摘要翻译： 用于成像和治疗药物递送的多功能纳米颗粒由具有疏水嵌段和一个或多个亲水嵌段的两亲嵌段共聚物制成，以及至少一个具有与其相关的顺磁金属离子的内部和一个末端螯合剂单元。
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公开(公告)号：US20110201761A1
公开(公告)日：2011-08-18
申请号：US13095954
申请日：2011-04-28
IPC分类号： C08G77/458 , C08G77/388
CPC分类号： C08G77/42
摘要： The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical moldings, for example ophthalmic moldings such as in particular contact lenses.
摘要翻译： 本发明涉及新的可交联共聚物，其中变量如权利要求中所定义。 本发明的共聚物特别可用于制造生物医学模制品，例如眼用模制品，例如隐形眼镜。
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公开(公告)号：US07521519B1
公开(公告)日：2009-04-21
申请号：US09525158
申请日：2000-03-14
IPC分类号： C08G77/42
CPC分类号： C08G77/42
摘要： The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical molding, for example ophthalmic moldings such as in particular contact lenses.
摘要翻译： 本发明涉及新的可交联共聚物，其中变量如权利要求中所定义。 本发明的共聚物特别可用于制造生物医学成型，例如眼用模制品，例如隐形眼镜。
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