公开(公告)号：US20080091656A1

公开(公告)日：2008-04-17

申请号：US11858741

申请日：2007-09-20

申请人： ELIZABETH CHARNOCK ,  Curtis Thompson ,  Steven Roberts

发明人： ELIZABETH CHARNOCK ,  Curtis Thompson ,  Steven Roberts

IPC分类号： G06F17/30

CPC分类号： G06F16/358 ,  G06F16/242 ,  Y10S707/99933 ,  Y10S715/963 ,  Y10S715/968

摘要： A method of organizing information is disclosed. The method comprises providing a visualization of actor communications in the context of one or more discussion, a discussion including at least one actor and at least one documented communication.

摘要翻译： 公开了组织信息的方法。 该方法包括在一个或多个讨论的上下文中提供演员通信的可视化，包括至少一个演员的讨论和至少一个记录的通信。

公开(公告)号：US09878046B2

公开(公告)日：2018-01-30

申请号：US13135817

申请日：2011-07-15

申请人： Harold Michael Shepard ,  Curtis Thompson ,  Xiaoming Li ,  Gregory I. Frost

发明人： Harold Michael Shepard ,  Curtis Thompson ,  Xiaoming Li ,  Gregory I. Frost

IPC分类号： A61K31/573 ,  A61K47/48 ,  A61K31/37 ,  A61K31/42 ,  A61K38/47 ,  A61K9/00 ,  A61K47/60

CPC分类号： A61K47/60 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/37 ,  A61K31/42 ,  A61K31/573 ,  A61K38/47 ,  C12Y302/01035 ,  A61K2300/00

摘要： Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.

公开(公告)号：US08135711B2

公开(公告)日：2012-03-13

申请号：US12422902

申请日：2009-04-13

申请人： Elizabeth Charnock ,  Curtis Thompson ,  Steven Roberts ,  Jonathan D Nystrom ,  Keith Schon ,  Arpit Bothra ,  Joanes C Espanol ,  Roman Brouk

发明人： Elizabeth Charnock ,  Curtis Thompson ,  Steven Roberts ,  Jonathan D Nystrom ,  Keith Schon ,  Arpit Bothra ,  Joanes C Espanol ,  Roman Brouk

IPC分类号： G06F17/30

CPC分类号： G06F17/30722

摘要： A method to enable improved analysis and use of sociological data, the method comprising identifying causal relationships between a plurality of documents, identifying a plurality of characteristics of a communication, including a modality used, actors involved, proximate events of relevance, and enabling a user to query based on available characteristics.

摘要翻译： 一种能够改进社会学数据的分析和使用的方法，所述方法包括识别多个文档之间的因果关系，识别通信的多个特征，包括所使用的模式，所涉及的参与者，相关的近似事件以及使用户 根据可用特征进行查询。

公开(公告)号：US20120020951A1

公开(公告)日：2012-01-26

申请号：US13135817

申请日：2011-07-15

申请人： Harold Michael Shepard ,  Curtis Thompson ,  Xiaoming Li ,  Gregory I. Frost

发明人： Harold Michael Shepard ,  Curtis Thompson ,  Xiaoming Li ,  Gregory I. Frost

IPC分类号： A61K31/573 ,  A61P17/02 ,  A61P19/00 ,  A61P1/00 ,  A61P17/06 ,  C12N11/08 ,  A61K39/395 ,  A61K48/00 ,  A61K38/02 ,  A61K35/76 ,  A61K38/47 ,  A61P35/00 ,  A61P9/10

CPC分类号： A61K47/60 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/37 ,  A61K31/42 ,  A61K31/573 ,  A61K38/47 ,  C12Y302/01035 ,  A61K2300/00

摘要： Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.

摘要翻译： 本文提供了用于改善全身给药PEG透明质酸降解酶对受试者的不利影响的方法。 所述方法包括全身施用聚乙二醇化透明质酸降解酶，特别是聚乙二醇化透明质酸酶，例如任何动物或细菌透明质酸酶，并给予足以改善不利作用的量的皮质类固醇。 还提供了治疗单药治疗或联合治疗的透明质酸相关疾病或病症的方法。

公开(公告)号：US07421660B2

公开(公告)日：2008-09-02

申请号：US10358786

申请日：2003-02-04

申请人： Elizabeth Charnock ,  Curtis Thompson ,  Steven L Roberts

发明人： Elizabeth Charnock ,  Curtis Thompson ,  Steven L Roberts

IPC分类号： G06F3/00 ,  G06F9/00 ,  G06F17/00

CPC分类号： G06F17/30713 ,  G06F17/30389 ,  Y10S707/99933 ,  Y10S715/963 ,  Y10S715/968

摘要： A method of organizing information is disclosed. The method comprises providing a visualization of actor communications in the context of one or more discussion, a discussion including at least one actor and at least one documented communication.

摘要翻译： 公开了组织信息的方法。 该方法包括在一个或多个讨论的上下文中提供演员通信的可视化，包括至少一个演员的讨论和至少一个记录的通信。

公开(公告)号：US20060271526A1

公开(公告)日：2006-11-30

申请号：US11497199

申请日：2006-07-31

申请人： Elizabeth Charnock ,  Curtis Thompson ,  Steven Roberts ,  Jonathan Nystrom ,  Keith Schon ,  Arpit Bothra ,  Joanes Espanol ,  Roman Brouk

发明人： Elizabeth Charnock ,  Curtis Thompson ,  Steven Roberts ,  Jonathan Nystrom ,  Keith Schon ,  Arpit Bothra ,  Joanes Espanol ,  Roman Brouk

IPC分类号： G06F17/30

CPC分类号： G06Q30/02 ,  Y10S707/99935

摘要： A method to enable improved analysis and use of sociological data, the method comprising identifying causal relationships between a plurality of documents, identifying a plurality of characteristics of a communication, including a modality used, actors involved, proximate events of relevance, and enabling a user to query based on all of the characteristics available.

公开(公告)号：US6065880A

公开(公告)日：2000-05-23

申请号：US36851

申请日：1998-03-09

申请人： Curtis Thompson

发明人： Curtis Thompson

IPC分类号： G06F1/16 ,  G06F13/00

CPC分类号： G06F1/1684 ,  G06F1/1626 ,  G06F1/1632

摘要： An adapter having an L-shaped housing is configured for removable attachment to a conventional PDA. The adapter is electrically coupled with the PDA and includes a laser or other light source configured to selectively emanate a light beam that can be modified into a digital signal. The digital signal can be received by a photo detector on a computer for facilitating a download of data from the PDA to the computer. The light beam from the laser can also be used as a presentation pointer. The adapter further includes a photo detector which is selectively positioned relative to the laser so that the light beam from the laser can be reflected off a bar code and received by the photo detector. The reflected signal is then converted to a digital signal which is then forwarded to the PDA for storage or access of other corresponding information.

摘要翻译： 具有L形壳体的适配器被配置为可移除地附接到常规PDA。 适配器与PDA电耦合并且包括被配置为选择性地发射可以被修改为数字信号的光束的激光器或其他光源。 数字信号可以由计算机上的光电检测器接收，以便于将数据从PDA下载到计算机。 来自激光的光束也可以用作呈现指针。 适配器还包括相对于激光器选择性地定位的光电检测器，使得来自激光器的光束可以被反射离开条形码并由光电检测器接收。 然后将反射信号转换成数字信号，然后将其转发到PDA以存储或访问其他相应的信息。

公开(公告)号：US09333244B2

公开(公告)日：2016-05-10

申请号：US13815311

申请日：2013-02-19

申请人： Xiaoming Li ,  Mysore Ramprasad ,  Curtis Thompson ,  Harold Michael Shepard ,  Louis Howard Bookbinder ,  Gregory Ian Frost

发明人： Xiaoming Li ,  Mysore Ramprasad ,  Curtis Thompson ,  Harold Michael Shepard ,  Louis Howard Bookbinder ,  Gregory Ian Frost

IPC分类号： A61K38/00 ,  A61K38/47 ,  A61K9/00 ,  A61K9/127

CPC分类号： A61K38/47 ,  A61K9/0034 ,  A61K9/127

摘要： Provided are compositions and formulations or co-formulations containing a hyaluronan degrading enzyme. The compositions, formulations or co-formulations can also contain another therapeutic agent, such as one that is suitable for treatment of Benign Prostatic Hyperplasia, for example, a 5-alpha reductase inhibitor. The compositions and formulations can be used for the treatment of Benign Prostatic Hyperplasia. The compositions and formulations can be provided in combinations with one or more other agents for the treatment of Benign Prostatic Hyperplasia.

公开(公告)号：US20130251786A1

公开(公告)日：2013-09-26

申请号：US13815311

申请日：2013-02-19

申请人： Xiaoming Li ,  Mysore Ramprasad ,  Curtis Thompson ,  Harold Michael Shepard ,  Louis Howard Bookbinder ,  Gregory Ian Frost

发明人： Xiaoming Li ,  Mysore Ramprasad ,  Curtis Thompson ,  Harold Michael Shepard ,  Louis Howard Bookbinder ,  Gregory Ian Frost

IPC分类号： A61K38/47

CPC分类号： A61K38/47 ,  A61K9/0034 ,  A61K9/127

摘要： Provided are compositions and formulations or co-formulations containing a hyaluronan degrading enzyme. The compositions, formulations or co-formulations can also contain another therapeutic agent, such as one that is suitable for treatment of Benign Prostatic Hyperplasia, for example, a 5-alpha reductase inhibitor. The compositions and formulations can be used for the treatment of Benign Prostatic Hyperplasia. The compositions and formulations can be provided in combinations with one or more other agents for the treatment of Benign Prostatic Hyperplasia.

摘要翻译： 提供含有透明质酸降解酶的组合物和制剂或共同制剂。 组合物，制剂或配制剂还可以含有另一种治疗剂，例如适用于治疗良性前列腺增生的治疗剂，例如5-α还原酶抑制剂。 组合物和制剂可用于治疗良性前列腺增生。 组合物和制剂可以与一种或多种其它药物组合提供，用于治疗良性前列腺增生。

公开(公告)号：US20090287685A1

公开(公告)日：2009-11-19

申请号：US12422902

申请日：2009-04-13

申请人： Elizabeth Charnock ,  Curtis Thompson ,  Steven L. Roberts ,  Jonathan D. Nystrom ,  Keith Schon ,  Arpit Bothra ,  Joanes C. Espanol ,  Roman Brouk

发明人： Elizabeth Charnock ,  Curtis Thompson ,  Steven L. Roberts ,  Jonathan D. Nystrom ,  Keith Schon ,  Arpit Bothra ,  Joanes C. Espanol ,  Roman Brouk

IPC分类号： G06F17/30

CPC分类号： G06F17/30722

摘要： A method to enable improved analysis and use of sociological data, the method comprising identifying causal relationships between a plurality of documents, identifying a plurality of characteristics of a communication, including a modality used, actors involved, proximate events of relevance, and enabling a user to query based on available characteristics.

摘要翻译： 一种能够改进社会学数据的分析和使用的方法，所述方法包括识别多个文档之间的因果关系，识别通信的多个特征，包括所使用的模式，所涉及的参与者，相关的近似事件以及使用户 根据可用特征进行查询。