公开(公告)号：US20090155815A1

公开(公告)日：2009-06-18

申请号：US12258037

申请日：2008-10-24

申请人： Bruce L. Grasberger ,  Cynthia Milligan ,  John C. Spurlino ,  Ruth A. Steele ,  Kenneth R. Singleton ,  Alan C. Gibbs ,  Francis A. Lewandowski

发明人： Bruce L. Grasberger ,  Cynthia Milligan ,  John C. Spurlino ,  Ruth A. Steele ,  Kenneth R. Singleton ,  Alan C. Gibbs ,  Francis A. Lewandowski

IPC分类号： G01N33/566 ,  C12N11/02

CPC分类号： C12N9/93 ,  C07K2299/00 ,  C30B29/58 ,  G16B15/00

摘要： A crystallized human ACC2 CT protein as well as a description of the X-ray diffraction pattern of the crystal are disclosed. The diffraction pattern allows the three dimensional structure of human ACC2 CT to be determined at atomic resolution so that ligand binding sites on human ACC2 CT can be identified and the interactions of ligands with human ACC2 CT amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of human ACC2 and human ACC1 proteins.

摘要翻译： 公开了结晶的人ACC2 CT蛋白以及晶体的X射线衍射图的描述。 衍射图允许以原子分辨率确定人ACC2 CT的三维结构，从而可以鉴定人ACC2 CT上的配体结合位点，并且可以建模与配体与人ACC2 CT氨基酸残基的相互作用。 使用这种图谱制备的模型允许设计可用作活性剂的配体，其包括但不限于用作人ACC2和人ACC1蛋白抑制剂的那些。