公开(公告)号：US20230137816A1

公开(公告)日：2023-05-04

申请号：US17904031

申请日：2021-02-10

申请人： DEUTSCHES HERZZENTRUM MUENCHEN DES FREISTAATES BAYERN ,  Klinikum Rechts Der Isar der Technischen Universitaet Muenchen

发明人： Heribert Schunkert ,  Adnan Kastrati ,  Thorsten Kessler

IPC分类号： A61K31/451 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/499 ,  A61K31/4995 ,  A61K31/5386 ,  A61K31/46 ,  A61P9/00 ,  A61K31/27 ,  A61K31/4725 ,  A61K31/454 ,  A61L31/10 ,  A61L29/08 ,  A61L31/16 ,  A61L29/16

摘要： The present invention relates to a medical device suitable for being inserted into the lumen of an anatomic structure of a subject, said medical device comprising means for administration of TRPC6 inhibitor, wherein said means comprises the TRPC6 inhibitor. The present invention further concerns a method of manufacturing a medical device suitable for being inserted into the lumen of an anatomic structure of a subject. Also, the invention relates to a TRPC6 inhibitor for use in the treatment or prevention of a disease associated with neointimal hyperplasia associated with the migration of smooth muscular cells. The invention also relates to a method of treating or preventing a disease associated with neointimal hyperplasia, said method comprising administering a TRPC6 inhibitor to a subject in need thereof. Also envisaged is a method of inhibiting migration of smooth muscle cells. The invention additionally relates to an in vitro test kit comprising: (a) small muscle cells (SMCs); (b) a surface suitable for SMC cultivation coated with a TRPC6 inhibitor. Also concerned is a pharmaceutical composition comprising a TRPC6 inhibitor and a pharmaceutically acceptable carrier.