公开(公告)号：US07745578B2

公开(公告)日：2010-06-29

申请号：US10563726

申请日：2004-07-07

申请人： Mark C. Poznansky ,  Dahlia Doughty

发明人： Mark C. Poznansky ,  Dahlia Doughty

IPC分类号： C07K7/00 ,  C07K14/00 ,  A61K38/00

CPC分类号： A61K38/1709 ,  A61K35/26 ,  A61K38/17 ,  A61K47/646 ,  C07K14/47 ,  G01N33/5029 ,  G01N33/505

摘要： This invention relates to compositions and methods that modulate the movement of cells with migratory capacity. More specifically, the invention relates to compositions and methods for promoting migratory movement, fugetaxis, of cells from a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to promote migratory cell movement away from specific sites in a subject. Specific sites include sites of inflammation, infection, an autoimmune reaction, a tumor and a transplanted organ or tissue.

摘要翻译： 本发明涉及调节具有迁移能力的细胞运动的组合物和方法。 更具体地，本发明涉及用于促进来自受试者中特定部位的细胞的迁移运动，fugetaxis的组合物和方法。 前述内容尤其适用于治疗特征在于需要促进迁移性细胞移动远离受试者的特定部位的病症。 特定部位包括炎症，感染，自身免疫反应，肿瘤和移植的器官或组织的部位。

公开(公告)号：US20060276389A1

公开(公告)日：2006-12-07

申请号：US10563726

申请日：2004-07-07

申请人： Mark Poznansky ,  Dahlia Doughty

发明人： Mark Poznansky ,  Dahlia Doughty

IPC分类号： A61K38/17

CPC分类号： A61K38/1709 ,  A61K35/26 ,  A61K38/17 ,  A61K47/646 ,  C07K14/47 ,  G01N33/5029 ,  G01N33/505

摘要： This invention relates to compositions and methods that modulate the movement of cells with migratory capacity. More specifically, the invention relates to compositions and methods for promoting migratory movement, fugetaxis, of cells from a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to promote migratory cell movement away from specific sites in a subject. Specific sites include sites of inflammation, infection, an autoimmune reaction, a tumor and a transplanted organ or tissue.

摘要翻译： 本发明涉及调节具有迁移能力的细胞运动的组合物和方法。 更具体地，本发明涉及用于促进来自受试者中特定部位的细胞的迁移运动，fugetaxis的组合物和方法。 前述内容尤其适用于治疗特征在于需要促进迁移性细胞移动远离受试者的特定部位的病症。 特定部位包括炎症，感染，自身免疫反应，肿瘤和移植的器官或组织的部位。