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    FOLDABLE CART WITH DEPLOYABLE WHEELS
    2.
    发明申请
    FOLDABLE CART WITH DEPLOYABLE WHEELS 审中-公开

    公开(公告)号：US20200239054A1

    公开(公告)日：2020-07-30

    申请号：US16250567

    申请日：2019-01-17

    Applicant: Daniel Darvish

    Inventor： Daniel Darvish

    IPC: B62B3/02

    Abstract: A foldable cart includes a handle portion, a foldable frame movably connected to the handle, and one or more wheels for rolling on a surface. In an unfolded (in-use or open) condition, the foldable frame constructs a holding-space defining a receiving cavity therein for carrying items, and the action of unfolding the frame automatically deploys wheels to enable immediate use of the cart by the end-user or customer. In a folded (storage or closed) condition, the carts' frame folds to occupy a smaller space in one or more spatial dimensions, and the automatically deployed wheels turn to occupy smaller total space in one or more spatial dimensions. In the folded condition, the cart is easy to store in a small space (e.g. in a small closet, under a bed, etc.) or transport (e.g. in the trunk of an automobile, vehicle, airplane, train, ship with a courier, etc.).

    METHODS AND COMPOSITIONS FOR INCREASING SIALIC ACID PRODUCTION AND TREATING SIALIC RELATED DISEASE CONDITIONS
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR INCREASING SIALIC ACID PRODUCTION AND TREATING SIALIC RELATED DISEASE CONDITIONS 有权

    公开(公告)号：US20220088223A1

    公开(公告)日：2022-03-24

    申请号：US17547031

    申请日：2021-12-09

    Applicant: Daniel Darvish

    Inventor： Daniel Darvish ,  Yadira Valles-Ayoub

    IPC: A61K48/00 ,  C12N15/52 ,  A61P21/00 ,  C12N15/85 ,  A61K38/52

    Abstract: Disclosed herein are methods of expressing UDP-GlcNAc 2-Epimerase/ManNAc Kinase enzyme (GNE) peptide in a cell of a subject comprising: delivering into the cell of the subject an isolated nucleic acid expression construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3, wherein upon the delivering into the cell of the subject, the nucleic acid expression construct initiates expression of the GNE peptide or a therapeutically active fragment thereof. Also disclosed are methods of producing a GNE peptide in a cell comprising infecting the cell with an isolated nucleic acid construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3.

    METHODS AND COMPOSITIONS FOR INCREASING SIALIC ACID PRODUCTION AND TREATING SIALIC RELATED DISEASE CONDITIONS
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR INCREASING SIALIC ACID PRODUCTION AND TREATING SIALIC RELATED DISEASE CONDITIONS 审中-公开
    增加酸性酸生产和治疗SIICIC相关疾病条件的方法和组合物

    公开(公告)号：US20130030040A1

    公开(公告)日：2013-01-31

    申请号：US13364181

    申请日：2012-02-01

    Applicant: Daniel DARVISH ,  Yadira VALLES-AYOUB

    Inventor： Daniel DARVISH ,  Yadira VALLES-AYOUB

    IPC: A61K48/00 ,  A61M5/31 ,  A61P21/00 ,  C12N15/63 ,  C12N9/90

    Abstract: Disclosed herein are methods of expressing UDP-GlcNAc 2-Epimerase/ManNAc Kinase enzyme (GNE) peptide in a cell of a subject comprising: delivering into the cell of the subject an isolated nucleic acid expression construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3, wherein upon the delivering into the cell of the subject, the nucleic acid expression construct initiates expression of the GNE peptide or a therapeutically active fragment thereof. Also disclosed are methods of producing a GNE peptide in a cell comprising infecting the cell with an isolated nucleic acid construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3.

    Abstract translation: 本文公开了在受试者细胞中表达UDP-GlcNAc 2-差向异构酶/ ManNAc激酶（GNE）肽的方法，包括：将分离的核酸表达构建体递送到受试者的细胞中，所述分离的核酸表达构建体包含可操作地连接到核酸的启动子 编码GNE肽或其治疗活性片段的酸序列，其中所述GNE肽具有SEQ ID NO：3的氨基酸序列，其中在递送到所述受试者的细胞中时，所述核酸表达构建体启动所述GNE的表达 肽或其治疗活性片段。 还公开了在细胞中产生GNE肽的方法，包括用分离的核酸构建体感染细胞，所述分离的核酸构建体包含与编码GNE肽或其治疗活性片段的核酸序列可操作地连接的启动子，其中所述GNE肽具有 SEQ ID NO：3的氨基酸序列。

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