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1.发明授权Substituted cycloalkyl-4-oxonicotinic carboxamides; GABA brain receptor ligands 失效取代的环烷基-4-氧基烟酰甲酰胺; GABA脑受体配体公开(公告)号：US06448259B1
公开(公告)日：2002-09-10
申请号：US09565531
申请日：2000-05-05
IPC分类号： A61K31435
CPC分类号： C07D221/04 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Disclosed are compounds of the Formula: or the pharmaceutically acceptable non-toxic salts thereof wherein: the C ring is a(n) (un)substituted carbocycle; X is hydrogen, hydroxyl or lower alkyl; and W is (un)substituted alkyl, aryl, arylalkyl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
摘要翻译： 公开了式或其药学上可接受的无毒盐的化合物，其中：C环是（n）（un）取代的碳环; X是氢，羟基或低级烷基; 并且W是（未取代的）取代的烷基，芳基，芳烷基或杂芳基，该化合物是用于GABAa脑受体的高选择性激动剂，拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药。 这些化合物可用于诊断和治疗焦虑，睡眠和癫痫发作，用苯二氮卓类药物过量并用于记忆增强。
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2.发明授权Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors 失效芳基稠合氨基烷基 - 咪唑衍生物：GABAa受体的选择性调节剂公开(公告)号：US06627624B1
公开(公告)日：2003-09-30
申请号：US09541797
申请日：2000-03-31
IPC分类号： C07D47104
CPC分类号： C07D401/06 , C07D235/14 , C07D405/06 , C07D405/12 , C07D409/12 , C07D471/04
摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are variables defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, depression, overdose with benzodiazepine drugs, and enhancement of memory and alertness.
摘要翻译： 公开了下式的化合物或其药学上可接受的无毒性盐，其中A，B，C，D，X，R 1，R 2，R 3，R 4，R 5和R 6是本文定义的变量， GABAa脑受体的GABAa脑受体的选择性激动剂，拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药，因此可用于诊断和治疗焦虑症，唐氏综合征，睡眠，认知和发作障碍，抑郁症，过量 与苯二氮类药物，并增强记忆力和警觉性。
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3.发明授权Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors 失效杂芳基稠合氨基烷基 - 咪唑衍生物：GABAa受体的选择性调节剂公开(公告)号：US06380210B1
公开(公告)日：2002-04-30
申请号：US09540454
申请日：2000-03-31
IPC分类号： A61K3150
CPC分类号： C07D401/06 , C07D235/14 , C07D405/06 , C07D405/12 , C07D409/12 , C07D471/04
摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are variables defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, depression, overdose with benzodiazepine drugs, and enhancement of memory and alertness.
摘要翻译： 公开了下式的化合物或其药学上可接受的无毒性盐，其中A，B，C，D，X，R 1，R 2，R 3，R 4，R 5和R 6是本文定义的变量， GABAa脑受体的GABAa脑受体的选择性激动剂，拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药，因此可用于诊断和治疗焦虑症，唐氏综合征，睡眠，认知和发作障碍，抑郁症，过量 与苯二氮类药物，并增强记忆力和警觉性。
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4.发明授权Molecular scale latch and associated clocking scheme to provide gain, memory and I/O isolation 失效分子量子锁存器和相关的时钟方案，以提供增益，存储器和I / O隔离公开(公告)号：US06777982B2
公开(公告)日：2004-08-17
申请号：US10116501
申请日：2002-04-03
IPC分类号： H03K1920
CPC分类号： H03K3/315 , B82Y10/00 , G11C13/0014 , G11C13/025 , G11C2211/5614
摘要： Chemically assembled electronic nanotechnology (CAEN) provides an alternative to using Complementary Metal Oxide Semiconductor (CMOS) for constructing circuits with feature sizes in the tens of nanometers. A molecular latch and a method using the latch that enables it to act as a state holding device, perform voltage restoration, and to provide I/O isolation is disclosed.
摘要翻译： 化学组装的电子纳米技术（CAEN）提供了使用互补金属氧化物半导体（CMOS）构建特征尺寸在几十纳米的电路的替代方案。 公开了一种分子锁存器和使用该锁存器使其能够用作状态保持装置，执行电压恢复并提供I / O隔离的方法。
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5.发明授权Substituted cycloalkyl-4-Oxonicotinic carboxamides; gaba brain receptor ligands 失效取代的环烷基-4-氧基烟酰甲酰胺; gaba脑受体配体公开(公告)号：US06194427B1
公开(公告)日：2001-02-27
申请号：US09259244
申请日：1999-02-26
IPC分类号： A61K31435
CPC分类号： C07D221/04 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Disclosed are compounds of the Formula: or the pharmaceutically acceptable non-toxic salts thereof wherein: the C ring is a(n) (un)substituted carbocycle; X is hydrogen, hydroxyl or lower alkyl; and W is (un)substituted alkyl, aryl, arylalkyl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.
摘要翻译： 公开了式或其药学上可接受的无毒盐的化合物，其中：C环是（n）（un）取代的碳环; X是氢，羟基或低级烷基; 和W是（未）取代的烷基，芳基，芳基烷基或杂芳基，该化合物是用于GABAa脑受体的高选择性激动剂，拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前体药物。 这些化合物可用于诊断和治疗焦虑，睡眠和癫痫发作，用苯二氮卓类药物过量并用于记忆增强。
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6.发明授权公开(公告)号：US07064000B2
公开(公告)日：2006-06-20
申请号：US10889294
申请日：2004-07-12
CPC分类号： H03K3/315 , B82Y10/00 , G11C13/0014 , G11C13/025 , G11C2211/5614
摘要： Chemically assembled electronic nanotechnology (CAEN) provides an alternative to using Complementary Metal Oxide Semiconductor (CMOS) for constructing circuits with feature sizes in the tens of nanometers. A molecular latch and a method using the latch that enables it to act as a state holding device, perform voltage restoration, and to provide I/O isolation is disclosed.
摘要翻译： 化学组装的电子纳米技术（CAEN）提供了使用互补金属氧化物半导体（CMOS）构建特征尺寸在几十纳米的电路的替代方案。 公开了一种分子锁存器和使用该锁存器使其能够用作状态保持装置，执行电压恢复并提供I / O隔离的方法。
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7.发明授权Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors 失效杂芳基稠合氨基烷基 - 咪唑衍生物：GABAa受体的选择性调节剂公开(公告)号：US06972293B2
公开(公告)日：2005-12-06
申请号：US10609941
申请日：2003-06-30
IPC分类号： C07D235/10 , C07D235/14 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D471/04 , A61K31/44 , A61K31/415 , C07D471/02
CPC分类号： C07D401/06 , C07D235/14 , C07D405/06 , C07D405/12 , C07D409/12 , C07D471/04
摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are variables defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, depression, overdose with benzodiazepine drugs, and enhancement of memory and alertness.
摘要翻译： 公开了下式的化合物或其药学上可接受的无毒盐，其中A，B，C，D，X，R 1，R 2， R 3，R 4，R 5和R 6是本文定义的变量，这些化合物是高度选择性的激动剂 ，GABAa脑受体的拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药，因此可用于诊断和治疗焦虑症，唐氏综合征，睡眠，认知和癫痫发作障碍，抑郁症，苯并二氮卓过量 药物，提高记忆力和警觉性。
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