公开(公告)号：US20120269738A1

公开(公告)日：2012-10-25

申请号：US13447127

申请日：2012-04-13

申请人： Wanggui YANG ,  Yi WONG ,  Olivia T. W. NG ,  Hung Wing LI ,  Ken K. L. YUNG ,  Daniel W. J. KWONG ,  Ricky M. S. WONG

发明人： Wanggui YANG ,  Yi WONG ,  Olivia T. W. NG ,  Hung Wing LI ,  Ken K. L. YUNG ,  Daniel W. J. KWONG ,  Ricky M. S. WONG

IPC分类号： A61K49/10 ,  A61K31/4709 ,  G01N21/76 ,  A61P25/28 ,  A61K49/00 ,  A61K31/4439 ,  A61K31/473

CPC分类号： C07D401/06 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/473 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0026 ,  A61K49/085 ,  A61K49/10

摘要： The present invention relates to methods of detecting and monitoring aggregation of beta-amyloid peptides which are associated with neurodegenerative diseases as well as treating and/or preventing the neurodegenerative diseases by using carbazole-based fluorophores. In particular, the present invention provides methods for labeling and imaging the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro and/or in vivo, as well as treating and/or preventing Alzheimer's disease by using the carbazole-based fluorophores of the present invention.

摘要翻译： 本发明涉及检测和监测与神经变性疾病相关的β-淀粉样肽聚集以及通过使用咔唑类荧光团治疗和/或预防神经变性疾病的方法。 特别地，本发明提供了用于在体外和/或体内标记和成像β-淀粉样蛋白（A＆bgr））肽，寡聚体和原纤维的方法，以及通过使用咔唑类治疗和/或预防阿尔茨海默氏病 荧光团。

公开(公告)号：US09156814B2

公开(公告)日：2015-10-13

申请号：US13447127

申请日：2012-04-13

申请人： Wanggui Yang ,  Yi Wong ,  Olivia T. W. Ng ,  Hung Wing Li ,  Ken K. L. Yung ,  Daniel W. J. Kwong ,  Ricky M. S. Wong

发明人： Wanggui Yang ,  Yi Wong ,  Olivia T. W. Ng ,  Hung Wing Li ,  Ken K. L. Yung ,  Daniel W. J. Kwong ,  Ricky M. S. Wong

IPC分类号： A61K49/10 ,  A61K49/00 ,  C07D401/06 ,  A61K49/08 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/473

CPC分类号： C07D401/06 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/473 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0026 ,  A61K49/085 ,  A61K49/10

摘要： The present invention relates to methods of detecting and monitoring aggregation of beta-amyloid peptides which are associated with neurodegenerative diseases as well as treating and/or preventing the neurodegenerative diseases by using carbazole-based fluorophores. In particular, the present invention provides methods for labeling and imaging the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro and/or in vivo, as well as treating and/or preventing Alzheimer's disease by using the carbazole-based fluorophores of the present invention.

摘要翻译： 本发明涉及检测和监测与神经变性疾病相关的β-淀粉样肽聚集以及通过使用咔唑类荧光团治疗和/或预防神经变性疾病的方法。 特别地，本发明提供了用于在体外和/或体内标记和成像β-淀粉样蛋白（A＆bgr））肽，寡聚体和原纤维的方法，以及通过使用咔唑类治疗和/或预防阿尔茨海默氏病 荧光团。