公开(公告)号：US4863898A

公开(公告)日：1989-09-05

申请号：US826786

申请日：1986-02-06

申请人： Harvey H. Ashmead ,  H. Dewayne Ashmead ,  Darrell J. Graff

发明人： Harvey H. Ashmead ,  H. Dewayne Ashmead ,  Darrell J. Graff

IPC分类号： A61K31/28 ,  A61K31/195 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/24 ,  A61K33/26 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K38/00 ,  A61K38/04 ,  A61K47/18 ,  A61K47/22 ,  A61K47/42 ,  A61K47/46 ,  A61P3/00 ,  A61P43/00

CPC分类号： A61K38/04 ,  A61K31/195 ,  Y10S514/88 ,  Y10S514/891 ,  Y10S514/893

摘要： Amino acid chelates having a ligand to divalent metal mole ratio of at least 2:1 and having a molecular weight of not more than 1500 and preferably not more than 1000 and also having a stability constant of between about 10 and 10 are formulated for delivery to one or more specific tissue sites within a mammal. The ligand utilized in formulating the amino acid chelate is a naturally occuring amino acid or a dipeptide, tripeptide or quadrapeptide thereof. The selection of an appropriate ligand with which to form the chelate provides a product that, when entering the bloodstream of the mammal, either by mean of oral ingestion or injection, has a propensity to migrate to one or more targeted tissue sites within the mammal.

摘要翻译： 具有二价金属摩尔比为至少2:1且分子量不超过1500，优选不大于1000，并且具有约10至10的稳定常数的氨基酸螯合物被配制成用于递送至 哺乳动物内的一个或多个特定组织部位。 用于配制氨基酸螯合物的配体是天然存在的氨基酸或其二肽，三肽或四肽。 与其形成螯合物的合适配体的选择提供了当通过口服摄取或注射进入哺乳动物的血液流时具有迁移到哺乳动物内的一个或多个靶组织位点的倾向的产物。