公开(公告)号：US08518391B1

公开(公告)日：2013-08-27

申请号：US12610815

申请日：2009-11-02

申请人： Dave Morgan ,  Siddharth G. Kamath ,  Lori Lebson

发明人： Dave Morgan ,  Siddharth G. Kamath ,  Lori Lebson

IPC分类号： A61K48/00 ,  C12N5/078

CPC分类号： C12N5/0645 ,  A61K48/0075 ,  C07K2319/02 ,  C12N9/6494 ,  C12N2510/00

摘要： Disclosed is a method for the treatment of a neurodegenerative disorder by isolating a plurality of monocytic cells and introducing a vector containing a gene that expresses a protease capable of degrading amyloid peptide into the isolated monocytic cells. The modified cells are then administered to the patient. Preferably the introduced gene is selected from the group consisting of neprilysin, insulin degrading enzyme and endothelin converting enzyme. The protease capable of degrading amyloid peptide is secreted from the monocytic cells into the extracellular space thereof. According to one variant, the gene that expresses a protease capable of degrading amyloid peptide is the NEP gene with a deletion in the membrane binding domain and/or an appended signal peptide to drive secretion of the modified gene product. This invention contemplates the use of heterologous and autologos (the monocytic cells are obtained from the patient) transplants.

摘要翻译： 公开了一种通过分离多个单核细胞并将含有表达能够将淀粉样蛋白肽降解的蛋白酶的基因的载体引入到分离的单核细胞中的方法来治疗神经变性疾病。 然后将修饰的细胞施用于患者。 优选地，引入的基因选自由尿丙氨酸，胰岛素降解酶和内皮素转化酶组成的组。 能够降解淀粉样蛋白肽的蛋白酶从单核细胞分泌到其细胞外空间中。 根据一个变体，表达能够降解淀粉样蛋白肽的蛋白酶的基因是在膜结合域中具有缺失的NEP基因和/或附加的信号肽以驱动修饰的基因产物的分泌。 本发明考虑使用异源和自体（单核细胞获自患者）移植物。

公开(公告)号：US20100269134A1

公开(公告)日：2010-10-21

申请号：US12714937

申请日：2010-03-01

申请人： Jeffrey Storan ,  Patrick Angeles ,  Dave Morgan

发明人： Jeffrey Storan ,  Patrick Angeles ,  Dave Morgan

IPC分类号： H04N7/025

CPC分类号： H04N21/812 ,  G06Q30/02 ,  H04N21/252 ,  H04N21/25833 ,  H04N21/25891 ,  H04N21/26258 ,  H04N21/4532

摘要： A computer implemented method and apparatus for determining an optimal time and channel for delivery of television advertising content based on viewer profile information is disclosed. The method and apparatus provide for collecting viewer profile information for a viewer and storing it in a computer memory. Segments of viewers may be defined by viewer profile information thresholds in the computer memory. Viewers may be assigned to an audience segment based on a comparison of the viewer profile information thresholds with the collected viewer profile information. Information describing programs to be promoted, spots in which promotions for such programs may air, and geographic data also may be collected and stored. The computer may determine an optimal time and channel for delivery of the television advertising content to a selected audience segment based on the program to be promoted information, spot information and geographic data. The method and apparatus may be of particular use in determining optimal channels and times for promotion of a television program on a channel/network other than the channel/network on which the program is to air (i.e., cross-network promotion).

摘要翻译： 公开了一种用于基于观看者简档信息来确定用于传送电视广告内容的最佳时间和频道的计算机实现的方法和装置。 所述方法和装置提供用于收集观看者的观看者简档信息并将其存储在计算机存储器中。 可以通过计算机存储器中的查看器简档信息阈值来定义观看者的细分。 基于观众简档信息阈值与收集的观众简档信息的比较，可以将观众分配给观众段。 描述要推广的节目的信息，可以收集和存储此类节目的促销活动的空间以及地理数据。 计算机可以基于要推广的程序，现场信息和地理数据，确定将电视广告内容传送到所选择的观众段的最佳时间和频道。 该方法和装置可以特别用于确定促进节目空中的频道/网络之外的频道/网络上的电视节目的最佳频道和时间（即跨网络推广）。

公开(公告)号：US08627356B2

公开(公告)日：2014-01-07

申请号：US12714937

申请日：2010-03-01

申请人： Jeffrey Storan ,  Patrick Angeles ,  Dave Morgan

发明人： Jeffrey Storan ,  Patrick Angeles ,  Dave Morgan

IPC分类号： H04N21/258 ,  H04N21/262 ,  H04N21/25

CPC分类号： H04N21/812 ,  G06Q30/02 ,  H04N21/252 ,  H04N21/25833 ,  H04N21/25891 ,  H04N21/26258 ,  H04N21/4532

摘要： A computer implemented method and apparatus for determining an optimal time and channel for delivery of television advertising content based on viewer profile information is disclosed. The method and apparatus provide for collecting viewer profile information for a viewer and storing it in a computer memory. Segments of viewers may be defined by viewer profile information thresholds in the computer memory. Viewers may be assigned to an audience segment based on a comparison of the viewer profile information thresholds with the collected viewer profile information. Information describing programs to be promoted, spots in which promotions for such programs may air, and geographic data also may be collected and stored. The computer may determine an optimal time and channel for delivery of the television advertising content to a selected audience segment based on the program to be promoted information, spot information and geographic data. The method and apparatus may be of particular use in determining optimal channels and times for promotion of a television program on a channel/network other than the channel/network on which the program is to air (i.e., cross-network promotion).

摘要翻译： 公开了一种用于基于观看者简档信息来确定用于传送电视广告内容的最佳时间和频道的计算机实现的方法和装置。 所述方法和装置提供用于收集观看者的观看者简档信息并将其存储在计算机存储器中。 可以通过计算机存储器中的查看器简档信息阈值来定义观看者的细分。 基于观众简档信息阈值与收集的观众简档信息的比较，可以将观众分配给观众段。 描述要推广的节目的信息，可以收集和存储此类节目的促销活动的空间以及地理数据。 计算机可以基于要推广的程序，现场信息和地理数据，确定将电视广告内容传送到所选择的观众段的最佳时间和频道。 该方法和装置可以特别用于确定促进节目空中的频道/网络之外的频道/网络上的电视节目的最佳频道和时间（即跨网络推广）。