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    HETEROCYCLIC COMPOUNDS AS INHIBITORS OF BETA-LACTAMASES
    2.
    发明申请
    HETEROCYCLIC COMPOUNDS AS INHIBITORS OF BETA-LACTAMASES 审中-公开
    作为β-Lactamases的抑制剂的杂环化合物

    公开(公告)号：US20100048528A1

    公开(公告)日：2010-02-25

    申请号：US12610562

    申请日：2009-11-02

    申请人： Jozsef Aszodi ,  Claude Fromentin ,  Maxime Lampilas ,  David Alan Rowlands

    发明人： Jozsef Aszodi ,  Claude Fromentin ,  Maxime Lampilas ,  David Alan Rowlands

    IPC分类号： A61K31/546 ,  A61K31/439 ,  A61K31/431

    CPC分类号： A61K31/439 ,  A61K31/55 ,  A61K2300/00

    摘要： This invention discloses and claims methods for inhibiting bacterial β-lactamases and treating bacterial infections by inhibiting bacterial β-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a β-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a β-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.

    摘要翻译： 本发明公开并要求了通过抑制人或动物中的细菌和β-内酰胺酶来抑制细菌和β-内酰胺酶和治疗细菌感染的方法，包括向所述人或所述动物施用治疗有效量的化合物或其药学上可接受的盐 ，式（I）单独或与β-乳糖抗生素组合，其中所述组合可以分开施用，一起或随时间隔开。 还公开并要求保护包含式（I）化合物或式（I）化合物与治疗有效量的β-乳糖抗生素和药学上可接受的载体的组合物的药物组合物。

    Heterocyclic compounds as inhibitors of beta-lactamases
    5.
    发明授权
    Heterocyclic compounds as inhibitors of beta-lactamases 有权
    杂环化合物作为β-内酰胺酶的抑制剂

    公开(公告)号：US07612087B2

    公开(公告)日：2009-11-03

    申请号：US10898754

    申请日：2004-07-26

    申请人： Jozsef Aszodi ,  Claude Fromentin ,  Maxime Lampilas ,  David Alan Rowlands

    发明人： Jozsef Aszodi ,  Claude Fromentin ,  Maxime Lampilas ,  David Alan Rowlands

    IPC分类号： A61K31/44 ,  A61K31/545

    CPC分类号： A61K31/439 ,  A61K31/55 ,  A61K2300/00

    摘要： This invention discloses and claims methods for inhibiting bacterial β-lactamases and treating bacterial infections by inhibiting bacterial β-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a β-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a β-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.

    摘要翻译： 本发明公开并要求通过抑制人或动物中的细菌β-内酰胺酶抑制细菌β-内酰胺酶和治疗细菌感染的方法，包括向所述人或所述动物施用治疗有效量的化合物或其药学上可接受的盐 式（I）单独或与β-内酰胺抗生素组合，其中所述组合可以分开施用，一起或随时间隔开。 还公开和要求保护包含式（I）化合物或式（I）化合物与治疗有效量的β-内酰胺抗生素和药学上可接受的载体的组合物的药物组合物。

    HETEROCYCLIC COMPOUNDS AS INHIBITORS OF BETA-LACTAMASES
    6.
    发明申请
    HETEROCYCLIC COMPOUNDS AS INHIBITORS OF BETA-LACTAMASES 审中-公开
    作为β-Lactamases的抑制剂的杂环化合物

    公开(公告)号：US20090215747A1

    公开(公告)日：2009-08-27

    申请号：US12434270

    申请日：2009-05-01

    申请人： Jozsef Aszodi ,  Claude Fromentin ,  Maxime Lampilas ,  David Alan Rowlands

    发明人： Jozsef Aszodi ,  Claude Fromentin ,  Maxime Lampilas ,  David Alan Rowlands

    IPC分类号： A61K31/55

    CPC分类号： A61K31/439 ,  A61K31/55 ,  A61K2300/00

    摘要： This invention discloses and claims methods for inhibiting bacterial β-lactamases and treating bacterial infections by inhibiting bacterial β-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a β-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a β-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.

    摘要翻译： 本发明公开并要求通过抑制人或动物中的细菌β-内酰胺酶抑制细菌β-内酰胺酶和治疗细菌感染的方法，包括向所述人或所述动物施用治疗有效量的化合物或其药学上可接受的盐 式（I）单独或与β-内酰胺抗生素组合，其中所述组合可以分开施用，一起或随时间隔开。 还公开和要求保护包含式（I）化合物或式（I）化合物与治疗有效量的β-内酰胺抗生素和药学上可接受的载体的组合物的药物组合物。

    HETEROCYCLIC COMPOUNDS AS INHIBITORS OF BETA-LACTAMASES
    9.
    发明申请
    HETEROCYCLIC COMPOUNDS AS INHIBITORS OF BETA-LACTAMASES 审中-公开
    作为β-Lactamases的抑制剂的杂环化合物

    公开(公告)号：US20110245254A1

    公开(公告)日：2011-10-06

    申请号：US13161783

    申请日：2011-06-16

    申请人： Jozsef Aszodi ,  Claude Fromentin ,  Maxime Lampilas ,  David Alan Rowlands

    发明人： Jozsef Aszodi ,  Claude Fromentin ,  Maxime Lampilas ,  David Alan Rowlands

    IPC分类号： A61K31/504 ,  A61K31/46 ,  A61P31/04

    CPC分类号： A61K31/439 ,  A61K31/55 ,  A61K2300/00

    摘要： This invention discloses and claims methods for inhibiting bacterial β-lactamases and treating bacterial infections by inhibiting bacterial β-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a β-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a β-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.

    摘要翻译： 本发明公开并要求了通过抑制人或动物中的细菌和β-内酰胺酶来抑制细菌和β-内酰胺酶和治疗细菌感染的方法，包括向所述人或所述动物施用治疗有效量的化合物或其药学上可接受的盐 ，式（I）单独或与β-乳糖抗生素组合，其中所述组合可以分开施用，一起或随时间隔开。 还公开并要求保护包含式（I）化合物或式（I）化合物与治疗有效量的β-乳糖抗生素和药学上可接受的载体的组合物的药物组合物。