公开(公告)号：US20070071755A1

公开(公告)日：2007-03-29

申请号：US11235337

申请日：2005-09-27

申请人： David Balasundaram ,  Du Xianming ,  Sundarasamy Mahalingam

发明人： David Balasundaram ,  Du Xianming ,  Sundarasamy Mahalingam

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  C12N9/16 ,  C07H21/04 ,  C12P21/06

CPC分类号： C12N9/16

摘要： There is provided an isolated polypeptide comprising an amino acid sequence at least 85% homologous to SEQ ID NO: 2 or SEQ ID N: 4, or a conservative variant thereof, wherein the polypeptide regulates proliferation of a cell. There is also provided an isolated polynucleotide encoding the polypeptide of the invention. There is also provided a method for inhibiting the proliferation of a cell, comprising altering the level of a polypeptide comprising an amino acid sequence at least 85% homologous to SEQ ID NO: 2 or SEQ ID NO: 4 in the cell, thereby inhibiting proliferation of the cell.

摘要翻译： 提供了分离的多肽，其包含与SEQ ID NO：2或SEQ ID NO：4或其保守变体至少85％同源的氨基酸序列，其中所述多肽调节细胞的增殖。 还提供了编码本发明多肽的分离的多核苷酸。 还提供了抑制细胞增殖的方法，包括改变包含与细胞中SEQ ID NO：2或SEQ ID NO：4至少85％同源的氨基酸序列的多肽的水平，由此抑制增殖 的细胞。